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Health Initiatives in Psoriasis and PsOriatic arthritis ConsoRTium European States

Deliverables

Harmonised WP3 dataset available
Clinical characteristics associated with structural and functional progression
HPOS: First study subject approvals package

HPOS Prior to enrolment of first study subject i Final version of study protocol as submitted toregulatorsethics committees ii Registration number of clinical study in a WHOor ICMJE approvedregistry with the possibility to post results iii Approvals ethics committees and national competentauthority if applicable required for invitationenrolment of first subject in at least one clinical centre

Establishing HPOS

Publications

Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomography

Author(s): Tascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.
Published in: Rheumatology (oxford), 2023, ISSN 1462-0332
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac346

DeepNAPSI multi-reader nail psoriasis prediction using deep learning

Author(s): Lukas Folle, Pauline Fenzl, Filippo Fagni , Mareike Thies, Vincent Christlein, Christine Meder , David Simon , Ioanna Minnopoulou , Michael Sticherling , Georg Schett , Andreas Maier, Arnd Kleyer
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-32440-8

"Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns-How Neural Networks Can Tell Us Where to ""Deep Dive"" Clinically."

Author(s): Lukas Folle; David Simon; Koray Tascilar; Gerhard Krönke; Anna-Maria Liphardt; Andreas Maier; Georg Schett; Arnd Kleyer
Published in: Frontiers in Medicine, Issue 3, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.3389/fmed.2022.850552

Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projects

Author(s): S. Rischke, L. Hahnefeld, B. Burla, F. Behrens, R. Gurke, T.J. Garrett
Published in: Journal of Mass Spectrometry and Advances in the Clinical Lab, Issue Volume 28, April 2023, 2023, Page(s) 47-55, ISSN 2667-145X
Publisher: Elevier B.V.
DOI: 10.1016/j.jmsacl.2023.02.003

Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical research

Author(s): A. Sens, S. Rischke, L. Hahnefeld, E. Dorochow, S.M.G. Schäfer, D. Thomas, M. Köhm, G. Geisslinger, F. Behrens, R. Gurke,
Published in: Journal of Mass Spectrometry and Advances in the Clinical Lab, Issue Volume 28, April 2023, 2023, Page(s) 35-46, ISSN 2667-145X
Publisher: Elsevier B.V.
DOI: 10.1016/j.jmsacl.2023.02.002

OMICS and multi‐OMICS analysis for the early identification and improved outcome of patients with psoriatic arthritis

Author(s): """Robert Gurke 1,2,3,*, Annika Bendes 4, John Bowes 5,6, Michaela Koehm 1,2,7, Richard M Twyman 8, Anne Barton 5,6, 4 Carl Goodyear 9, Lisa Hahnefeld 1,2,3, Rainer Hillenbrand 10, Ewan Hunter 11, Mark Ibberson 12, Vassilios Ioannidis 12, 5 Sabine Kugler 2,13, Eduard Resch 1,2, Stefan Rüping 2,13, Klaus Scholich 1,2,3, Jochen M Schwenk 4, James C 6 Waddington 14, Phil Whitfield 15, Gerd Geißlinger"
Published in: Biomedicines, 2023, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10102387

Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritis

Author(s): David Simon, Filippo Fagni, Georg Schett
Published in: Annals of the Rheumatic Diseases, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2022-222415

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis

Author(s): Giulia Corte, Sara Bayat, Koray Tascilar, Larissa Valor-Mendez, Louis Schuster, Johannes Knitza, Filippo Fagni, Georg Schett, Arnd Kleyer and David Simon
Published in: Diagnostics, 2021, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics11071139

Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritis

Author(s): David Simon, Filippo Fagni, Georg Schett
Published in: Ann Rheum Dis, 2022, ISSN 1468-2060
Publisher: BMJ Publishing group
DOI: 10.1136/annrheumdis-2022-222415

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

Author(s): Folle L, Bayat S, Kleyer A, Fagni F, Kapsner LA, Schlereth M, Meinderink T, Breininger K, Tacilar K, Krönke G, Uder M, Sticherling M, Bickelhaupt S, Schett G, Maier A, Roemer F, Simon D.
Published in: Rheumatology, 2022, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keac197

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses

Author(s): Fagni F, Simon D, Tascilar K, Schoenau V, Sticherling M, Neurath MF, Schett G.
Published in: Lancet Rheum, 2021, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(21)00247-2

Applying precision medicine to unmet clinical needs in psoriatic disease

Author(s): Deepak R. Jadon; Carmel B. Stober; Stephen R. Pennington; Oliver FitzGerald
Published in: Applying precision medicine to unmet clinical needs in psoriatic disease, Issue 2, 2021, ISSN 1759-4804
Publisher: Nature Portfolio
DOI: 10.17863/cam.58303

"Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns-How Neural Networks Can Tell Us Where to ""Deep Dive"" Clinically"

Author(s): Folle L, Simon D, Tascilar K, Krönke G, Liphardt AM, Maier A, Schett G, Kleyer A.
Published in: Frontiers in Medicine, 2022, ISSN 2296-858X
Publisher: frontiers
DOI: 10.3389/fmed.2022.850552

Applying precision medicine to unmet clinical needs in psoriatic disease

Author(s): Deepak R. Jadon, Carmel Stober, Stephen R. Pennington and Oliver FitzGerald
Published in: Applying precision medicine to unmet clinical needs in psoriatic disease, 2021, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00507-9

Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients

Author(s): Pachowsky ML, Raimondo MG, Xu C, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A.
Published in: Ann Rheum Dis, 2021, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222061

HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis.

Author(s): FitzGerald, O., Pennington, S.R.
Published in: HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis, Issue 17594804, 2022, ISSN 1759-4804
Publisher: Nat Rev Rheumatol
DOI: 10.1038/s41584-022-00748-w

Humoral and Cellular Immune Responses to SARS?CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell Depletion

Author(s): Simon, D., Tascilar, K., Schmidt, K., Manger, B., Weckwerth, L., Sokolova, M., Bucci, L., Fagni, F., Manger, K., Schuch, F., Ronneberger, M., Hueber, A., Steffen, U., Mielenz, D., Herrmann, M., Harrer, T., Kleyer, A., Krönke, G. and Schett, G.
Published in: Arthritis Rheum, 2022, ISSN 2326-5205
Publisher: John Wiley & Sons (Wiley)
DOI: 10.1002/art.41914

Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritis

Author(s): Lukas Folle; Sara Bayat; Arnd Kleyer; Filippo Fagni; Lorenz A Kapsner; Maja Schlereth; Timo Meinderink; Katharina Breininger; Koray Tascilar; Gerhard Krönke; Michael Uder; Michael Sticherling; Sebastian Bickelhaupt; Georg Schett; Andreas Maier; Frank Roemer; David Simon
Published in: Rheumatology, Issue 4, 2022, ISSN 1462-0332
Publisher: BMJ Publishing group
DOI: 10.1093/rheumatology/keac197

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis

Author(s): Giulia Corte, Sara Bayat, Koray Tascilar, Larissa Valor-Mendez, Louis Schuster, Johannes Knitza, Filippo Fagni, Georg Schett, Arnd Kleyer and David Simon
Published in: Diagnostics, 2022, ISSN 2075-4418
Publisher: MDPI 
DOI: 10.3390/diagnostics11071139

Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS?CoV-2 in an Unvaccinated Cohort

Author(s): David Simon, Koray Tascilar, Arnd Kleyer, Filippo Fagni, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Thorsten Kliem, Johanna Mößner, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J. Hueber, Karin Manger, Bernhard Manger, Raja Atr
Published in: Arthritis & Rheumatology, 2022, ISSN 2326-5205
Publisher: John Wiley & Sons (Wiley)
DOI: 10.1002/art.42035

Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 Infection

Author(s): Schmidt KG, Harrer EG, Tascilar K, Kübel S, El Kenz B, Hartmann F, Simon D, Schett G, Nganou-Makamdop K, Harrer T.
Published in: Viruses, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14030651

Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patients

Author(s): Pachowsky ML, Raimondo MG, Xu C, Rauber S, Tascilar K, Labinsky H, Vogg M, Aziz Saad MS, Simon D, Rech J, Soare A, Braeuer L, Kleyer A, Schett G, Ramming A.
Published in: Annals of the Rheumatic Diseases, 2022, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-222061

Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccination

Author(s): Filippo Fagni, Katja Schmidt, Daniela Bohr, Larissa Valor-Méndez, Fabian Hartmann, Koray Tascilar, Karin Manger, Bernhard Manger, Arnd Kleyer, David Simon, Georg Schett and Thomas Harrer
Published in: RMD Open, 2022, ISSN 2056-5933
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2022-002323

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