Project description
New clinical trial design for tuberculosis drugs
As with many bacterial diseases, tuberculosis has been hit by drug resistance, threatening the efficacy of existing treatments. Although there are new drugs for clinical evaluation, testing the different combinations is time-consuming and requires a concerted effort. The EU-funded UNITE4TB project brings together experts in the field to design and set new standards for tuberculosis Phase II clinical trials. The team will take advantage of existing networks across continents to recruit patients in trials and introduce state-of-the-art microbiology methods and machine learning technologies. Data on biomarkers and clinical pharmacology will accompany the validation of the new drugs to ensure their subsequent success down the drug discovery pipeline.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance
- medical and health sciencesclinical medicinepneumologytuberculosis
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- natural sciencesbiological sciencesmicrobiology
- natural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software
Programme(s)
Topic(s)
Funding Scheme
IMI2-RIA - Research and Innovation actionCoordinator
6525 GA Nijmegen
Netherlands
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Participants (31)
WC1E 7HT London
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OX1 2JD Oxford
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23845 Borstel
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3521 AL Utrecht
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
LA1 4YW Lancaster
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WC1E 6BT London
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7530 Cape Town
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20132 Milano
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85764 Neuherberg
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2516 AB 'S Gravenhage
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2 Dublin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
S10 2PX Sheffield
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
1040 Brussels
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4050 290 Porto
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
L69 7ZX Liverpool
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13572 Marseille
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20148 Hamburg
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94607 Oakland Ca
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10005 New York
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1202 Geneve
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20122 Milano
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KY16 9AJ St Andrews
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751 05 Uppsala
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1003 Lausanne
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23843 Bad Oldesloe
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28760 Tres Cantos Madrid
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2340 Beerse
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80636 Munchen
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38124 Braunschweig
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80539 Muenchen
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
81377 Munchen
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