Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease

Project Information

CRYSTAL3

Grant agreement ID: 101007931

DOI 10.3030/101007931

EC signature date 2 October 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 887 800,00

EU contribution € 887 800,00

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Deliverables

Other (1)

CRYSTAL3 initiation

Initiation of CRYSTAL3: Kick-off Meeting and Initiation of Secondments

Documents, reports (1)

CRYSTAL3 portfolio Part1

Part1 of A portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

Websites, patent fillings, videos etc. (1)

CRYSTAL3 Website and Scocial Media

Launch of CRYSTAL3 social mediawebsite

Publications

Peer reviewed articles (14)

Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer

Author(s): Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren and Lasse D. Jensen
Published in: Journal of Experimental & Clinical Cancer Research, Issue 41, Article number: 58, 2022, ISSN 0392-9078
Publisher: BioMed Central
DOI: 10.1186/s13046-022-02280-x

1,4-dihydroxy quininib activates ferroptosis pathways inmetastatic uveal melanoma and reveals a novel prognosticbiomarker signature

Author(s): Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly1, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon4, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey and Breandán N. Kennedy.
Published in: Cell Death Discovery, 2024, ISSN 2058-7716
Publisher: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Discovery and Development of the Quininib Series of Ocular Drugs

Author(s): Niamh Mahon, Kayleigh Slater, Justine O'Brien, Yolanda Alvarez, Alison Reynolds, and Breandán Kennedy
Published in: Journal of Ocular Pharmacology and Therapeutics, Issue 38, 1, 2022, ISSN 1080-7683
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/jop.2021.0074

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Author(s): Husvinee Sundaramurthi, Zoltán Giricz, and Breandán N. Kennedy
Published in: International Journal of Molecular Sciences, Issue Volume 13, Issue 16, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169378

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Author(s): Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Published in: Open Research Europe, Issue 1, 2021, Page(s) 92, ISSN 2732-5121
Publisher: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Author(s): Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O'Connell, Eve O’Reilly, Marcel Costa-Garcia, Csenger Kovácsházi, Agnes Kittel, Simone Marcone, Alfonso Blanco, Eva Pallinger, Szabolcs Hambalkó, Jose Maria Piulats Rodriguez, Péter Ferdinandy , Jacintha O'Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, and Breandán N. Kennedy
Published in: Open Research Europe, 2023, ISSN 2732-5121
Publisher: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15973.1

An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue

Author(s): Federico Bleckwedel, Giulia Germena, Laura C. Zelarayán
Published in: Trillium Extracellular Vesicles, 2022, ISSN 2698-8739
Publisher: Trillium-Verlag
DOI: 10.47184/tev.2022.01.03

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Author(s): Alicia Gómez Sánchez, Patrizia Colucci, Ailis Moran, Alexandro Moya López, Basilio Colligris, Yolanda Álvarez and Breandán N. Kennedy
Published in: Open Research Europe, 2023, ISSN 2732-5121
Publisher: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15491.1

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Author(s): Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D Jensen
Published in: Cells, Issue 2023 Feb 3;12(3):508, 2023, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells12030508

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Author(s): Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Published in: Cancers, Issue 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Author(s): Ailís L. Moran; Stephen P. Carter; Joanna J. Kaylor; Zhichun Jiang; Sanne Broekman; Eugene T. Dillon; Alicia Gómez Sánchez; Sajal K. Minhas; Erwin Wijk; Roxana A. Radu; Gabriel H. Travis; Michelle Carey; Oliver E. Blacque; Breandán N. Kennedy
Published in: The Faseb Journal, Issue 1, 2022, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Author(s): Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltán V. Varga, Zoltán Giricz, Gabriela Salinas, Julia C. Gross & Laura C. Zelarayán
Published in: Communications Biology, Issue 6,79, 2023, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-04402-9

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Author(s): Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Published in: Pharmaceutics, Issue 2023 March 29;15(4):1096, 2023, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Author(s): Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely,1,2,3 Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy,and Zoltán V. Varga
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241813826