Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease

Informations projet

CRYSTAL3

N° de convention de subvention: 101007931

DOI

10.3030/101007931

Projet clôturé

Date de signature de la CE 2 Octobre 2020

Date de début 1 Janvier 2021

Date de fin 31 Decembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 887 800,00

Contribution de l’UE

€ 887 800,00

Coordonné par

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (2)

CRYSTAL3 initiation

Initiation of CRYSTAL3: Kick-off Meeting and Initiation of Secondments

CRYSTAL training material

Dossier and database on training and educational material generated

Documents, reports (3)

New CRYSTAL3 services and products

A report on new services and products and their stage of development

CRYSTAL3 portfolio Part1

Part1 of A portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

CRYSTAL3 portfolio Part2

Part 2 of a portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

Websites, patent fillings, videos etc. (1)

CRYSTAL3 Website and Scocial Media

Launch of CRYSTAL3 social mediawebsite

Publications

Peer reviewed articles (18)

Modulation of Urea Transport Attenuates TLR2-Mediated Microglial Activation and Upregulates Microglial Metabolism In Vitro

Auteurs: Najlaa A. Al-Thani, Dylan Zinck, Gavin S. Stewart, Derek A. Costello
Publié dans: Metabolites, Numéro 14, 2024, Page(s) 634, ISSN 2218-1989
Éditeur: MDPI
DOI: 10.3390/metabo14110634

Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles

Auteurs: Csenger Kovácsházi, Szabolcs Hambalkó, Nabil V. Sayour, Tamás G. Gergely, Gábor B. Brenner, Csilla Pelyhe, Dóra Kapui, Bennet Y. Weber, Alexander L. Hültenschmidt, Éva Pállinger, Edit I. Buzás, Ádám Zolcsák, Bálint Kiss, Tamás Bozó, Csilla Csányi, Nikolett Kósa, Miklós Kellermayer, Róbert Farkas, Gellért B. Karvaly, Kieran Wynne, David Matallanas, Péter Ferdinandy, Zoltán Gi
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-62689-6

Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer

Auteurs: Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren and Lasse D. Jensen
Publié dans: Journal of Experimental & Clinical Cancer Research, Numéro 41, Article number: 58, 2022, ISSN 0392-9078
Éditeur: BioMed Central
DOI: 10.1186/s13046-022-02280-x

Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer

Auteurs: Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Publié dans: npj Precision Oncology, Numéro 8, 2024, ISSN 2397-768X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41698-024-00550-9

Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication

Auteurs: Ellie Swords, Breandán N. Kennedy, Valentina Tonelotto
Publié dans: Frontiers in Pharmacology, Numéro 15, 2024, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1466896

1,4-dihydroxy quininib activates ferroptosis pathways inmetastatic uveal melanoma and reveals a novel prognosticbiomarker signature

Auteurs: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly1, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon4, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey and Breandán N. Kennedy.
Publié dans: Cell Death Discovery, 2024, ISSN 2058-7716
Éditeur: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Discovery and Development of the Quininib Series of Ocular Drugs

Auteurs: Niamh Mahon, Kayleigh Slater, Justine O'Brien, Yolanda Alvarez, Alison Reynolds, and Breandán Kennedy
Publié dans: Journal of Ocular Pharmacology and Therapeutics, Numéro 38, 1, 2022, ISSN 1080-7683
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/jop.2021.0074

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Auteurs: Husvinee Sundaramurthi, Zoltán Giricz, and Breandán N. Kennedy
Publié dans: International Journal of Molecular Sciences, Numéro Volume 13, Numéro 16, 2022, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169378

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Auteurs: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Publié dans: Open Research Europe, Numéro 1, 2021, Page(s) 92, ISSN 2732-5121
Éditeur: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Auteurs: Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O'Connell, Eve O’Reilly, Marcel Costa-Garcia, Csenger Kovácsházi, Agnes Kittel, Simone Marcone, Alfonso Blanco, Eva Pallinger, Szabolcs Hambalkó, Jose Maria Piulats Rodriguez, Péter Ferdinandy , Jacintha O'Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, and Breandán N. Kennedy
Publié dans: Open Research Europe, 2023, ISSN 2732-5121
Éditeur: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15973.1

An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue

Auteurs: Federico Bleckwedel, Giulia Germena, Laura C. Zelarayán
Publié dans: Trillium Extracellular Vesicles, 2022, ISSN 2698-8739
Éditeur: Trillium-Verlag
DOI: 10.47184/tev.2022.01.03

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Auteurs: Alicia Gómez Sánchez, Patrizia Colucci, Ailis Moran, Alexandro Moya López, Basilio Colligris, Yolanda Álvarez and Breandán N. Kennedy
Publié dans: Open Research Europe, 2023, ISSN 2732-5121
Éditeur: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15491.1

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Auteurs: Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D Jensen
Publié dans: Cells, Numéro 2023 Feb 3;12(3):508, 2023, ISSN 2073-4409
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells12030508

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Auteurs: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Publié dans: Cancers, Numéro 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Auteurs: Ailís L. Moran; Stephen P. Carter; Joanna J. Kaylor; Zhichun Jiang; Sanne Broekman; Eugene T. Dillon; Alicia Gómez Sánchez; Sajal K. Minhas; Erwin Wijk; Roxana A. Radu; Gabriel H. Travis; Michelle Carey; Oliver E. Blacque; Breandán N. Kennedy
Publié dans: The Faseb Journal, Numéro 1, 2022, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Auteurs: Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltán V. Varga, Zoltán Giricz, Gabriela Salinas, Julia C. Gross & Laura C. Zelarayán
Publié dans: Communications Biology, Numéro 2023 Jan 21;6(1):79, 2023, ISSN 2399-3642
Éditeur: Springer Nature
DOI: 10.1038/s42003-022-04402-9

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Auteurs: Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Publié dans: Pharmaceutics, Numéro 2023 March 29;15(4):1096, 2023, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Auteurs: Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely,1,2,3 Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy,and Zoltán V. Varga
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241813826