Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease

Informazioni relative al progetto

CRYSTAL3

ID dell’accordo di sovvenzione: 101007931

DOI

10.3030/101007931

Progetto chiuso

Data della firma CE 2 Ottobre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 887 800,00

Contributo UE

€ 887 800,00

Coordinato da

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (2)

CRYSTAL3 initiation

Initiation of CRYSTAL3: Kick-off Meeting and Initiation of Secondments

CRYSTAL training material

Dossier and database on training and educational material generated

Documents, reports (3)

New CRYSTAL3 services and products

A report on new services and products and their stage of development

CRYSTAL3 portfolio Part1

Part1 of A portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

CRYSTAL3 portfolio Part2

Part 2 of a portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

Websites, patent fillings, videos etc. (1)

CRYSTAL3 Website and Scocial Media

Launch of CRYSTAL3 social mediawebsite

Pubblicazioni

Peer reviewed articles (18)

Modulation of Urea Transport Attenuates TLR2-Mediated Microglial Activation and Upregulates Microglial Metabolism In Vitro

Autori: Najlaa A. Al-Thani, Dylan Zinck, Gavin S. Stewart, Derek A. Costello
Pubblicato in: Metabolites, Numero 14, 2024, Pagina/e 634, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo14110634

Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles

Autori: Csenger Kovácsházi, Szabolcs Hambalkó, Nabil V. Sayour, Tamás G. Gergely, Gábor B. Brenner, Csilla Pelyhe, Dóra Kapui, Bennet Y. Weber, Alexander L. Hültenschmidt, Éva Pállinger, Edit I. Buzás, Ádám Zolcsák, Bálint Kiss, Tamás Bozó, Csilla Csányi, Nikolett Kósa, Miklós Kellermayer, Róbert Farkas, Gellért B. Karvaly, Kieran Wynne, David Matallanas, Péter Ferdinandy, Zoltán Gi
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-62689-6

Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer

Autori: Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren and Lasse D. Jensen
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 41, Article number: 58, 2022, ISSN 0392-9078
Editore: BioMed Central
DOI: 10.1186/s13046-022-02280-x

Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer

Autori: Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Pubblicato in: npj Precision Oncology, Numero 8, 2024, ISSN 2397-768X
Editore: Nature Publishing Group
DOI: 10.1038/s41698-024-00550-9

Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication

Autori: Ellie Swords, Breandán N. Kennedy, Valentina Tonelotto
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1466896

1,4-dihydroxy quininib activates ferroptosis pathways inmetastatic uveal melanoma and reveals a novel prognosticbiomarker signature

Autori: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly1, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon4, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey and Breandán N. Kennedy.
Pubblicato in: Cell Death Discovery, 2024, ISSN 2058-7716
Editore: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Discovery and Development of the Quininib Series of Ocular Drugs

Autori: Niamh Mahon, Kayleigh Slater, Justine O'Brien, Yolanda Alvarez, Alison Reynolds, and Breandán Kennedy
Pubblicato in: Journal of Ocular Pharmacology and Therapeutics, Numero 38, 1, 2022, ISSN 1080-7683
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/jop.2021.0074

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Autori: Husvinee Sundaramurthi, Zoltán Giricz, and Breandán N. Kennedy
Pubblicato in: International Journal of Molecular Sciences, Numero Volume 13, Numero 16, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169378

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Autori: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Pubblicato in: Open Research Europe, Numero 1, 2021, Pagina/e 92, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Autori: Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O'Connell, Eve O’Reilly, Marcel Costa-Garcia, Csenger Kovácsházi, Agnes Kittel, Simone Marcone, Alfonso Blanco, Eva Pallinger, Szabolcs Hambalkó, Jose Maria Piulats Rodriguez, Péter Ferdinandy , Jacintha O'Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, and Breandán N. Kennedy
Pubblicato in: Open Research Europe, 2023, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15973.1

An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue

Autori: Federico Bleckwedel, Giulia Germena, Laura C. Zelarayán
Pubblicato in: Trillium Extracellular Vesicles, 2022, ISSN 2698-8739
Editore: Trillium-Verlag
DOI: 10.47184/tev.2022.01.03

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Autori: Alicia Gómez Sánchez, Patrizia Colucci, Ailis Moran, Alexandro Moya López, Basilio Colligris, Yolanda Álvarez and Breandán N. Kennedy
Pubblicato in: Open Research Europe, 2023, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15491.1

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Autori: Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D Jensen
Pubblicato in: Cells, Numero 2023 Feb 3;12(3):508, 2023, ISSN 2073-4409
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells12030508

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Autori: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Pubblicato in: Cancers, Numero 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Autori: Ailís L. Moran; Stephen P. Carter; Joanna J. Kaylor; Zhichun Jiang; Sanne Broekman; Eugene T. Dillon; Alicia Gómez Sánchez; Sajal K. Minhas; Erwin Wijk; Roxana A. Radu; Gabriel H. Travis; Michelle Carey; Oliver E. Blacque; Breandán N. Kennedy
Pubblicato in: The Faseb Journal, Numero 1, 2022, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Autori: Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltán V. Varga, Zoltán Giricz, Gabriela Salinas, Julia C. Gross & Laura C. Zelarayán
Pubblicato in: Communications Biology, Numero 2023 Jan 21;6(1):79, 2023, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-022-04402-9

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Autori: Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Pubblicato in: Pharmaceutics, Numero 2023 March 29;15(4):1096, 2023, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Autori: Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely,1,2,3 Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy,and Zoltán V. Varga
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241813826