Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease

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Initiation of CRYSTAL3: Kick-off Meeting and Initiation of Secondments

Part1 of A portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

Launch of CRYSTAL3 social mediawebsite

Pubblicazioni

Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer

Autori: Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren and Lasse D. Jensen
Pubblicato in: Journal of Experimental & Clinical Cancer Research, Numero 41, Article number: 58, 2022, ISSN 0392-9078
Editore: BioMed Central
DOI: 10.1186/s13046-022-02280-x

1,4-dihydroxy quininib activates ferroptosis pathways inmetastatic uveal melanoma and reveals a novel prognosticbiomarker signature

Autori: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly1, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon4, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey and Breandán N. Kennedy.
Pubblicato in: Cell Death Discovery, 2024, ISSN 2058-7716
Editore: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Discovery and Development of the Quininib Series of Ocular Drugs

Autori: Niamh Mahon, Kayleigh Slater, Justine O'Brien, Yolanda Alvarez, Alison Reynolds, and Breandán Kennedy
Pubblicato in: Journal of Ocular Pharmacology and Therapeutics, Numero 38, 1, 2022, ISSN 1080-7683
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/jop.2021.0074

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Autori: Husvinee Sundaramurthi, Zoltán Giricz, and Breandán N. Kennedy
Pubblicato in: International Journal of Molecular Sciences, Numero Volume 13, Numero 16, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169378

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Autori: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Pubblicato in: Open Research Europe, Numero 1, 2021, Pagina/e 92, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Autori: Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O'Connell, Eve O’Reilly, Marcel Costa-Garcia, Csenger Kovácsházi, Agnes Kittel, Simone Marcone, Alfonso Blanco, Eva Pallinger, Szabolcs Hambalkó, Jose Maria Piulats Rodriguez, Péter Ferdinandy , Jacintha O'Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, and Breandán N. Kennedy
Pubblicato in: Open Research Europe, 2023, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15973.1

An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue

Autori: Federico Bleckwedel, Giulia Germena, Laura C. Zelarayán
Pubblicato in: Trillium Extracellular Vesicles, 2022, ISSN 2698-8739
Editore: Trillium-Verlag
DOI: 10.47184/tev.2022.01.03

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Autori: Alicia Gómez Sánchez, Patrizia Colucci, Ailis Moran, Alexandro Moya López, Basilio Colligris, Yolanda Álvarez and Breandán N. Kennedy
Pubblicato in: Open Research Europe, 2023, ISSN 2732-5121
Editore: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15491.1

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Autori: Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D Jensen
Pubblicato in: Cells, Numero 2023 Feb 3;12(3):508, 2023, ISSN 2073-4409
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells12030508

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Autori: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Pubblicato in: Cancers, Numero 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Autori: Ailís L. Moran; Stephen P. Carter; Joanna J. Kaylor; Zhichun Jiang; Sanne Broekman; Eugene T. Dillon; Alicia Gómez Sánchez; Sajal K. Minhas; Erwin Wijk; Roxana A. Radu; Gabriel H. Travis; Michelle Carey; Oliver E. Blacque; Breandán N. Kennedy
Pubblicato in: The Faseb Journal, Numero 1, 2022, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Autori: Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltán V. Varga, Zoltán Giricz, Gabriela Salinas, Julia C. Gross & Laura C. Zelarayán
Pubblicato in: Communications Biology, Numero 6,79, 2023, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-022-04402-9

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Autori: Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Pubblicato in: Pharmaceutics, Numero 2023 March 29;15(4):1096, 2023, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Autori: Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely,1,2,3 Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy,and Zoltán V. Varga
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241813826

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