Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease

Información del proyecto

CRYSTAL3

Identificador del acuerdo de subvención: 101007931

DOI

10.3030/101007931

Proyecto cerrado

Fecha de la firma de la CE 2 Octubre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 887 800,00

Aportación de la UE

€ 887 800,00

Coordinado por

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (2)

CRYSTAL3 initiation

Initiation of CRYSTAL3: Kick-off Meeting and Initiation of Secondments

CRYSTAL training material

Dossier and database on training and educational material generated

Documents, reports (3)

New CRYSTAL3 services and products

A report on new services and products and their stage of development

CRYSTAL3 portfolio Part1

Part1 of A portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

CRYSTAL3 portfolio Part2

Part 2 of a portfolio of new collaborations and market opportunities for services and products from CRYSTAL3 research

Websites, patent fillings, videos etc. (1)

CRYSTAL3 Website and Scocial Media

Launch of CRYSTAL3 social mediawebsite

Publicaciones

Peer reviewed articles (18)

Modulation of Urea Transport Attenuates TLR2-Mediated Microglial Activation and Upregulates Microglial Metabolism In Vitro

Autores: Najlaa A. Al-Thani, Dylan Zinck, Gavin S. Stewart, Derek A. Costello
Publicado en: Metabolites, Edición 14, 2024, Página(s) 634, ISSN 2218-1989
Editor: MDPI
DOI: 10.3390/metabo14110634

Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles

Autores: Csenger Kovácsházi, Szabolcs Hambalkó, Nabil V. Sayour, Tamás G. Gergely, Gábor B. Brenner, Csilla Pelyhe, Dóra Kapui, Bennet Y. Weber, Alexander L. Hültenschmidt, Éva Pállinger, Edit I. Buzás, Ádám Zolcsák, Bálint Kiss, Tamás Bozó, Csilla Csányi, Nikolett Kósa, Miklós Kellermayer, Róbert Farkas, Gellért B. Karvaly, Kieran Wynne, David Matallanas, Péter Ferdinandy, Zoltán Gi
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-62689-6

Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer

Autores: Zaheer Ali, Malin Vildevall, Gabriela Vazquez Rodriguez, Decky Tandiono, Ioannis Vamvakaris, Georgios Evangelou, Georgios Lolas, Konstantinos N. Syrigos, Alberto Villanueva, Michael Wick, Shenga Omar, Anna Erkstam, Julia Schueler, Anna Fahlgren and Lasse D. Jensen
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 41, Article number: 58, 2022, ISSN 0392-9078
Editor: BioMed Central
DOI: 10.1186/s13046-022-02280-x

Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer

Autores: Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Publicado en: npj Precision Oncology, Edición 8, 2024, ISSN 2397-768X
Editor: Nature Publishing Group
DOI: 10.1038/s41698-024-00550-9

Assessment of ferroptosis as a promising candidate for metastatic uveal melanoma treatment and prognostication

Autores: Ellie Swords, Breandán N. Kennedy, Valentina Tonelotto
Publicado en: Frontiers in Pharmacology, Edición 15, 2024, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1466896

1,4-dihydroxy quininib activates ferroptosis pathways inmetastatic uveal melanoma and reveals a novel prognosticbiomarker signature

Autores: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly1, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon4, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey and Breandán N. Kennedy.
Publicado en: Cell Death Discovery, 2024, ISSN 2058-7716
Editor: Nature Publishing Group
DOI: 10.1038/s41420-023-01773-8

Discovery and Development of the Quininib Series of Ocular Drugs

Autores: Niamh Mahon, Kayleigh Slater, Justine O'Brien, Yolanda Alvarez, Alison Reynolds, and Breandán Kennedy
Publicado en: Journal of Ocular Pharmacology and Therapeutics, Edición 38, 1, 2022, ISSN 1080-7683
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/jop.2021.0074

Evaluation of the Therapeutic Potential of Histone Deacetylase 6 Inhibitors for Primary and Metastatic Uveal Melanoma

Autores: Husvinee Sundaramurthi, Zoltán Giricz, and Breandán N. Kennedy
Publicado en: International Journal of Molecular Sciences, Edición Volume 13, Edición 16, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23169378

Affordable and effective optokinetic response methods to assess visual acuity and contrast sensitivity in larval to juvenile zebrafish

Autores: Alicia Gómez Sánchez, Yolanda Álvarez, Basilio Colligris, Breandán N. Kennedy
Publicado en: Open Research Europe, Edición 1, 2021, Página(s) 92, ISSN 2732-5121
Editor: European Commission Open Research Europe
DOI: 10.12688/openreseurope.13923.1

Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes

Autores: Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O'Connell, Eve O’Reilly, Marcel Costa-Garcia, Csenger Kovácsházi, Agnes Kittel, Simone Marcone, Alfonso Blanco, Eva Pallinger, Szabolcs Hambalkó, Jose Maria Piulats Rodriguez, Péter Ferdinandy , Jacintha O'Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, and Breandán N. Kennedy
Publicado en: Open Research Europe, 2023, ISSN 2732-5121
Editor: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15973.1

An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue

Autores: Federico Bleckwedel, Giulia Germena, Laura C. Zelarayán
Publicado en: Trillium Extracellular Vesicles, 2022, ISSN 2698-8739
Editor: Trillium-Verlag
DOI: 10.47184/tev.2022.01.03

Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis

Autores: Alicia Gómez Sánchez, Patrizia Colucci, Ailis Moran, Alexandro Moya López, Basilio Colligris, Yolanda Álvarez and Breandán N. Kennedy
Publicado en: Open Research Europe, 2023, ISSN 2732-5121
Editor: European Commission Open Research Europe
DOI: 10.12688/openreseurope.15491.1

Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer

Autores: Saskia Kowald, Ylva Huge, Decky Tandiono, Zaheer Ali, Gabriela Vazquez-Rodriguez, Anna Erkstam, Anna Fahlgren, Amir Sherif, Yihai Cao, Lasse D Jensen
Publicado en: Cells, Edición 2023 Feb 3;12(3):508, 2023, ISSN 2073-4409
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells12030508

Uveal Melanoma Cell Line Proliferation Is Inhibited by Ricolinostat, a Histone Deacetylase Inhibitor

Autores: Husvinee Sundaramurthi, Sandra García-Mulero, Valentina Tonelotto , Kayleigh Slater, Simone Marcon, Josep M. Piulats, Ronald WilliamWatson, Desmond J. Tobin, Lasse D. Jensen and Breandán N. Kennedy
Publicado en: Cancers, Edición 2022 Feb; 14(3): 782, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14030782

Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28

Autores: Ailís L. Moran; Stephen P. Carter; Joanna J. Kaylor; Zhichun Jiang; Sanne Broekman; Eugene T. Dillon; Alicia Gómez Sánchez; Sajal K. Minhas; Erwin Wijk; Roxana A. Radu; Gabriel H. Travis; Michelle Carey; Oliver E. Blacque; Breandán N. Kennedy
Publicado en: The Faseb Journal, Edición 1, 2022, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202101897r

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Autores: Eric Schoger, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius, Maren Sitte, Christof Lenz, Mostafa Samak, Rabea Hinkel, Zoltán V. Varga, Zoltán Giricz, Gabriela Salinas, Julia C. Gross & Laura C. Zelarayán
Publicado en: Communications Biology, Edición 2023 Jan 21;6(1):79, 2023, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-022-04402-9

Neuroprotective Nanoparticles Targeting the Retina: A Polymeric Platform for Ocular Drug Delivery Applications

Autores: Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Publicado en: Pharmaceutics, Edición 2023 March 29;15(4):1096, 2023, ISSN 1999-4923
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15041096

Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction

Autores: Nabil V. Sayour, Viktória É. Tóth, Regina N. Nagy, Imre Vörös, Tamás G. Gergely,1,2,3 Zsófia Onódi, Noémi Nagy, Csaba Bödör, Barnabás Váradi, Mihály Ruppert, Tamás Radovits, Federico Bleckwedel, Laura C. Zelarayán, Pal Pacher, Bence Ágg, Anikó Görbe, Péter Ferdinandy,and Zoltán V. Varga
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241813826