Heavy Ion Therapy Research Integration plus

Deliverables

The General Assembly GA the Technical Project board TPB the External Scientific Advisory Board ESAB the Advisory Board for Ethical Legal Industrial Issues ABELII the Central Project Office CPO and the User Selection Panel USP will be proposed and approved

HITRIplus delivers 100 hrs of research TNA by month 18

HITRIplus delivers 100 hrs of research TNA by month 18 Treatment of 10 patients with heavy ion therapy in TA by month 18

Review of promising innovative heavy ion therapy approaches to be brought to the clinics and Trial protocol for innovative heavy ion therapy concept

Review of promising innovative heavy ion therapy approaches to be brought to the clinics

Conceptual Design Report for a patient chair capable of rotating the patient around a vertical axis as well as a vertical in-room imaging system

From market and literature research recommendations and specifications are assembled into a CDR on vertical patient positioning and imaging The CDR should support a later procurement of a patient system in a clinical center The design of the SEEIIST facility will be taken as a baseline environment

Value propositions

Promotional text and visual material aimed at describing the added value of HITRIplus technologies for companies

Magnet Assessment for SC accelerator and gantry

Report on assessment of magnet types suitable for fast SC synchrotron and for SC gantry and preliminary evaluation

Data Management Plan

The data management plan describing the data management life cycle for the data to be collected processed andor generated within HITRIplus project will be definedIn addition concerning the use of personal data this deliverable will report how all of the data they intend to process is relevant and limited to the purposes of the research project in accordance with the data minimisation principlea description of the technical and organisational measures that will be implemented to safeguard the rights and freedoms of the data subjectsresearch participants a description of the security measures that will be implemented to prevent unauthorised access to personal data or the equipment used for processingdescription of the anonymysationpseudonymisation techniques that will be implementedDetailed information on the informed consent procedures in regard to data processing must and templates of the informed consent forms and information sheets in language and terms intelligible to the participants will be kept on file and made available upon request

Dissemination to the community about the possibility of the TA and access to clinical research with patients from EU - through out

Inform medical and research communities about the existence and actions of Transnational Access and contribute to create awareness on heavy ion therapy through a dynamic and interactive websitePromote awareness and understanding of heavy ion therapy needs of particle therapy in the community at large by organizing events talks lectures webinars workshops outreach via social networks An institutional video adaptable to the different communication methods wil be an effective tool

Delivery of specialised training courses

Delivery of two one-week training courses on heavy ion therapy research by specialists in the field. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Provision of e-learning courses

Conversion of the training courses and masterclasses into e-learning courses. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Organisation of secondments and internships: calendar of events

Organisation of secondments and internships in current heavy ion therapy research infrastructures. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Design study on novel treatment room control systems

Design novel treatment control system, which will increase patient safety, increase treatment quality, lower the total treatment time, and ensure easy operation and smooth clinical workflows.

Particle arc therapy delivery to a small scale demonstrator of a rotational patient positioning system for gantry-free delivery with a position feedback integrated to the DDS

Using the demonstrator from M9.1, a particle arc therapy plan is delivered to a mouse-like phantom, to perform technical evaluation as well as assess dosimetric benefits in comparison to conventional fields.

Publications

FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

Author(s): Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante
Published in: Radiotherapy and Oncology, Issue 01678140, 2022, Page(s) 185-190, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.003

Head and neck cancers: reporting indications and results of hadrontherapy of a dual beam facility

Author(s): Barbara Vischioni, Maria Bonora, Sara Ronchi, Rossana Ingargiola, Anna Maria Camarda, Sara Lillo, Eleonora Rossi, Mattia Pecorilla, Stefania Russo, Alfredo Mirandola, Sara Imparato, Silvia Molinelli & Ester Orlandi
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00843-w

Towards multiple energy extraction operation in ion beam therapy

Author(s): R. Steinbrügge, T. Haberer, A. Peters, C. Schoemers
Published in: JACoW IPAC, 2023, ISSN 2673-5490
Publisher: JACoW
DOI: 10.18429/jacow-ipac2023-thpm063

Emerging technologies for cancer therapy using accelerated particles

Author(s): Christian Graeff, Lennart Volz, Marco Durante
Published in: Prog Part Nucl Phys., 2023, ISSN 0146-6410
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ppnp.2023.104046

European projects join forces to investigate the next generation of ion therapy magnets

Author(s): E. De Matteis
Published in: Accelerating News, Issue 39, 2022, ISSN 2296-6536
Publisher: CERN

Magnet Technology and Design of Superconducting Magnets for Heavy Ion Gantry for Hadron Therapy

Author(s): L. Rossi, D. Barna, A. G. Carloni, E. De Matteis, S. Farinon, E. Felcini, E. Gautheron, M. Karppinen, G. Kirby, T. Lecrevisse, R. Musenich, D. Perini, M. Prioli, M. Pullia, S. Sorti and D. Tommasini
Published in: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2687/9/092009

Gantries for carbon ions

Author(s): M. G. Pullia, E. Felcini, E. Benedetto, L. Dassa, E. De Matteis, M. Donetti, G. Frisella, M. Karppinen, C. Kurfurst, S. Mariotto, A. Mereghetti, A. Mirandola, A. Pella, D. Perini, L. Piacentini, M. T. F. Pivi, M. Prioli, A. Ratkus, L. Rossi, L. Sabbatini, S. Savazzi, M. Stock, T. Torims, S. Uberti, R. Valente, A. Vannozzi & M. Vretenar
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00870-7

Diamond based integrated detection system for dosimetric and microdosimetric characterization of radiotherapy ion beams

Author(s): Claudio Verona, Sandra Barna, Dietmar Georg, Yasmin Hamad, Giulio Magrin, Marco Marinelli, Cynthia Meouchi, Gianluca Verona Rinati
Published in: Medical Physics, 2023, ISSN 0094-2405
Publisher: American Association of Physicists in Medicine
DOI: 10.1002/mp.16698

Straight and Curved Canted Cosine Theta Superconducting Dipoles for Ion Therapy: Comparison Between Various Design Options and Technologies for Ramping Operation

Author(s): Matteis, E De; Barna, D; Ceruti, G; Kirby, G ; Lecrevisse, T; Mariotto, S; Perini, D; Prioli, M; Rossi, L; Scibor, K; Statera, M ; Sorbi, M; Sorti, S; Toral, F ; Valente, R
Published in: IEEE Transactions on Applied Superconductivity, 2023, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2023.3259330

Physics and biomedical challenges of cancer therapy with accelerated heavy ions

Author(s): Marco Durante, Jürgen Debus, Jay S. Loeffler
Published in: Nature Reviews Physics, 2021, ISSN 2522-5820
Publisher: Springer Nature
DOI: 10.1038/s42254-021-00368-5

A New Algorithm for Optimizing the Field Quality of Curved CCT Magnets

Author(s): Dora Veres; Tamas Vaszary; Elena Benedetto; Daniel Barna
Published in: Crossref, Issue 10518223, 2022, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3162389

Hadron Therapy Achievements and Challenges: The CNAO Experience

Author(s): Sandro Rossi
Published in: Physics, Issue 26248174, 2022, Page(s) 229-257, ISSN 2624-8174
Publisher: MDPI
DOI: 10.3390/physics4010017

ENLIGHT (European Network for Light Ion Hadron Therapy) and its role in Hadron therapy

Author(s): Petya Georgieva & Manjit Dosanjh
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00837-8

Explorative Studies of an Innovative Superconducting Gantry

Author(s): Pullia, M.G.; Donetti, M.; Felcini, E.; Frisella, G.; Mereghetti, A.; Mirandola, A.; Pella, A.; Savazzi, S.; Dassa, L.; Karppinen, M.; Perini, D.; Tommasini, D.; Vretenar, M.; Kürfürst, C.; Pivi, M.T.F.; Stock, M.; De Matteis, E.; Mariotto, S.; Prioli, M.; Rossi, L.; Sabbatini, L.; Vannozzi, A.; Piacentini, L.; Ratkus, A.; Torims, T.; Vilcans, J.; Benedetto, E.; Uberti, S.
Published in: Journals of Accelerator Conferences Website, Issue 8, 2022, Page(s) 2966-2969, ISSN 2673-5490
Publisher: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS012

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Author(s): Volz L, Reidel C-A, Durante M, Prezado Y, Schuy C, Weber U, Graeff C
Published in: Instruments, 2023, ISSN 2410-390X
Publisher: MDPI AG

Considerations for Upright Particle Therapy Patient Positioning and Associated Image Guidance

Author(s): Lennart Volz, Yinxiangzi Sheng, Marco Durante, Christian Graeff
Published in: Frontiers in Oncology, Issue 2234943X, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.930850

Experimental characterisation and comparison of two Si-based compactsetups for proton imaging of small animals for image-guided proton irradiation

Author(s): Guyue Hu, Angelica Noto , Katrin Schnurle , Matthias Wurl, Franz Siegfried Englbrecht , Johannes Gebhard, Jonathan Bortfeldt, Mateusz Sitarz , Per Poulsen , Katia Parodi
Published in: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, ISSN 2331-5180
Publisher: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2.

The Superconducting Shield (SuShi) Septum Magnet Prototype

Author(s): D. Barna; J. Borburgh; M. Atanasov; G. Kirby; G. Giunchi; V. Karpati; M. Szucs; G. Szabo; V. Mertinger
Published in: Crossref, Issue 10518223, 2022, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3149726

Treatment Planning: comparing techniques and standards

Author(s): Silvia Molinelli, Alfredo Mirandola, Giuseppe Magro, Stefania Russo, Alessandro Vai, Eleonora Rossi, Alessia Bazani, Luca Trombetta, Matteo Bagnalasta, Ester Orlandi & Mario Ciocca
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00845-8

New technologies: superconducting magnets

Author(s): Ernesto De Matteis
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00849-4

Monte Carlo simulation model of the SIRMIO beamline and experimentalvalidation in clinical facilities

Author(s): Ze Huang, Jonathan Bortfeldt, Neeraj Kurichiyanil, Katrin Schnurle , Franz S. Englbrecht, Thomas Rosch, Sairos Safai , Mateusz Sitarz , Katia Parodi, Marco Pinto
Published in: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, Page(s) 289, ISSN 2331-5180
Publisher: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2

Comparison of 352 MHz linac structures for injection into an ion therapy accelerator

Author(s): L. Nikitovic , T. Torims and M. Vretenar
Published in: 10.1088/1742-6596/2687/5/052011, 2024, ISSN 1742-6588
Publisher: Institute of Physics

Status of Nb-Ti CCT Magnet EU Programs for Hadron Therapy

Author(s): F Toral, F. D Barna, C Calzolaio, A Carloni, G Ceruti, E De Matteis, G Kirby, T Lecrevisse, S Mariotto, J Munilla, D Perini, M Prioli, L Rossi, M Statera, M Sorbi, S Sorti, RU Valente
Published in: IEEE Transactions on Applied Superconductivity, 2024, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2023.3349252

Focus stacking single-event particle radiography for high spatial resolution images and 3D feature localization

Author(s): Lennart Volz , Christian Graeff , Marco Durante , Charles-Antoine Collins-Fekete
Published in: Physics in Medicine & Biology, 2024, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ad131a

The Heavy Ions Therapy Research Integration plus project

Author(s): Facoetti A, Rossi S.
Published in: Health and Technology, 2024, ISSN 2190-7188
Publisher: Springer Verlag
DOI: 10.1007/s12553-024-00841-y

Explorative studies of an innovative superconducting gantry

Author(s): M G Pullia, E Benedetto, L Dassa, E De Matteis, M Donetti, E Felcini, G Frisella, M Karppinen, C Kurfürst, S Mariotto
Published in: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2420/1/012099

Electromagnetic Losses in Fast-Ramped Canted-Cosine-Theta Magnets

Author(s): Sorti, Stefano ; Ceruti, Gabriele ; De Matteis, Ernesto ; Mariotto, Samuele ; Prioli, Marco ; Rossi, Lucio ; Sorbi, Massimo ; Valente, Riccardo U.
Published in: IEEE Transactions on Applied Superconductivity, 2024, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2024.3360933

Comparative Study on Scenarios for Rotating Gantry Mechanical Structures

Author(s): Luca Piacentini, Luca Dassa, Diego Perini, Andris Ratkus, Toms Torims, Stefano Uberti, Janis Vilcans, Maurizio Vretenar
Published in: Open Research Europe, Issue 2, 2022, Page(s) 55, ISSN 2732-5121
Publisher: --

Alvarez Drift Tube Linac for Medical Applications in the Framework of Hitriplus Project

Author(s): A. Mamaras, D. Sampsonidis, L. Bellan, G. Bisoffi, M. Comunian, P. A. Thonet and M. Vretenar. J
Published in: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2687/5/052010

Training the future in HITRIplus project: A report on specialised course onheavy ion therapy research

Author(s): Manjit Dosanjh, Angelica Facoetti , Maria Monica Necchi , Nicholas Sammut , Joseph Bateman, Kristaps Palskis, Taylor Rebecca, Cameron Robertson
Published in: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, Page(s) 218, ISSN 2331-5180
Publisher: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2

Innovations in the Next Generation Medical Accelerators for Therapy with Ion Beams

Author(s): E Benedetto and M Vretenar
Published in: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2687/9/092003

Accelerators for health: from current to dream machines

Author(s): A. Faus Golfe, E. Benedetto
Published in: Europhysics News, Issue 53:3, 2022, Page(s) 16-17, ISSN 0531-7479
Publisher: European Physical Society

A European Collaboration to Investigate Superconducting Magnets for Next Generation Heavy Ion Therapy

Author(s): Rossi, L. and Ballarino, A. and Barna, D. and Benedetto, E. and Calzolaio, C. and Ceruti, G. and De Matteis, E. and Echeandia, A. and Ekelof, T. and Farinon, S. and Felcini, E. and Gehring, M. and Kirby, G. and Lecrevisse, T. and Lucas, J. and Mariotto, S. and Munilla, J. and Musenich, R. and Pampaloni, A. and Pepitone, K. and Perini, D. and Popovic, D. and Prioli, M. and Pullia, M. and Quettier,
Published in: IEEE Transactions on Applied Superconductivity, Issue 32: 4, 2022, Page(s) 1-7, ISSN 1051-8223
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3147433

Slow Extraction Modelling for NIMMS Hadron Therapy Synchrotrons

Author(s): Taylor, R.; Benedetto, E.; Sapinski, M.; Pasternak, J.
Published in: Journals of Accelerator Conferences Website, 2022, Page(s) 2988-2991, ISBN 978-3-95450-227-1
Publisher: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS019

Conceptual design of a compact synchrotron-based facility for cancer therapy and biomedical research with helium and proton beams

Author(s): Vretenar, M; Angoletta, M E; Borburgh, J; Bottura, L; Taylor, R; Tranquille, G; Benedetto, E; Torims, T; Paļskis, K; Sapinski, M; Radziņa, M; Adliene, D; Korobeinikova, E; Kalniņa, M
Published in: 14th International Particle Accelerator Conference, 2023, Page(s) 5024-5027, ISBN 978-3-95450-231-8
Publisher: Journals of Accelerator Conferences Website (JACoW)
DOI: 10.18429/jacow-ipac2023-thpm058

Beam optics studies for a novel gantry for hadron therapy

Author(s): Felcini, E.; Frisella, G.; Mereghetti, A; Pullia, M.G.; Savazzi, S.; Pivi, M.T.F:; Benedetto, E.
Published in: Journals of Accelerator Conferences Website, 2022, Page(s) 2962-2965, ISBN 978-3-95450-227-1
Publisher: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS011

Linac Design within HITRIPlus for Particle Therapy

Author(s): Ratzinger, U.; Koubek, B.; Podlech, H.; Vretenar, M.
Published in: Linac2022, Liverpool, UK, 28.08-2.09.2022, Issue 5, 2022
Publisher: --
DOI: 10.5281/zenodo.7225625

HEAVY ION THERAPY MASTERCLASS SCHOOL AND CAPACITYBUILDING FOR FUTURE ION RESEARCH AND THERAPYFACILITIES

Author(s): Panagiota FOKA
Published in: International Conference on Accelerators for Research and Sustainable Development, 2023, Page(s) 86
Publisher: IAEA

Carbon Ion Gantry layout and optics solutions

Author(s): S.Savazzi, E.Felcini, G. Frisella, A.Mereghetti, M.G.Pullia
Published in: NIMMS NOTE 007, 2022
Publisher: CERN

Carbon ion compact medical synchrotron: key parameters

Author(s): E. Benedetto
Published in: CERN NIMMS-Note-008, 2022
Publisher: CERN

Preliminary design of SEEIIST High Energy Beam Transfer lines. M. Sapinski. May-22

Author(s): M. Sapinski
Published in: NIMMS-Note- CERN-ACC-Note-, Issue 0010, 2022
Publisher: CERN

Deliverables

Publications

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