Heavy Ion Therapy Research Integration plus

Livrables

The General Assembly GA the Technical Project board TPB the External Scientific Advisory Board ESAB the Advisory Board for Ethical Legal Industrial Issues ABELII the Central Project Office CPO and the User Selection Panel USP will be proposed and approved

HITRIplus delivers 100 hrs of research TNA by month 18

HITRIplus delivers 100 hrs of research TNA by month 18 Treatment of 10 patients with heavy ion therapy in TA by month 18

Review of promising innovative heavy ion therapy approaches to be brought to the clinics and Trial protocol for innovative heavy ion therapy concept

Review of promising innovative heavy ion therapy approaches to be brought to the clinics

Conceptual Design Report for a patient chair capable of rotating the patient around a vertical axis as well as a vertical in-room imaging system

From market and literature research recommendations and specifications are assembled into a CDR on vertical patient positioning and imaging The CDR should support a later procurement of a patient system in a clinical center The design of the SEEIIST facility will be taken as a baseline environment

Value propositions

Promotional text and visual material aimed at describing the added value of HITRIplus technologies for companies

Magnet Assessment for SC accelerator and gantry

Report on assessment of magnet types suitable for fast SC synchrotron and for SC gantry and preliminary evaluation

Data Management Plan

The data management plan describing the data management life cycle for the data to be collected processed andor generated within HITRIplus project will be definedIn addition concerning the use of personal data this deliverable will report how all of the data they intend to process is relevant and limited to the purposes of the research project in accordance with the data minimisation principlea description of the technical and organisational measures that will be implemented to safeguard the rights and freedoms of the data subjectsresearch participants a description of the security measures that will be implemented to prevent unauthorised access to personal data or the equipment used for processingdescription of the anonymysationpseudonymisation techniques that will be implementedDetailed information on the informed consent procedures in regard to data processing must and templates of the informed consent forms and information sheets in language and terms intelligible to the participants will be kept on file and made available upon request

Dissemination to the community about the possibility of the TA and access to clinical research with patients from EU - through out

Inform medical and research communities about the existence and actions of Transnational Access and contribute to create awareness on heavy ion therapy through a dynamic and interactive websitePromote awareness and understanding of heavy ion therapy needs of particle therapy in the community at large by organizing events talks lectures webinars workshops outreach via social networks An institutional video adaptable to the different communication methods wil be an effective tool

Delivery of specialised training courses

Delivery of two one-week training courses on heavy ion therapy research by specialists in the field. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Provision of e-learning courses

Conversion of the training courses and masterclasses into e-learning courses. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Organisation of secondments and internships: calendar of events

Organisation of secondments and internships in current heavy ion therapy research infrastructures. The delivery date assigned will comprise the reports collected in the various intervals mentioned in the submitted file.

Design study on novel treatment room control systems

Design novel treatment control system, which will increase patient safety, increase treatment quality, lower the total treatment time, and ensure easy operation and smooth clinical workflows.

Particle arc therapy delivery to a small scale demonstrator of a rotational patient positioning system for gantry-free delivery with a position feedback integrated to the DDS

Using the demonstrator from M9.1, a particle arc therapy plan is delivered to a mouse-like phantom, to perform technical evaluation as well as assess dosimetric benefits in comparison to conventional fields.

Publications

FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model

Auteurs: Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante
Publié dans: Radiotherapy and Oncology, Numéro 01678140, 2022, Page(s) 185-190, ISSN 0167-8140
Éditeur: Elsevier BV
DOI: 10.1016/j.radonc.2022.05.003

Head and neck cancers: reporting indications and results of hadrontherapy of a dual beam facility

Auteurs: Barbara Vischioni, Maria Bonora, Sara Ronchi, Rossana Ingargiola, Anna Maria Camarda, Sara Lillo, Eleonora Rossi, Mattia Pecorilla, Stefania Russo, Alfredo Mirandola, Sara Imparato, Silvia Molinelli & Ester Orlandi
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00843-w

Towards multiple energy extraction operation in ion beam therapy

Auteurs: R. Steinbrügge, T. Haberer, A. Peters, C. Schoemers
Publié dans: JACoW IPAC, 2023, ISSN 2673-5490
Éditeur: JACoW
DOI: 10.18429/jacow-ipac2023-thpm063

Emerging technologies for cancer therapy using accelerated particles

Auteurs: Christian Graeff, Lennart Volz, Marco Durante
Publié dans: Prog Part Nucl Phys., 2023, ISSN 0146-6410
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ppnp.2023.104046

European projects join forces to investigate the next generation of ion therapy magnets

Auteurs: E. De Matteis
Publié dans: Accelerating News, Numéro 39, 2022, ISSN 2296-6536
Éditeur: CERN

Magnet Technology and Design of Superconducting Magnets for Heavy Ion Gantry for Hadron Therapy

Auteurs: L. Rossi, D. Barna, A. G. Carloni, E. De Matteis, S. Farinon, E. Felcini, E. Gautheron, M. Karppinen, G. Kirby, T. Lecrevisse, R. Musenich, D. Perini, M. Prioli, M. Pullia, S. Sorti and D. Tommasini
Publié dans: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Éditeur: Institute of Physics
DOI: 10.1088/1742-6596/2687/9/092009

Gantries for carbon ions

Auteurs: M. G. Pullia, E. Felcini, E. Benedetto, L. Dassa, E. De Matteis, M. Donetti, G. Frisella, M. Karppinen, C. Kurfurst, S. Mariotto, A. Mereghetti, A. Mirandola, A. Pella, D. Perini, L. Piacentini, M. T. F. Pivi, M. Prioli, A. Ratkus, L. Rossi, L. Sabbatini, S. Savazzi, M. Stock, T. Torims, S. Uberti, R. Valente, A. Vannozzi & M. Vretenar
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00870-7

Diamond based integrated detection system for dosimetric and microdosimetric characterization of radiotherapy ion beams

Auteurs: Claudio Verona, Sandra Barna, Dietmar Georg, Yasmin Hamad, Giulio Magrin, Marco Marinelli, Cynthia Meouchi, Gianluca Verona Rinati
Publié dans: Medical Physics, 2023, ISSN 0094-2405
Éditeur: American Association of Physicists in Medicine
DOI: 10.1002/mp.16698

Straight and Curved Canted Cosine Theta Superconducting Dipoles for Ion Therapy: Comparison Between Various Design Options and Technologies for Ramping Operation

Auteurs: Matteis, E De; Barna, D; Ceruti, G; Kirby, G ; Lecrevisse, T; Mariotto, S; Perini, D; Prioli, M; Rossi, L; Scibor, K; Statera, M ; Sorbi, M; Sorti, S; Toral, F ; Valente, R
Publié dans: IEEE Transactions on Applied Superconductivity, 2023, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2023.3259330

Physics and biomedical challenges of cancer therapy with accelerated heavy ions

Auteurs: Marco Durante, Jürgen Debus, Jay S. Loeffler
Publié dans: Nature Reviews Physics, 2021, ISSN 2522-5820
Éditeur: Springer Nature
DOI: 10.1038/s42254-021-00368-5

A New Algorithm for Optimizing the Field Quality of Curved CCT Magnets

Auteurs: Dora Veres; Tamas Vaszary; Elena Benedetto; Daniel Barna
Publié dans: Crossref, Numéro 10518223, 2022, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3162389

Hadron Therapy Achievements and Challenges: The CNAO Experience

Auteurs: Sandro Rossi
Publié dans: Physics, Numéro 26248174, 2022, Page(s) 229-257, ISSN 2624-8174
Éditeur: MDPI
DOI: 10.3390/physics4010017

ENLIGHT (European Network for Light Ion Hadron Therapy) and its role in Hadron therapy

Auteurs: Petya Georgieva & Manjit Dosanjh
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00837-8

Explorative Studies of an Innovative Superconducting Gantry

Auteurs: Pullia, M.G.; Donetti, M.; Felcini, E.; Frisella, G.; Mereghetti, A.; Mirandola, A.; Pella, A.; Savazzi, S.; Dassa, L.; Karppinen, M.; Perini, D.; Tommasini, D.; Vretenar, M.; Kürfürst, C.; Pivi, M.T.F.; Stock, M.; De Matteis, E.; Mariotto, S.; Prioli, M.; Rossi, L.; Sabbatini, L.; Vannozzi, A.; Piacentini, L.; Ratkus, A.; Torims, T.; Vilcans, J.; Benedetto, E.; Uberti, S.
Publié dans: Journals of Accelerator Conferences Website, Numéro 8, 2022, Page(s) 2966-2969, ISSN 2673-5490
Éditeur: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS012

Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

Auteurs: Volz L, Reidel C-A, Durante M, Prezado Y, Schuy C, Weber U, Graeff C
Publié dans: Instruments, 2023, ISSN 2410-390X
Éditeur: MDPI AG

Considerations for Upright Particle Therapy Patient Positioning and Associated Image Guidance

Auteurs: Lennart Volz, Yinxiangzi Sheng, Marco Durante, Christian Graeff
Publié dans: Frontiers in Oncology, Numéro 2234943X, 2022, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.930850

Experimental characterisation and comparison of two Si-based compactsetups for proton imaging of small animals for image-guided proton irradiation

Auteurs: Guyue Hu, Angelica Noto , Katrin Schnurle , Matthias Wurl, Franz Siegfried Englbrecht , Johannes Gebhard, Jonathan Bortfeldt, Mateusz Sitarz , Per Poulsen , Katia Parodi
Publié dans: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, ISSN 2331-5180
Éditeur: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2.

The Superconducting Shield (SuShi) Septum Magnet Prototype

Auteurs: D. Barna; J. Borburgh; M. Atanasov; G. Kirby; G. Giunchi; V. Karpati; M. Szucs; G. Szabo; V. Mertinger
Publié dans: Crossref, Numéro 10518223, 2022, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3149726

Treatment Planning: comparing techniques and standards

Auteurs: Silvia Molinelli, Alfredo Mirandola, Giuseppe Magro, Stefania Russo, Alessandro Vai, Eleonora Rossi, Alessia Bazani, Luca Trombetta, Matteo Bagnalasta, Ester Orlandi & Mario Ciocca
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00845-8

New technologies: superconducting magnets

Auteurs: Ernesto De Matteis
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00849-4

Monte Carlo simulation model of the SIRMIO beamline and experimentalvalidation in clinical facilities

Auteurs: Ze Huang, Jonathan Bortfeldt, Neeraj Kurichiyanil, Katrin Schnurle , Franz S. Englbrecht, Thomas Rosch, Sairos Safai , Mateusz Sitarz , Katia Parodi, Marco Pinto
Publié dans: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, Page(s) 289, ISSN 2331-5180
Éditeur: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2

Comparison of 352 MHz linac structures for injection into an ion therapy accelerator

Auteurs: L. Nikitovic , T. Torims and M. Vretenar
Publié dans: 10.1088/1742-6596/2687/5/052011, 2024, ISSN 1742-6588
Éditeur: Institute of Physics

Status of Nb-Ti CCT Magnet EU Programs for Hadron Therapy

Auteurs: F Toral, F. D Barna, C Calzolaio, A Carloni, G Ceruti, E De Matteis, G Kirby, T Lecrevisse, S Mariotto, J Munilla, D Perini, M Prioli, L Rossi, M Statera, M Sorbi, S Sorti, RU Valente
Publié dans: IEEE Transactions on Applied Superconductivity, 2024, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2023.3349252

Focus stacking single-event particle radiography for high spatial resolution images and 3D feature localization

Auteurs: Lennart Volz , Christian Graeff , Marco Durante , Charles-Antoine Collins-Fekete
Publié dans: Physics in Medicine & Biology, 2024, ISSN 0031-9155
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1361-6560/ad131a

The Heavy Ions Therapy Research Integration plus project

Auteurs: Facoetti A, Rossi S.
Publié dans: Health and Technology, 2024, ISSN 2190-7188
Éditeur: Springer Verlag
DOI: 10.1007/s12553-024-00841-y

Explorative studies of an innovative superconducting gantry

Auteurs: M G Pullia, E Benedetto, L Dassa, E De Matteis, M Donetti, E Felcini, G Frisella, M Karppinen, C Kurfürst, S Mariotto
Publié dans: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Éditeur: Institute of Physics
DOI: 10.1088/1742-6596/2420/1/012099

Electromagnetic Losses in Fast-Ramped Canted-Cosine-Theta Magnets

Auteurs: Sorti, Stefano ; Ceruti, Gabriele ; De Matteis, Ernesto ; Mariotto, Samuele ; Prioli, Marco ; Rossi, Lucio ; Sorbi, Massimo ; Valente, Riccardo U.
Publié dans: IEEE Transactions on Applied Superconductivity, 2024, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2024.3360933

Comparative Study on Scenarios for Rotating Gantry Mechanical Structures

Auteurs: Luca Piacentini, Luca Dassa, Diego Perini, Andris Ratkus, Toms Torims, Stefano Uberti, Janis Vilcans, Maurizio Vretenar
Publié dans: Open Research Europe, Numéro 2, 2022, Page(s) 55, ISSN 2732-5121
Éditeur: --

Alvarez Drift Tube Linac for Medical Applications in the Framework of Hitriplus Project

Auteurs: A. Mamaras, D. Sampsonidis, L. Bellan, G. Bisoffi, M. Comunian, P. A. Thonet and M. Vretenar. J
Publié dans: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Éditeur: Institute of Physics
DOI: 10.1088/1742-6596/2687/5/052010

Training the future in HITRIplus project: A report on specialised course onheavy ion therapy research

Auteurs: Manjit Dosanjh, Angelica Facoetti , Maria Monica Necchi , Nicholas Sammut , Joseph Bateman, Kristaps Palskis, Taylor Rebecca, Cameron Robertson
Publié dans: Proceedings to the 61st Annual Conference of the Particle Therapy Cooperative Group, 2023, Page(s) 218, ISSN 2331-5180
Éditeur: Elsevier
DOI: 10.14338/ijpt-23-ptcog61-10.2

Innovations in the Next Generation Medical Accelerators for Therapy with Ion Beams

Auteurs: E Benedetto and M Vretenar
Publié dans: Journal of Physics: Conference Series, 2024, ISSN 1742-6588
Éditeur: Institute of Physics
DOI: 10.1088/1742-6596/2687/9/092003

Accelerators for health: from current to dream machines

Auteurs: A. Faus Golfe, E. Benedetto
Publié dans: Europhysics News, Numéro 53:3, 2022, Page(s) 16-17, ISSN 0531-7479
Éditeur: European Physical Society

A European Collaboration to Investigate Superconducting Magnets for Next Generation Heavy Ion Therapy

Auteurs: Rossi, L. and Ballarino, A. and Barna, D. and Benedetto, E. and Calzolaio, C. and Ceruti, G. and De Matteis, E. and Echeandia, A. and Ekelof, T. and Farinon, S. and Felcini, E. and Gehring, M. and Kirby, G. and Lecrevisse, T. and Lucas, J. and Mariotto, S. and Munilla, J. and Musenich, R. and Pampaloni, A. and Pepitone, K. and Perini, D. and Popovic, D. and Prioli, M. and Pullia, M. and Quettier,
Publié dans: IEEE Transactions on Applied Superconductivity, Numéro 32: 4, 2022, Page(s) 1-7, ISSN 1051-8223
Éditeur: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tasc.2022.3147433

Slow Extraction Modelling for NIMMS Hadron Therapy Synchrotrons

Auteurs: Taylor, R.; Benedetto, E.; Sapinski, M.; Pasternak, J.
Publié dans: Journals of Accelerator Conferences Website, 2022, Page(s) 2988-2991, ISBN 978-3-95450-227-1
Éditeur: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS019

Conceptual design of a compact synchrotron-based facility for cancer therapy and biomedical research with helium and proton beams

Auteurs: Vretenar, M; Angoletta, M E; Borburgh, J; Bottura, L; Taylor, R; Tranquille, G; Benedetto, E; Torims, T; Paļskis, K; Sapinski, M; Radziņa, M; Adliene, D; Korobeinikova, E; Kalniņa, M
Publié dans: 14th International Particle Accelerator Conference, 2023, Page(s) 5024-5027, ISBN 978-3-95450-231-8
Éditeur: Journals of Accelerator Conferences Website (JACoW)
DOI: 10.18429/jacow-ipac2023-thpm058

Beam optics studies for a novel gantry for hadron therapy

Auteurs: Felcini, E.; Frisella, G.; Mereghetti, A; Pullia, M.G.; Savazzi, S.; Pivi, M.T.F:; Benedetto, E.
Publié dans: Journals of Accelerator Conferences Website, 2022, Page(s) 2962-2965, ISBN 978-3-95450-227-1
Éditeur: JACoW Publishing
DOI: 10.18429/JACoW-IPAC2022-THPOMS011

Linac Design within HITRIPlus for Particle Therapy

Auteurs: Ratzinger, U.; Koubek, B.; Podlech, H.; Vretenar, M.
Publié dans: Linac2022, Liverpool, UK, 28.08-2.09.2022, Numéro 5, 2022
Éditeur: --
DOI: 10.5281/zenodo.7225625

HEAVY ION THERAPY MASTERCLASS SCHOOL AND CAPACITYBUILDING FOR FUTURE ION RESEARCH AND THERAPYFACILITIES

Auteurs: Panagiota FOKA
Publié dans: International Conference on Accelerators for Research and Sustainable Development, 2023, Page(s) 86
Éditeur: IAEA

Carbon Ion Gantry layout and optics solutions

Auteurs: S.Savazzi, E.Felcini, G. Frisella, A.Mereghetti, M.G.Pullia
Publié dans: NIMMS NOTE 007, 2022
Éditeur: CERN

Carbon ion compact medical synchrotron: key parameters

Auteurs: E. Benedetto
Publié dans: CERN NIMMS-Note-008, 2022
Éditeur: CERN

Preliminary design of SEEIIST High Energy Beam Transfer lines. M. Sapinski. May-22

Auteurs: M. Sapinski
Publié dans: NIMMS-Note- CERN-ACC-Note-, Numéro 0010, 2022
Éditeur: CERN

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