Project description DEENESFRITPL Advancing multiphoton microscopy for deeper and faster biomedical imaging The development of new therapeutic strategies for different types of diseases requires dedicated instruments capable of encompassing biological problems in their entirety by monitoring them at all relevant length- and timescales. The EU-funded FAIR CHARM project aims at providing two complementary imaging solutions, SWIM and SLIDE, which transform the capacity to capture in real-time the biological processes as well as the cellular and extracellular structures involved in disease onset and progression. While the SWIM microscope uses novel laser sources in the infrared wavelength region around 1700 nm to penetrate deeper into biological tissue, the SLIDE microscope pushes the boundaries of fast multiphoton microscopy to imaging rates in excess of several thousand images per second. Show the project objective Hide the project objective Objective The emergence of innovative research avenues in biomedicine in the last decades (cell therapy, cancer immunotherapy, bio-nanotechnology) has led to many proof-of-principle demonstrations fostering the hope for new therapeutic strategies for diseases. However, the translation from a laboratory bench into clinical practice has often proven unproductive. One of the reasons for this failure in translation is in the absence of imaging instruments capable of encompassing both the subcellular length-scale, where pathogenic disorders are set in, and that of tissues with differentiated cell types required to organize spatial and temporal functionality. An instrument enabling translation should allow resolving three-dimensional features within this large spatial range and operating with the same physical observables at each length scale, also enabling millisecond temporal resolution to monitor relevant processes. These requirements are essential to elucidate the hierarchical and temporal connections between micro and macro structures and events. Multiphoton microscopy has a yet undiscovered potential to fulfill these needs. FAIR CHARM aims at bringing this technique to its full capacity by i) providing access to millimetre imaging depths by building a microscope (SWIM) with excitation in the Short-Wave Infrared Region relying on new laser sources, optimized optics, and ad hoc labelling probes; ii) enabling unprecedented acquisition frame-rates (kHz/s) by the Spectro-temporal Laser Imaging by Diffracted Excitation (SLIDE) approach; iii) adapting Deep Learning recognition algorithms to multiphoton observables. The consortium features photonics innovators, worldwide renown enterprises in laser technology and microscopy, and clinical and biomedical end-users selected within the oncology/immunology, regenerative medicine, and neural signalling fields to provide the scientific push and timely feedback during the development of the final devices: SWIM and SLIDE. Fields of science natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesbasic medicinephysiologymedical and health sciencesbasic medicineimmunologyimmunotherapymedical and health sciencesmedical biotechnologycells technologiesnatural sciencesphysical sciencesopticslaser physics Keywords multiphoton microscopy clinical translation short-wave infrared cytometry Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-36-2020 - Disruptive photonics technologies Call for proposal H2020-ICT-2018-20 See other projects for this call Sub call H2020-ICT-2020-2 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITE DE GENEVE Net EU contribution € 822 233,75 Address Rue du general dufour 24 1211 Geneve Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAET zu LUEBECK Germany Net EU contribution € 979 408,75 Address Ratzeburger allee 160 23562 Lubeck See on map Region Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SZEGEDI BIOLOGIAI KUTATOKOZPONT Hungary Net EU contribution € 298 750,00 Address Temesvari korut 62 6726 Szeged See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LAVISION BIOTEC GMBH Germany Net EU contribution € 792 407,50 Address Astastrasse 14 33617 Bielefeld See on map Region Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LIGHT CONVERSION, UAB Lithuania Net EU contribution € 452 500,00 Address Keramiku g. 2b 10223 Vilnius See on map Region Lietuva Sostinės regionas Vilniaus apskritis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MEDIZINISCHES LASERZENTRUM LUBECK GMBH Germany Net EU contribution € 1 015 642,50 Address Peter monnik weg 4 23562 Lubeck See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany Net EU contribution € 474 960,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 355 692,50 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE France Net EU contribution € 103 136,25 Address Site de la chantrerie, route de gachet 44307 Nantes See on map Region Pays de la Loire Pays de la Loire Loire-Atlantique Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 649 995,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00