Descripción del proyecto
Inteligencia artificial para la prestación de tratamientos inteligentes en hospitales
El objetivo del consorcio de la Unión Europea (UE) AIDPATH es facilitar y mejorar la próxima generación de medicina personalizada con células inmunitarias modificadas por ingeniería genética en hospitales de la UE mediante el uso de tecnología de inteligencia artificial (IA). El ejemplo de realización de células inmunitarias genomodificadas en el contexto de AIDPATH serán linfocitos T, modificados para expresar un receptor quimérico específico de antígeno (T-CAR) sintético, que ya constituyen un tratamiento novedoso y revolucionario en hematología y oncología. En AIDPATH se empleará la tecnología de IA para integrar datos y biomarcadores específicos del paciente en la terapia con T-CAR y optimizar la programación y la planificación de recursos en aras de reducir los costes y la utilización de los recursos hospitalarios. Los miembros del consorcio están bien preparados para entablar un diálogo productivo con los reguladores y los pacientes a fin de garantizar la aceptación y la rápida adopción por parte de los hospitales y la industria de la UE.
Objetivo
AIDPATH (Artificial Intelligence-driven, Decentralized Production for Advanced Thera-pies in the Hospital) is a high-energy EU consortium, dedicated to enable and to augment the next-generation of personalized medicine at EU hospitals through the use of AI tech-nology. The exemplary embodiment of gene-engineered immune cells in AIDPATH will be T cells expressing a synthetic chimeric antigen receptor (CAR-T). These cells are already a revolutionary novel treatment in hematology and oncology, and will also be useful for treating infections and autoimmune diseases. Conventional CAR-T therapy is complicated by complex logistics from centralized manufacturing facilities, inflexible manufacturing and clinical use schemes that disregard patient and cell characteristics, thus limiting patient access and therapeutic outcome.
AIDPATH will apply top-notch AI technology to integrate patient-specific data and biomarkers in CAR-T therapy, and apply flexible manufacturing schemes to obtain CAR-T cell products with optimal fitness and anti-tumor potency. AI technology will be applied in pre- and in-process controls to reduce cost and hospital resource utilization and to augment patient access. AIDPATH will establish a role model that integrates the hospital in a smart manner, incorporating aspects of logistics, capacity planning, data management and cybersecurity by design. The project is designed to enable smart ‘bedside’ provision of personalized treatments and to accomplish end-to-end automation of hospital-based CAR-T manufacture. A key deliverable in AIDPATH will be an integrated cyberphysical infrastructure for rapid dissemination of the ‘smart CAR-T manufacturing and clinical use’ concept to hospitals throughout the EU.
AIDPATH brings together a world-class consortium to address these challenges, consisting of key opinion leaders in science and translational medicine, innovative SMEs and commercial partners, patient advocates, policy makers and regulatory experts.
Ámbito científico
- medical and health sciencesbasic medicineimmunologyautoimmune diseases
- medical and health sciencesclinical medicineoncology
- medical and health scienceshealth sciencespersonalized medicine
- medical and health sciencesclinical medicinehematology
- natural sciencescomputer and information sciencescomputer security
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-DT-2020-1
Régimen de financiación
IA - Innovation actionCoordinador
80686 Munchen
Alemania