Genomics and Personalized Medicine for all though Artificial Intelligence in Haematological Diseases

Risultati finali

Data processing, data management plan and GDPR compliance report

This deliverable will specify the intended data sources data flows and data processing across the consortium and its work plan to form a complete Data Management Plan It will confirm the completion of a DPIA at each relevant partner site and summarise the main areas of risk and mitigation identified It will confirm the legal basis for the processing of each data source noting these will all be special category data and will include copies of approved consent forms in cases where consent is the legal basis

GENOMED4ALL recommendations on the ethical principles, approvals, quality processes and stakeholder engagements for AI development

This deliverable will summarize the recommendations arising from T2.1 and 2.3 on its development of AI, complying with ethical principles and appropriately engaging with patients and other stakeholders. It will also report on the ethics Committee approval is retained from each relevant site, including documentation as deliverable annexes.

Data homogenisation requirements and specifications

This report will define the data homogenisation processes to be included in GENOMED4ALL

GENOMED4ALL training programme definition

This report will be in charge of designing a complete training programme including a 1st definition for training material.

Literature mining and preprocessing.

Literature mining and first AI software release data preprocessing and statistical data cleaning All the software will be open source R Python and C and will be made available for the other project partners

Report 1 of the EAB

This will be the first report of the EAB Including its terms of reference and constitution plus its initial appraisal of the intended data protection human ethics and artificial intelligence approaches

Report 3 of the EAB

This will be the third report of the EAB.

Report 2 of the EAB

This will be the second report of the EAB.

GENOMED4ALL standardization plan

This deliverable will recommend adapt and calibrate data standards for data collected from different clinical partners

GENOMED4ALL Impact Master Plan

A document outlining the project dissemination communication exploitation strategies and detailing the project plan of concrete GENOMED4ALL activities including project website

Preliminary conclusions about federated learning applied to clinical data.

Federated learning software release and report

Interim GENOMED4ALL Dissemination and Communication Report

Documentation of the actions taken, and outcomes achieved in relation to the promotional strategies during the first period of the project, having D9.1 as baseline. This includes the assessment of the Agile Stakeholder Management strategy.

Hybrid Federated learning model.

This deliverable will describe the AI learning mechanisms to make sure a hybrid approach using federated and centralised learning scheme can be applied to GENOMED4ALL

Pubblicazioni

Covering hierarchical Dirichlet mixture models on binary data to enhance genomic stratifications in onco-hematology

Autori: D. D. Olio, E. Sträng, A. T. Turki, J. M. Tettero, M. Barbus, R. Schulze-Rath, J. Martinez, T. Matteuzzi, A. Merlotti, L. Carota, C. Sala, M. G. D. Porta et al.
Pubblicato in: PLOS Computational Biology, Numero Volume 20, 2023, Pagina/e e1011299, ISSN 1553-7358
Editore: PLOS
DOI: 10.1101/2023.06.26.546639

DrOGA: An Artificial Intelligence Solution for Driver-Status Prediction of Genomics Mutations in Precision Cancer Medicine

Autori: M. Bastico; A. Fernández-García; A. Belmonte-Hernández; S. Uribe et al.
Pubblicato in: IEEE Access, Numero Volume 11, 2023, Pagina/e 37378-37391, ISSN 2169-3536
Editore: Institute of Electrical and Electronics Engineers Inc.
DOI: 10.1109/access.2023.3266983

Synthetic Data Generation by Artificial Intelligence to Accelerate Research and Precision Medicine in Hematology

Autori: S. D. Amico, D. D. Olio , C. Sala, L. D. Olio, E. Sauta, M. Zampini et al.
Pubblicato in: JCO Clinical Cancer Informatics, Numero Volume 7, 2023, ISSN 2473-4276
Editore: ASCO publications
DOI: 10.1200/cci.23.00021

Challenges and Opportunities of Precision Medicine in Sickle Cell Disease: Novel European Approach by GenoMed4All Consortium and ERN-EuroBloodNet

Autori: A. Collado, M. P. Boaro, S. van der Veen, A. Idrizovic, B. J. Biemond, D. Beneitez Pastor, A. Ortuño, E. Cela, A. Ruiz-Llobet, P. Bartolucci, M. de Montalembert et al.
Pubblicato in: HemaSphere, Numero 7, 2023, Pagina/e e844-e846, ISSN 2572-9241
Editore: Wiley
DOI: 10.1097/hs9.0000000000000844

Effectiveness of Biologically Inspired Neural Network Models in Learning and Patterns Memorization

Autori: L. Squadrani, N. Curti, E. Giampieri, D. Remondini, B. Blais, G.Castellani
Pubblicato in: Entropy, Numero 24, 2022, ISSN 1099-4300
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e24050682

Random walk approximation for stochastic processes on graphs

Autori: S. Polizzi, T. Marzi, T. Matteuzzi, G. Castellani, A. Bazzani
Pubblicato in: Entropy, Numero 25, 2023, ISSN 1099-4300
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e25030394

Real-world Validation of Molecular International Prognostic Scoring System (IPSS-M) for Myelodysplastic Syndromes

Autori: E. Sauta, M. Robin, M. Bersanelli, E. Travaglino, M. Meggendorfer, L. Zhao et al.
Pubblicato in: Journal of Clinical Oncology, Numero 41, 2023, ISSN 1527-7755
Editore: Asco Publicationes
DOI: 10.1200/jco.22.01784

Synthetic Histopathological Images Generation with Artificial Intelligence to Accelerate Research and Improve Clinical Outcomes in Hematology

Autori: G. Asti, S. D'Amico, N. Curti, G. Carlini, E. Sauta, N. R. Derus, D. Dall'Olio et al.
Pubblicato in: 65th ASH Annual Meeting Proceedings, 2023
Editore: ASH Publications
DOI: 10.1182/blood-2023-187521

Data-Driven Harmonization of 2022 Who and ICC Classifications of Myelodysplastic Syndromes/Neoplasms (MDS): A Study By the International Consortium for MDS (icMDS)

Autori: L. Lanino, S. Ball, J. P. Bewersdorf, M. Marchetti, G. Maggioni, E. Travaglino, N. H. A. Ali, P. Fenaux, U. Platzbecker, V. Santini, M. Diez-Campelo et al.
Pubblicato in: 65th ASH Annual Meeting Proceedings, 2023
Editore: ASH Publications
DOI: 10.1182/blood-2023-186580

Combining Gene Mutation with Transcriptomic Data Improves Outcome Prediction in Myelodysplastic Syndromes

Autori: Combining Gene Mutation with Transcriptomic Data Improves Outcome Prediction in Myelodysplastic Syndromes
Pubblicato in: 65th ASH Annual Meeting Proceedings, 2023
Editore: ASH Publications
DOI: 10.1182/blood-2023-186222

Risultati finali

Pubblicazioni

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