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Individual and Collective Migration of the Immune Cellular System

Project description

Predicting immune cell migration in solid tumours

Immune surveillance depends on the inherent ability of immune cells to migrate to different tissues and carry out immune-related functions. However, the physical characteristics (stiffness and stress) of tumours prohibit the effective infiltration by immune cells, a prerequisite for anti-tumour immune responses under normal conditions and following immunotherapy. The EU-funded ICoMICS project proposes to develop a modelling approach capable of predicting how therapeutic immune cells migrate and interact with the tumour microenvironment. Researchers will employ 3D solid-tumour lung, liver and pancreas organoids that receive specific chemical modulators, and they will combine the generated data with information on tissue mechanics and cell interactions. The ICoMICS platform will contribute to the improvement of immunotherapy outcomes.

Host institution

UNIVERSIDAD DE ZARAGOZA
Net EU contribution
€ 2 494 662,00
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Spain

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Region
Noreste Aragón Zaragoza
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

UNIVERSIDAD DE ZARAGOZA
Spain
Net EU contribution
€ 2 494 662,00
Address
Calle Pedro Cerbuna 12
50009 Zaragoza

See on map

Region
Noreste Aragón Zaragoza
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00