Novel ways to connect the blocks to achieve important organonitrogen compounds
Synthetic chemistry is sort of like building with interlocking blocks – but often the "blocks" resist the connection. When this happens, multiple complex steps can be required, often under harsh reaction conditions, and some combinations may still be inaccessible. Carbon–nitrogen bonds are among the most abundant bonds in organic chemistry and biochemistry. However, simple textbook substitutions are only possible in practice with highly reactive substrates that do not have a lot of "congestion" in the region of the bond of interest. The EU-funded Cu-XAT project is developing a novel route to important yet currently difficult substitution reactions, opening the door to structurally complex and valuable molecules.
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