Description du projet
Le rôle de l’ocytocine dans la communication de cerveau à cerveau
La vision et la communication acoustique sont essentielles dans l’intercommunication des primates. Cependant, la base neuronale de l’acoustique, régulée par la neurohormone appelée ocytocine, reste largement inexplorée, malgré son rôle thérapeutique important dans le comportement social et la coordination de la communication de cerveau à cerveau lors des interactions. C’est dans ce contexte que le projet MarmOT, financé par l’UE, propose une étude axée sur les mécanismes neuronaux et comportementaux dans lesquels l’ocytocine influence la communication acoustique des primates. Le projet combinera les techniques les plus avancées, telles que la manipulation chimio-génétique des neurones à ocytocine et l’électrophysiologie sans fil, et les appliquera à des ouistitis. Les résultats de l’étude auront un impact significatif sur la science.
Objectif
Primates interact with each other primarily through visual and acoustic communication. However, while primate social vision has been extensively studied, little is known about the neuronal basis of acoustic communication in primates. More specifically, we ignore how oxytocin, a neurohormone that regulates social behavior in mammals and a promising therapeutic target for psychiatric disorders, modulates acoustic communication. Based on preliminary evidence, I hypothesize that oxytocin (1) acts in the auditory cortex to increase signal to noise ratio in response to social auditory stimuli, (2) is required for normal communication behavior and (3) is critical to brain-to-brain coordination between two interacting individuals. This Global Fellowship proposal has been designed to unveil how oxytocin influences primates’ acoustic communication at the neuronal and behavioral levels. To do so, I will combine state of the art techniques, such as chemogenetic manipulation of oxytocin neurons and wireless electrophysiology, in marmoset monkeys. This highly vocal primate is key to this project and a rapidly growing animal model in neuroscience. I will learn to work with them during my Outgoing phase in San Diego (USA) and transfer this knowledge back to Europe during the incoming phase, by participating in the inception of a marmoset laboratory in Lyon (France). This project will greatly enhance my career opportunities in academia as it will give me a unique theoretical and technical background. It will place me in a good spot to explore innovative research pathways, with a great potential scientific impact. All the outcomes from MarmOT will be published strictly following the Open Science objective of H2020. Finally, I propose innovative ways to disseminate the results of my experiments in order to reach all types of audience, by collaborating with a local Zoo or contacting Youtubers.
Champ scientifique
Mots‑clés
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
75794 Paris
France