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Topological interactions as functional regulators of the eukaryotic genome: moving beyond intramolecular looping

Project description

Role of the topological interactions in the chromosome biology

Topological interactions between distant DNA segments are fundamental for the eukaryotic genome function. Hi-C is a chromosome conformation capture technique that provides insights into the 3D organisation of the genome. The recently developed sister-chromatid-sensitive Hi-C (scsHi-C) technique demonstrated the potential to elucidate the mechanisms by which sister-chromatid conformation controls DNA repair, gene regulation, and the segregation of mitotic chromosomes. The EU-funded TopoGenomics project aims to develop next-generation scsHi-C technology to obtain high-resolution genome-wide conformation maps of sister chromatids and establish a machine learning-based computational framework to detect topological structures in sister chromatids. The project will advance understanding of the topological interaction of sister chromatids to support the maintenance, expression and segregation of eukaryotic genomes.

Host institution

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Net EU contribution
€ 2 792 500,00
Address
Dr Bohrgasse 3
1030 Wien
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Beneficiaries (1)

INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
Austria
Net EU contribution
€ 2 792 500,00
Address
Dr Bohrgasse 3
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00