Descripción del proyecto
Uso de tejido bioimpreso para prevenir la artrosis
Los trastornos musculoesqueléticos como la artrosis, una afección degenerativa que afecta a millones de personas en todo el mundo, son la causa más importante de dolor crónico, incapacidad y morbilidad. Los tratamientos actuales tienen una eficacia limitada. Pese a que la regeneración musculoesquelética se ha convertido en una importante área de investigación, por el momento las estrategias regeneradoras no han logrado producir tejidos que imiten la exquisita complejidad estructural de los tejidos nativos, lo cual limita de forma drástica su utilidad clínica. En este contexto, el proyecto financiado con fondos europeos 4D-BOUNDARIES utilizará tecnologías de bioimpresión tridimensional para diseñar, por primera vez, injertos de cartílago y menisco para pacientes específicos que reproduzcan la anatomía interna y externa, así como las propiedades mecánicas anisotrópicas de los tejidos nativos. En el caso de la artrosis, la capacidad para bioimprimir estos tejidos funcionales podría impedir el desarrollo de esta afección.
Objetivo
Regeneration of musculoskeletal tissues requires engineered grafts that mimic the heterogeneous and anisotropic structure and mechanics of the native tissue. Despite decades of research, existing regenerative strategies have failed to produce tissues mimicking this exquisite structural complexity, dramatically limiting their clinical utility. Clues to addressing this grand challenge can be found in normal tissue development, which relies upon both the self-organizing potential of stem cells as well as key physical instructions from the microenvironment to establish final tissue architectures. Recognising this, the goal of 4D-BOUNDARIES is to leverage emerging 3D bioprinting technologies to provide precise physical boundary conditions and spatially localised morphogens to self-organizing cells and cellular aggregates to engineer structurally anisotropic and mechanically functional musculoskeletal tissues. To realise this goal, 4D-BOUNDARIES will build upon applicant’s extensive expertise in bioprinting and bioink development to produce two new biofabrication platforms that provide temporary guiding structures to self-organizing tissues. To demonstrate the utility of these bioprinting platforms they will be used to engineer, for the first time, patient-specific cartilage and meniscal grafts that mimic the internal and external anatomy and anisotropic mechanical properties of the native tissues. The ability to bioprint such functional tissues will transform the field of orthopaedic medicine, providing grafts to biologically resurface large areas of damaged articular cartilage and meniscus and thereby prevent the development of osteoarthritis – a debilitating disease affecting millions of people worldwide. The impact of 4D-BOUNDARIES will not be limited to the orthopaedic space, as it is envisioned that these new bioprinting platforms will find numerous applications in tissue engineering and regenerative medicine.
Ámbito científico
Palabras clave
Programa(s)
Régimen de financiación
ERC-ADG - Advanced GrantInstitución de acogida
D02 CX56 DUBLIN 2
Irlanda