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EXTRacEllular matrix MEchanochemistry: a solid-state NMR approach

Project description

The extracellular matrix as a platform for studying tissue mechanical history

The extracellular matrix (ECM) is a complex 3D material that forms a scaffold around cells and determines the mechanical properties of structural tissues like bone, tendon and skin. Recent studies demonstrated that covalent bond breaks in the ECM proteins result in chemical modifications that communicate the mechanical history, embedding specific molecular cues into the ECM structure. The EU-funded EXTREME project aims to elucidate the specifics of the ECM mechanochemical modifications as well as how cells recognise them and how they change in ageing and disease. The project will employ the solid-state nuclear magnetic resonance methodology to determine these modifications in the ECM of intact tissues under mechanical deformations.

Host institution

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Net EU contribution
€ 3 498 825,00
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

See on map

Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 3 498 825,00
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

See on map

Region
East of England East Anglia Cambridgeshire CC
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00