Skip to main content

Plasma epigenomics: A new liquid biopsy paradigm

Project description

Plasma epigenomics as an extension of liquid biopsy technologies

Genomic DNA carries a multitude of post-translational modifications that reflect cells’ transcriptional states. Upon cell death, fragmented chromatin retaining histone modifications is released into circulation. The EU-funded cfChIP project aims to obtain plasma epigenomic information and translate it into medically relevant findings via liquid biopsy and chromatin immunoprecipitation of cell-free nucleosomes with chromatin marks followed by sequencing (cfChIP-seq). The previous study showed that cfChIP-seq provides multidimensional epigenetic information about the identity and the transcriptional state of the originating cells. The project will explore plasma samples from patients and donors in combination with probabilistic modelling to find correlations between tissue gene expressions and circulating chromatin profiles and how the immune system changes with disease progression and response to treatments.

Host institution

THE HEBREW UNIVERSITY OF JERUSALEM
Net EU contribution
€ 2 962 500,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Israel

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Net EU contribution
€ 2 962 500,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00