Exploring a new chemical space
Drug discovery usually involves the identification of active substances from natural sources or the rational synthesis of bioactive compounds through combinatorial chemistry. Modification or development of new synthetic methods is an ongoing effort to provide as many solutions as possible to the medicinal chemistry community. The EU-funded ABASynth project focuses on azabicyclic amines predicted to have great applicability considering the ubiquity of amines in bioactive organic molecules. Researchers will employ various chemical approaches to deliver novel functionalisation and molecular properties to azabicycloalkanes. The work is expected to introduce new chemical substituents of biologically relevant heterocycles with a variety of applications.