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Targeting DNA repair pathways, sparking anti cancer immunity

Publications

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

Author(s): Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A.
Published in: Cell Reports Medicine, Issue 101376, 2024, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2023.101376

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Author(s): Durinikova E, Reilly NM, Buzo K, Mariella E, Chilà R, Lorenzato A, Dias JML, Grasso G, Pisati F, Lamba S, Corti G, Degasperi A, Cancelliere C, Mauri G, Andrei P, Linnebacher M, Marsoni S, Siena S, Sartore-Bianchi A, Nik-Zainal S, Di Nicolantonio F, Bardelli A*, Arena S* (* Shared last authorship)
Published in: Clinical Cancer Research, Issue 28(17), 2022, Page(s) 38-74-3889, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0875

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.

Author(s): Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M.
Published in: Nature Genetics, Issue 54(7), 2022, Page(s) 976-984, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01105-z

Liquid biopsies to monitor and direct cancer treatment in colorectal cancer

Author(s): Mauri G, Vitiello PP, Sogari A, Crisafulli G, Sartore-Bianchi A, Marsoni S, Siena S, Bardelli A.
Published in: British Journal of Cancer, Issue 127(3), 2022, Page(s) 394-407, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-01769-8

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Author(s): Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Published in: Cancer Cell, Issue 41(1), 2023, Page(s) 196-209, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2022.12.003

Precision oncology for KRASG12C-mutant colorectal cancer.

Author(s): Di Nicolantonio F, Bardelli A
Published in: Nature Review Clinical Oncology, Issue 20(6), 2023, Page(s) 355-356, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-023-00748-z

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Author(s): Rospo G, Chilà R, Matafora V, Basso V, Lamba S, Bartolini A, Bachi A, Di Nicolantonio F, Mondino A, Germano G, Bardelli A
Published in: Genome Medicine, Issue 16(1): 15, 2024, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-023-01275-3

Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers.

Author(s): Mauri G, Patelli G, Roazzi L, Valtorta E, Amatu A, Marrapese G, Bonazzina E, Tosi F, Bencardino K, Ciarlo G, Mariella E, Marsoni S, Bardelli A, Bonoldi E, Sartore-Bianchi A, Siena S.
Published in: Journal of Clinical Pathology, Issue jcp-2023-209341, 2024, ISSN 1472-4146
Publisher: BMJ Publishing Group
DOI: 10.1136/jcp-2023-209341

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Author(s): Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, Bartolini A, Fenocchio E, Amatu A, Manca P, Bergamo F, Tosi F, Mauri G, Ambrosini M, Daniel F, Torri V, Vanzulli A, Regge D, Cappello G, Marchiò C, Berrino E, Sapino A, Marsoni S, Siena S, Bardelli A.
Published in: Nature Medicine, Issue 28(8), 2022, Page(s) 1612-1618, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-01886-0

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Author(s): Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A
Published in: Mol Oncol, Issue March 11th, 2024, ISSN 1878-0261
Publisher: Wiley
DOI: 10.1002/1878-0261.13622

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Author(s): Margherita Pergolizzi; Laura Bizzozero; Federica Maione; Elena Maldi; Claudio Isella; Marco Macagno; Elisa Mariella; Alberto Bardelli; Enzo Medico; Caterina Marchiò; Guido Serini; Federica Di Nicolantonio; Federico Bussolino; Marco Arese
Published in: J Exp Clin Cancer Res, Issue 41(1), 2022, Page(s) 266, ISSN 1756-9966
Publisher: BioMed Central (BMC)
DOI: 10.1186/s13046-022-02465-4

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