Targeting DNA repair pathways, sparking anti cancer immunity

Project Information

TARGET

Grant agreement ID: 101020342

DOI

10.3030/101020342

EC signature date 5 July 2021

Start date 1 October 2021

End date 30 September 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 489 232,00

EU contribution

€ 2 489 232,00

Coordinated by

UNIVERSITA DEGLI STUDI DI TORINO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

Author(s): Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A.
Published in: Cell Reports Medicine, Issue 101376, 2024, ISSN 2666-3791
Publisher: Elsevier
DOI: 10.1016/j.xcrm.2023.101376

Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Author(s): Enrico Berrino, Sara Erika Bellomo, Maria Costanza Aquilano, Marta Falcinelli, Anita Chesta, Emanuele Valtorta, Daniela Zampieri, Gianluca Mauri, Giuseppe Sala, Silvia Marsoni, Alberto Bardelli, Andrea Sartore-Bianchi, Salvatore Siena, Anna Sapino, Emanuela Bonoldi, Fabrizio d’Adda di Fagagna, Caterina Marchiò
Published in: The Oncologist, Issue 31, 2026, ISSN 1083-7159
Publisher: AlphaMed Press Inc
DOI: 10.1093/oncolo/oyag116

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

Author(s): Elena Grassi, Valentina Vurchio, George D. Cresswell, Irene Catalano, Barbara Lupo, Francesco Sassi, Francesco Galimi, Sofia Borgato, Martina Ferri, Marco Viviani, Simone Pompei, Gianvito Urgese, Bingjie Chen, Eugenia R. Zanella, Francesca Cottino, Mariangela Russo, Gianluca Mauri, Filippo Pietrantonio, Maria Giulia Zampino, Luca Lazzari, Silvia Marsoni, Alberto Bardelli, Marco Cosentino Lagomarsi
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.ado1641

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Author(s): Durinikova E, Reilly NM, Buzo K, Mariella E, Chilà R, Lorenzato A, Dias JML, Grasso G, Pisati F, Lamba S, Corti G, Degasperi A, Cancelliere C, Mauri G, Andrei P, Linnebacher M, Marsoni S, Siena S, Sartore-Bianchi A, Nik-Zainal S, Di Nicolantonio F, Bardelli A*, Arena S* (* Shared last authorship)
Published in: Clinical Cancer Research, Issue 28(17), 2022, Page(s) 38-74-3889, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0875

Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial

Author(s): E. Elez, S. Siena, A. Sartore-Bianchi, J. Ros, F. Ciardello, E. Martinelli, N. Steeghs, S. Huijberts, A. Cervantes, S. Roselló, S. Tejpar, B. Wilmsen, R. Salazar, C. Santos, G. de Schaetzen, S. Muñoz, R. Bernards, V. Moreno, E. García-Galera, R. Alemany, A. Gros, A. Bardelli, S. Arena, A. Piris, E. Chavarría, R. Dienstmann, J. Tabernero
Published in: ESMO Open, Issue 10, 2026, Page(s) 105892, ISSN 2059-7029
Publisher: Elsevier BV
DOI: 10.1016/j.esmoop.2025.105892

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.

Author(s): Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M.
Published in: Nature Genetics, Issue 54(7), 2022, Page(s) 976-984, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01105-z

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities

Author(s): Mariangela Russo, Mengnuo Chen, Elisa Mariella, Haoning Peng, Sumaiyah K. Rehman, Elena Sancho, Alberto Sogari, Tzen S. Toh, Nathalie Q. Balaban, Eduard Batlle, Rene Bernards, Mathew J. Garnett, Matthew Hangauer, Eleonora Leucci, Jean-Christophe Marine, Catherine A. O’Brien, Yaara Oren, E. Elizabeth Patton, Caroline Robert, Susan M. Rosenberg, Shensi Shen, Alberto Bardelli
Published in: Nature Reviews Cancer, Issue 24, 2024, Page(s) 694-717, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-024-00737-z

DNA repair-dependent immunogenic liabilities in colorectal cancer: opportunities from errors

Author(s): V. Amodio, P. P. Vitiello, A. Bardelli, G. Germano
Published in: British Journal of Cancer, 2024, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-024-02848-8

Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

Author(s): Pietro Paolo Vitiello, Benoit Rousseau, Rosaria Chilà, Paolo Battuello, Vito Amodio, Vittorio Battaglieri, Gaia Grasso, Sharon Scardellato, Achille Anselmo, Francesca Clemente, Giuseppe Rospo, Simona Lamba, Alice Bartolini, Federica Pisati, Claudio Tripodo, Noemi Congiusta, Mariangela Russo, Giovanni Crisafulli, Federica Di Nicolantonio, Giovanni Germano, Luis A. Diaz, Alberto Bardelli
Published in: Cancer Cell, Issue 43, 2025, Page(s) 1296-1312.e7, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2025.05.014

Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients.

Author(s): Crisafulli G, Sartore-Bianchi A, Lazzari L, Pietrantonio F, Amatu A, Macagno M, Barault L, Cassingena A, Bartolini A, Luraghi P, Mauri G, Battuello P, Personeni N, Zampino MG, Pessei V, Vitiello PP, Tosi F, Idotta L, Morano F, Valtorta E, Bonoldi E, Germano G, Di Nicolantonio F, Marsoni S, Siena S, Bardelli A
Published in: Cancer Discovery, Issue 12(7), 2022, Page(s) 1656-1675, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-1434

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Author(s): Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Published in: Cancer Cell, Issue 41(1), 2023, Page(s) 196-209, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2022.12.003

Precision oncology for KRASG12C-mutant colorectal cancer.

Author(s): Di Nicolantonio F, Bardelli A
Published in: Nature Review Clinical Oncology, Issue 20(6), 2023, Page(s) 355-356, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-023-00748-z

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Author(s): Rospo G, Chilà R, Matafora V, Basso V, Lamba S, Bartolini A, Bachi A, Di Nicolantonio F, Mondino A, Germano G, Bardelli A
Published in: Genome Medicine, Issue 16(1): 15, 2024, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-023-01275-3

A subset of <scp>MMR</scp> ‐proficient colon cancers responds to neoadjuvant immunotherapy

Author(s): Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli
Published in: Molecular Oncology, Issue 20, 2026, Page(s) 579-583, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.70178

Mapping intratumor heterogeneity across layers for advancing immunotherapy

Author(s): Jean-Christophe Marine, Osnat Bartok, Shira Sagie, Pietro Paolo Vitiello, Alberto Bardelli, Chen Weller, Tian-Gen Chang, Claudia Tonelli, Stefani Spranger, Eytan Ruppin, Yardena Samuels
Published in: Cell, Issue 189, 2026, Page(s) 2416-2440, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2026.03.025

Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers.

Author(s): Mauri G, Patelli G, Roazzi L, Valtorta E, Amatu A, Marrapese G, Bonazzina E, Tosi F, Bencardino K, Ciarlo G, Mariella E, Marsoni S, Bardelli A, Bonoldi E, Sartore-Bianchi A, Siena S.
Published in: Journal of Clinical Pathology, Issue jcp-2023-209341, 2024, ISSN 1472-4146
Publisher: BMJ Publishing Group
DOI: 10.1136/jcp-2023-209341

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Author(s): Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A
Published in: Mol Oncol, Issue March 11th, 2024, ISSN 1878-0261
Publisher: Wiley
DOI: 10.1002/1878-0261.13622

Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer

Author(s): Eleonora Piumatti, Pietro Paolo Vitiello, Vito Amodio, Alberto Bardelli, Giovanni Germano
Published in: Cancer Research, Issue 85, 2025, Page(s) 4299-4314, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-25-2255

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Author(s): Margherita Pergolizzi; Laura Bizzozero; Federica Maione; Elena Maldi; Claudio Isella; Marco Macagno; Elisa Mariella; Alberto Bardelli; Enzo Medico; Caterina Marchiò; Guido Serini; Federica Di Nicolantonio; Federico Bussolino; Marco Arese
Published in: J Exp Clin Cancer Res, Issue 41(1), 2022, Page(s) 266, ISSN 1756-9966
Publisher: BioMed Central (BMC)
DOI: 10.1186/s13046-022-02465-4

Mutational signatures of colorectal cancers according to distinct computational workflows

Author(s): Paolo Battuello, Giorgio Corti, Alice Bartolini, Annalisa Lorenzato, Alberto Sogari, Mariangela Russo, Federica Di Nicolantonio, Alberto Bardelli, Giovanni Crisafulli
Published in: Briefings in Bioinformatics, Issue 25, 2024, Page(s) 1-13, ISSN 1467-5463
Publisher: Oxford University Press
DOI: 10.1093/bib/bbae249

Mismatch Repair-Proficient Colorectal Cancer can evade Immune Surveillance Through an Intrinsic Suppressive Program

Author(s): Chiara Maria. Cattaneo, Sharon Scardellato, Gianluca Mauri, Vittoria Matafora, Veera K. Ojala, Costanza Cannariato, Rosaria Chila, Zulma Irene Magnani, Wouter Scheper, Luca Lazzari, Emile E. Voest, Maria Chiara Bonini, Angela Bachi, Salvatore Siena, Silvia Marsoni, Giovanni Germano, Alberto Bardelli
Published in: Cancer Discovery, 2026, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-26-0542

Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models.

Author(s): Maione F, Oddo D, Galvagno F, Falcomatà C, Pandini M, Macagno M, Pessei V, Barault L, Gigliotti C, Mira A, Corti G, Lamba S, Riganti C, Castella B, Massaia M, Rad R, Saur D, Bardelli A, Di Nicolantonio F
Published in: Molecular Oncology, 2024, ISSN 1878-0261
Publisher: Wiley
DOI: 10.1002/1878-0261.13595

Pharmacological inhibition of PMS2 induces MMR deficiency and response to immune checkpoint blockade

Author(s): Julian Blagg, Philippe Riou, Alexia Hervieu, Eleonora Piumatti, Maria T. Rodriguez-Plata, Paolo Battuello, Adam Peall, Vito Amodio, Pietro Paolo Vitiello, Daniel J. H. Nightingale, Ruzica Bago, Paige Tongue, Tessa Slater, Kalpesh Parmar, Pradip Patel, Javier Rodríguez González, David E. Clark, Gareth W. Langley, Charles Nichols, Alba Guarne, Paul C.M. Winship, Matthew Baker, Martin Drysdale, Gio
Published in: Cancer Discovery, 2026, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-26-0003