Targeting DNA repair pathways, sparking anti cancer immunity

Publications

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

Auteurs: Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A.
Publié dans: Cell Reports Medicine, Numéro 101376, 2024, ISSN 2666-3791
Éditeur: Elsevier
DOI: 10.1016/j.xcrm.2023.101376

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Auteurs: Durinikova E, Reilly NM, Buzo K, Mariella E, Chilà R, Lorenzato A, Dias JML, Grasso G, Pisati F, Lamba S, Corti G, Degasperi A, Cancelliere C, Mauri G, Andrei P, Linnebacher M, Marsoni S, Siena S, Sartore-Bianchi A, Nik-Zainal S, Di Nicolantonio F, Bardelli A*, Arena S* (* Shared last authorship)
Publié dans: Clinical Cancer Research, Numéro 28(17), 2022, Page(s) 38-74-3889, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0875

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.

Auteurs: Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M.
Publié dans: Nature Genetics, Numéro 54(7), 2022, Page(s) 976-984, ISSN 1061-4036
Éditeur: Nature Publishing Group
DOI: 10.1038/s41588-022-01105-z

Liquid biopsies to monitor and direct cancer treatment in colorectal cancer

Auteurs: Mauri G, Vitiello PP, Sogari A, Crisafulli G, Sartore-Bianchi A, Marsoni S, Siena S, Bardelli A.
Publié dans: British Journal of Cancer, Numéro 127(3), 2022, Page(s) 394-407, ISSN 0007-0920
Éditeur: Nature Publishing Group
DOI: 10.1038/s41416-022-01769-8

Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients.

Auteurs: Crisafulli G, Sartore-Bianchi A, Lazzari L, Pietrantonio F, Amatu A, Macagno M, Barault L, Cassingena A, Bartolini A, Luraghi P, Mauri G, Battuello P, Personeni N, Zampino MG, Pessei V, Vitiello PP, Tosi F, Idotta L, Morano F, Valtorta E, Bonoldi E, Germano G, Di Nicolantonio F, Marsoni S, Siena S, Bardelli A
Publié dans: Cancer Discovery, Numéro 12(7), 2022, Page(s) 1656-1675, ISSN 2159-8274
Éditeur: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-1434

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Auteurs: Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Publié dans: Cancer Cell, Numéro 41(1), 2023, Page(s) 196-209, ISSN 1535-6108
Éditeur: Cell Press
DOI: 10.1016/j.ccell.2022.12.003

Precision oncology for KRASG12C-mutant colorectal cancer.

Auteurs: Di Nicolantonio F, Bardelli A
Publié dans: Nature Review Clinical Oncology, Numéro 20(6), 2023, Page(s) 355-356, ISSN 1759-4774
Éditeur: Nature Publishing Group
DOI: 10.1038/s41571-023-00748-z

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Auteurs: Rospo G, Chilà R, Matafora V, Basso V, Lamba S, Bartolini A, Bachi A, Di Nicolantonio F, Mondino A, Germano G, Bardelli A
Publié dans: Genome Medicine, Numéro 16(1): 15, 2024, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/s13073-023-01275-3

Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers.

Auteurs: Mauri G, Patelli G, Roazzi L, Valtorta E, Amatu A, Marrapese G, Bonazzina E, Tosi F, Bencardino K, Ciarlo G, Mariella E, Marsoni S, Bardelli A, Bonoldi E, Sartore-Bianchi A, Siena S.
Publié dans: Journal of Clinical Pathology, Numéro jcp-2023-209341, 2024, ISSN 1472-4146
Éditeur: BMJ Publishing Group
DOI: 10.1136/jcp-2023-209341

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Auteurs: Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, Bartolini A, Fenocchio E, Amatu A, Manca P, Bergamo F, Tosi F, Mauri G, Ambrosini M, Daniel F, Torri V, Vanzulli A, Regge D, Cappello G, Marchiò C, Berrino E, Sapino A, Marsoni S, Siena S, Bardelli A.
Publié dans: Nature Medicine, Numéro 28(8), 2022, Page(s) 1612-1618, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-022-01886-0

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Auteurs: Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A
Publié dans: Mol Oncol, Numéro March 11th, 2024, ISSN 1878-0261
Éditeur: Wiley
DOI: 10.1002/1878-0261.13622

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Auteurs: Margherita Pergolizzi; Laura Bizzozero; Federica Maione; Elena Maldi; Claudio Isella; Marco Macagno; Elisa Mariella; Alberto Bardelli; Enzo Medico; Caterina Marchiò; Guido Serini; Federica Di Nicolantonio; Federico Bussolino; Marco Arese
Publié dans: J Exp Clin Cancer Res, Numéro 41(1), 2022, Page(s) 266, ISSN 1756-9966
Éditeur: BioMed Central (BMC)
DOI: 10.1186/s13046-022-02465-4

Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models.

Auteurs: Maione F, Oddo D, Galvagno F, Falcomatà C, Pandini M, Macagno M, Pessei V, Barault L, Gigliotti C, Mira A, Corti G, Lamba S, Riganti C, Castella B, Massaia M, Rad R, Saur D, Bardelli A, Di Nicolantonio F
Publié dans: Molecular Oncology, 2024, ISSN 1878-0261
Éditeur: Wiley
DOI: 10.1002/1878-0261.13595

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