Targeting DNA repair pathways, sparking anti cancer immunity

Publicaciones

Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

Autores: Sogari A, Rovera E, Grasso G, Mariella E, Reilly NM, Lamba S, Mauri G, Durinikova E, Vitiello PP, Lorenzato A, Avolio M, Piumatti E, Bonoldi E, Aquilano MC, Arena S, Sartore-Bianchi A, Siena S, Trusolino L, Donalisio M, Russo M, Di Nicolantonio F, Lembo D, Bardelli A.
Publicado en: Cell Reports Medicine, Edición 101376, 2024, ISSN 2666-3791
Editor: Elsevier
DOI: 10.1016/j.xcrm.2023.101376

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.

Autores: Durinikova E, Reilly NM, Buzo K, Mariella E, Chilà R, Lorenzato A, Dias JML, Grasso G, Pisati F, Lamba S, Corti G, Degasperi A, Cancelliere C, Mauri G, Andrei P, Linnebacher M, Marsoni S, Siena S, Sartore-Bianchi A, Nik-Zainal S, Di Nicolantonio F, Bardelli A*, Arena S* (* Shared last authorship)
Publicado en: Clinical Cancer Research, Edición 28(17), 2022, Página(s) 38-74-3889, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-0875

A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells.

Autores: Russo M, Pompei S, Sogari A, Corigliano M, Crisafulli G, Puliafito A, Lamba S, Erriquez J, Bertotti A, Gherardi M, Di Nicolantonio F, Bardelli A, Cosentino Lagomarsino M.
Publicado en: Nature Genetics, Edición 54(7), 2022, Página(s) 976-984, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01105-z

Liquid biopsies to monitor and direct cancer treatment in colorectal cancer

Autores: Mauri G, Vitiello PP, Sogari A, Crisafulli G, Sartore-Bianchi A, Marsoni S, Siena S, Bardelli A.
Publicado en: British Journal of Cancer, Edición 127(3), 2022, Página(s) 394-407, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-01769-8

Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients.

Autores: Crisafulli G, Sartore-Bianchi A, Lazzari L, Pietrantonio F, Amatu A, Macagno M, Barault L, Cassingena A, Bartolini A, Luraghi P, Mauri G, Battuello P, Personeni N, Zampino MG, Pessei V, Vitiello PP, Tosi F, Idotta L, Morano F, Valtorta E, Bonoldi E, Germano G, Di Nicolantonio F, Marsoni S, Siena S, Bardelli A
Publicado en: Cancer Discovery, Edición 12(7), 2022, Página(s) 1656-1675, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-1434

Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Autores: Amodio V, Lamba S, Chilà R, Cattaneo CM, Mussolin B, Corti G, Rospo G, Berrino E, Tripodo C, Pisati F, Bartolini A, Aquilano MC, Marsoni S, Mauri G, Marchiò C, Abrignani S, Di Nicolantonio F, Germano G, Bardelli A.
Publicado en: Cancer Cell, Edición 41(1), 2023, Página(s) 196-209, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2022.12.003

Precision oncology for KRASG12C-mutant colorectal cancer.

Autores: Di Nicolantonio F, Bardelli A
Publicado en: Nature Review Clinical Oncology, Edición 20(6), 2023, Página(s) 355-356, ISSN 1759-4774
Editor: Nature Publishing Group
DOI: 10.1038/s41571-023-00748-z

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Autores: Rospo G, Chilà R, Matafora V, Basso V, Lamba S, Bartolini A, Bachi A, Di Nicolantonio F, Mondino A, Germano G, Bardelli A
Publicado en: Genome Medicine, Edición 16(1): 15, 2024, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-023-01275-3

Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers.

Autores: Mauri G, Patelli G, Roazzi L, Valtorta E, Amatu A, Marrapese G, Bonazzina E, Tosi F, Bencardino K, Ciarlo G, Mariella E, Marsoni S, Bardelli A, Bonoldi E, Sartore-Bianchi A, Siena S.
Publicado en: Journal of Clinical Pathology, Edición jcp-2023-209341, 2024, ISSN 1472-4146
Editor: BMJ Publishing Group
DOI: 10.1136/jcp-2023-209341

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.

Autores: Sartore-Bianchi A, Pietrantonio F, Lonardi S, Mussolin B, Rua F, Crisafulli G, Bartolini A, Fenocchio E, Amatu A, Manca P, Bergamo F, Tosi F, Mauri G, Ambrosini M, Daniel F, Torri V, Vanzulli A, Regge D, Cappello G, Marchiò C, Berrino E, Sapino A, Marsoni S, Siena S, Bardelli A.
Publicado en: Nature Medicine, Edición 28(8), 2022, Página(s) 1612-1618, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-022-01886-0

Transcriptome-wide gene expression outlier analysis pinpoints therapeutic vulnerabilities in colorectal cancer

Autores: Mariella E, Grasso G, Miotto M, Buzo K, Reilly NM, Andrei P, Vitiello PP, Crisafulli G, Arena S, Rospo G, Corti G, Lorenzato A, Cancelliere C, Barault L, Gionfriddo G, Linnebacher M, Russo M, Di Nicolantonio F, Bardelli A
Publicado en: Mol Oncol, Edición March 11th, 2024, ISSN 1878-0261
Editor: Wiley
DOI: 10.1002/1878-0261.13622

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Autores: Margherita Pergolizzi; Laura Bizzozero; Federica Maione; Elena Maldi; Claudio Isella; Marco Macagno; Elisa Mariella; Alberto Bardelli; Enzo Medico; Caterina Marchiò; Guido Serini; Federica Di Nicolantonio; Federico Bussolino; Marco Arese
Publicado en: J Exp Clin Cancer Res, Edición 41(1), 2022, Página(s) 266, ISSN 1756-9966
Editor: BioMed Central (BMC)
DOI: 10.1186/s13046-022-02465-4

Preclinical efficacy of carfilzomib in BRAF-mutant colorectal cancer models.

Autores: Maione F, Oddo D, Galvagno F, Falcomatà C, Pandini M, Macagno M, Pessei V, Barault L, Gigliotti C, Mira A, Corti G, Lamba S, Riganti C, Castella B, Massaia M, Rad R, Saur D, Bardelli A, Di Nicolantonio F
Publicado en: Molecular Oncology, 2024, ISSN 1878-0261
Editor: Wiley
DOI: 10.1002/1878-0261.13595

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