Electrochemical Bond Functionalization

Project Information

ElectroFun

Grant agreement ID: 101021358

DOI

10.3030/101021358

EC signature date 28 July 2021

Start date 1 August 2021

End date 31 July 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 499 423,75

EU contribution

€ 2 499 423,75

Coordinated by

GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (42)

Direct Synthesis of C4-Acyl Indoles via C–H Acylation

Author(s): Bo-Sheng Zhang, Ze-Qiang Zhang, Tian-Jiao Guo, João C. A. Oliveira, Svenja Warratz, Bao-Jie Deng, Yi-Ming Wang, Jun-Shi Zhou, Xue-Ya Gou, Xi-Cun Wang, Zheng-Jun Quan, Lutz Ackermann
Published in: Organic Letters, Issue 26, 2024, Page(s) 4998-5003, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.4c01658

Close‐Shell Reductive Elimination versus Open‐Shell Radical Coupling for Site‐Selective Ruthenium‐Catalyzed C−H Activations by Computation and Experiments

Author(s): Xinran Chen, Hasret Can Gülen, Jun Wu, Zi‐Jing Zhang, Xin Hong, Lutz Ackermann
Published in: Angewandte Chemie International Edition, Issue 62, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202302021

Manganese(I)-Catalyzed C–H Allylation of Tryptophans and Their Oligopeptides On Water

Author(s): Fabrice Gallou, Lutz Ackermann, Julia Struwe, Tsuyoshi Oyama
Published in: Synlett, Issue 35, 2024, Page(s) 903-907, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-2268-4678

Site-selective electrochemical carboxylation of aromatic C(sp2)–H bonds with CO2

Author(s): Rong Zhao, Max Surke, Zhipeng Lin, Ali Alsalme, Lutz Ackermann
Published in: Current Research in Green and Sustainable Chemistry, Issue 7, 2024, Page(s) 100377, ISSN 2666-0865
Publisher: Elsevier
DOI: 10.1016/j.crgsc.2023.100377

Radical cascade cyclization of 1,<i>n</i>-enynes under photo/electrochemical conditions

Author(s): Zhenzhi Cai, Sven Trienes, Kairui Liu, Lutz Ackermann, Yan Zhang
Published in: Organic Chemistry Frontiers, Issue 10, 2024, Page(s) 5735-5745, ISSN 2052-4129
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3qo01482g

Enantioselective electrochemical cobalt-catalyzed aryl C–H activation reactions

Author(s): Tristan von Münchow, Suman Dana, Yang Xu, Binbin Yuan, Lutz Ackermann
Published in: Science, Issue 379, 2024, Page(s) 1036-1042, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adg2866

Metallaelectro-catalyzed alkyne annulations <i>via</i> C–H activations for sustainable heterocycle syntheses

Author(s): Preeti Kushwaha, Anjali Saxena, Tristan von Münchow, Suman Dana, Biswajit Saha, Lutz Ackermann
Published in: Chemical Communications, 2024, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cc03871a

Machine learning-guided yield optimization for palladaelectro-catalyzed annulation reaction

Author(s): Xiaoyan Hou, Shuwen Li, Johanna Frey, Xin Hong, Lutz Ackermann
Published in: Chem, Issue 10, 2024, Page(s) 2283-2294, ISSN 2451-9294
Publisher: Elsevier
DOI: 10.1016/j.chempr.2024.03.027

Combined C-H amination and intermolecular alkyne insertion for a three-component cyclization

Author(s): Bo-Sheng Zhang, Yu-Xi Yang, João C.A. Oliveira, Ze-Qiang Zhang, Svenja Warratz, Yi-Ming Wang, Shun-Xi Li, Xi-Cun Wang, Xue-Ya Gou, Yong-Min Liang, Zheng-Jun Quan, Lutz Ackermann
Published in: Cell Reports Physical Science, Issue 4, 2023, Page(s) 101647, ISSN 2666-3864
Publisher: Elsevier
DOI: 10.1016/j.xcrp.2023.101647

Electrochemical C7‐Indole Alkenylation <i>via</i> Rhodium Catalysis

Author(s): Agnese Zangarelli, Binbin Yuan, Lutz Ackermann
Published in: Israel Journal of Chemistry, Issue 64, 2024, ISSN 0021-2148
Publisher: Laser Pages Publishing Ltd.
DOI: 10.1002/ijch.202300103

Template Synthesis to Solve the Unreachable <i>Ortho</i> C–H Functionalization Reaction of Aryl Iodide

Author(s): Bo-Sheng Zhang, Wan-Yuan Jia, Yi-Ming Wang, João C. A. Oliveira, Svenja Warratz, Ze-Qiang Zhang, Xue-Ya Gou, Yong-Min Liang, Xi-Cun Wang, Zheng-Jun Quan, Lutz Ackermann
Published in: The Journal of Organic Chemistry, Issue 88, 2023, Page(s) 16539-16546, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c02014

Photoinduced C–H arylation of 1,3-azoles <i>via</i> copper/photoredox dual catalysis

Author(s): Sven Trienes, Jiawei Xu, Lutz Ackermann
Published in: Chemical Science, Issue 15, 2024, Page(s) 7293-7299, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc00393d

Weak-coordination-auxiliary aminocatalysis enables directed [3 + 2] cyclization for 2-acylindolizines

Author(s): Kui Zeng, Neeraj Kumar Pandit, João C. A. Oliveira, Sebastian Dechert, Lutz Ackermann, Kai Zhang
Published in: Green Chemistry, Issue 26, 2024, Page(s) 5253-5259, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3gc03552b

Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification

Author(s): Zhipeng Lin, Uttam Dhawa, Xiaoyan Hou, Max Surke, Binbin Yuan, Shu-Wen Li, Yan-Cheng Liou, Magnus J. Johansson, Li-Cheng Xu, Chen-Hang Chao, Xin Hong, Lutz Ackermann
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39747-0

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation

Author(s): Daniele Antermite, Stig D. Friis, Johan R. Johansson, Okky Dwichandra Putra, Lutz Ackermann, Magnus J. Johansson
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43789-9

Photoelectrochemical Iron-Catalyzed C(sp ³ )–H Borylation of Alkanes in a Position-Selective Manner

Author(s): Wen Wei, Bin Wang, Simon L. Homölle, Jinbin Zhu, Yanjun Li, Tristan von Münchow, Isaac Maksso, Lutz Ackermann
Published in: CCS Chemistry, Issue 6, 2024, Page(s) 1430-1438, ISSN 2096-5745
Publisher: Chinese Chemical Society
DOI: 10.31635/ccschem.024.202403894

Photoelectrochemical Si–H and Ge–H activation by iron catalysis

Author(s): Wen Wei, Simon L. Homölle, Tristan von Münchow, Yanjun Li, Isaac Maksso, Lutz Ackermann
Published in: Cell Reports Physical Science, Issue 4, 2024, Page(s) 101550, ISSN 2666-3864
Publisher: Elsevier
DOI: 10.1016/j.xcrp.2023.101550

Nickel-Catalyzed Atroposelective C–H Alkylation Enabled by Bimetallic Catalysis with Air-Stable Heteroatom-Substituted Secondary Phosphine Oxide Preligands

Author(s): Zi-Jing Zhang, Matthias M. Simon, Shuang Yu, Shu-Wen Li, Xinran Chen, Silvia Cattani, Xin Hong, Lutz Ackermann
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 9172-9180, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c14600

Anodic Commodity Polymer Recycling: The Merger of Iron‐Electrocatalysis with Scalable Hydrogen Evolution Reaction

Author(s): Maxime Hourtoule, Sven Trienes, Lutz Ackermann
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202412689

Electrochemical Late-Stage Functionalization

Author(s): Yulei Wang, Suman Dana, Hao Long, Yang Xu, Yanjun Li, Nikolaos Kaplaneris, Lutz Ackermann
Published in: Chemical Reviews, Issue 123, 2023, Page(s) 11269-11335, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.3c00158

The crucial role of silver(<scp>i</scp>)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

Author(s): Renato L. de Carvalho, Emilay B. T. Diogo, Simon L. Homölle, Suman Dana, Eufrânio N. da Silva Júnior, Lutz Ackermann
Published in: Chemical Society Reviews, Issue 52, 2024, Page(s) 6359-6378, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cs00328k

Electrochemical Syntheses of Polycyclic Aromatic Hydrocarbons (PAHs)

Author(s): Yulei Wang, Rong Zhao, Lutz Ackermann
Published in: Advanced Materials, Issue 35, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300760

Bifurcated Rhodaelectro-catalyzed C–H Activation for the Synthesis of Pyrroles and Lactones

Author(s): Simon L. Homölle, Maximilian Stangier, Efraim Reyes, Lutz Ackermann
Published in: Precision Chemistry, Issue 1, 2023, Page(s) 382-387, ISSN 2771-9316
Publisher: American Chemical Society
DOI: 10.1021/prechem.3c00061

Polymer up-cycling by mangana-electrocatalytic C(sp³)–H azidation without directing groups

Author(s): Isaac Maksso, Ramesh C. Samanta, Yifei Zhan, Kai Zhang, Svenja Warratz, Lutz Ackermann
Published in: Chemical Science, Issue 14, 2024, Page(s) 8109-8118, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc02549g

Electrocatalytic Formal C(sp²)−H Alkylations via Nickel‐Catalyzed Cross‐Electrophile Coupling with Versatile Arylsulfonium Salts

Author(s): Takuya Michiyuki, Simon L. Homölle, Neeraj K. Pandit, Lutz Ackermann
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202401198

Electrochemical Rearrangement for Remote Functionalizations of Unactivated Alkenes

Author(s): Dingyi Wang, Binbin Yuan, Jiawei Xu, Lutz Ackermann
Published in: Chemistry – A European Journal, Issue 29, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202300600

Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green, and Efficient Access to Cytotoxic Compounds

Author(s): Emilay B. T. Diogo, Fábio G. Delolo, Gabriela A. P. Graça, Esther R. S. Paz, Ícaro A. O. Bozzi, Renata Diniz, Juliano P. Passos, Tulio Matencio, Liane K. Soares, Diego Alves, Pedro M. S. Costa, Claudia Pessoa, Cynthia L. M. Pereira, Lutz Ackermann, Eufrânio N. da Silva Júnior
Published in: European Journal of Organic Chemistry, Issue 26, 2023, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202300506

Cobaltaelectro-Catalyzed C–H Annulation with Allenes for Atropochiral and <i>P</i>-Stereogenic Compounds: Late-Stage Diversification and Continuous Flow Scale-Up

Author(s): Ye Lin, Tristan von Münchow, Lutz Ackermann
Published in: ACS Catalysis, Issue 13, 2023, Page(s) 9713-9723, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.3c02072

Photoelectrocatalytic [4+2] Annulation for <i>S</i>‐Heterocycle Assembly Enabled by Proton‐Coupled Electron Transfer (PCET)

Author(s): Yuan‐Yuan Cheng, Jiawei Xu, Zhipeng Lin, Yanjun Li, Lutz Ackermann
Published in: Chemistry – A European Journal, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202402333

Recent advances in organic electrochemical functionalizations for specialty chemicals

Author(s): Yanjun Li, Suman Dana, Lutz Ackermann
Published in: Current Opinion in Electrochemistry, Issue 40, 2024, Page(s) 101312, ISSN 2451-9103
Publisher: Elsevier
DOI: 10.1016/j.coelec.2023.101312

Photo‐Induced Ruthenium‐Catalyzed C−H Arylation Polymerization at Ambient Temperature

Author(s): Takuya Michiyuki, Isaac Maksso, Lutz Ackermann
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202400845

Room temperature photo-promoted iron-catalysed arene C–H alkenylation without Grignard reagents

Author(s): Antonis M. Messinis, Tristan von Münchow, Max Surke, Lutz Ackermann
Published in: Nature Catalysis, Issue 7, 2024, Page(s) 273-284, ISSN 2520-1158
Publisher: Springer Nature
DOI: 10.1038/s41929-023-01105-0

Electrochemical assembly of isoxazoles <i>via</i> a four-component domino reaction

Author(s): Yuanyuan Zhao, Xinyue Li, Simon L. Homölle, Bin Wang, Lutz Ackermann
Published in: Chemical Science, Issue 15, 2024, Page(s) 1117-1122, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc05946d

Cobaltaelectro‐Catalyzed C–H Activation for Central and Axial Double Enantio‐Induction

Author(s): Tristan von Münchow, Yi‐Ru Liu, Rahul Parmar, Sven Erik Peters, Sven Trienes, Lutz Ackermann
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202405423

Electrochemical Glycosylation via Halogen-Atom-Transfer for <i>C</i>-Glycoside Assembly

Author(s): Jun Wu, Rajeshwaran Purushothaman, Felix Kallert, Simon L. Homölle, Lutz Ackermann
Published in: ACS Catalysis, Issue 14, 2024, Page(s) 11532-11544, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c02322

Electrochemical Skeletal Indole Editing via Nitrogen Atom Insertion by Sustainable Oxygen Reduction Reaction

Author(s): Bo‐Sheng Zhang, Simon L. Homölle, Tristan Bauch, João C. A. Oliveira, Svenja Warratz, Binbin Yuan, Xue‐Ya Gou, Lutz Ackermann
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407384

Chelation-Assisted Iron-Catalyzed C–H Activations: Scope and Mechanism

Author(s): Jiayu Mo, Antonis M. Messinis, Jinlian Li, Svenja Warratz, Lutz Ackermann
Published in: Accounts of Chemical Research, Issue 57, 2024, Page(s) 10-22, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.3c00294

Enantioselective Cobaltaphotoredox-Catalyzed C–H Activation

Author(s): Yang Xu, Ye Lin, Simon L. Homölle, João C. A. Oliveira, Lutz Ackermann
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 24105-24113, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c08459

Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis

Author(s): Zi-Jing Zhang, Shu-Wen Li, João C. A. Oliveira, Yanjun Li, Xinran Chen, Shuo-Qing Zhang, Li-Cheng Xu, Torben Rogge, Xin Hong, Lutz Ackermann
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38872-0

Electrochemical Enantioselective C–H Annulation by Achiral Rhodium(III)/Chiral Brønsted Base Domino Catalysis

Author(s): Yanjun Li, Jiawei Xu, João C. A. Oliveira, Alexej Scheremetjew, Lutz Ackermann
Published in: ACS Catalysis, Issue 14, 2024, Page(s) 8160-8167, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c01886

Well‐Defined Highly‐Coordinated Copper(III) Iodide and Pincer Tris(trifluoromethyl)copper Complexes

Author(s): Vladimir Motornov, Lutz Ackermann
Published in: Chemistry – A European Journal, 2024, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202401791

Palladium-Catalyzed Electrooxidative Double C–H Arylation

Author(s): Zhipeng Lin, João C. A. Oliveira, Alexej Scheremetjew, Lutz Ackermann
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 228-239, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c08479