Targeted strategies for prevention and treatment of fibrosis-associated liver cancer

Project Information

FIBCAN

Grant agreement ID: 101021417

DOI

10.3030/101021417

EC signature date 27 September 2021

Start date 1 July 2022

End date 30 June 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 430 000,00

EU contribution

€ 2 430 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions

Author(s): Chenyue Lu, Amaya Pankaj, Michael Raabe, Cole Nawrocki, Ann Liu, Nova Xu, Bidish K. Patel, Matthew J. Emmett, Avril K. Coley, Cristina R. Ferrone, Vikram Deshpande, Irun Bhan, Yujin Hoshida, David T. Ting, Martin J. Aryee, Joseph W. Franses
Published in: Hepatology Communications, Issue 8, 2024, ISSN 2471-254X
Publisher: Wolters Kluwer Health/LWW
DOI: 10.1097/hc9.0000000000000533

Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making

Author(s): Renumathy Dhanasekaran, Hiroyuki Suzuki, Lea Lemaitre, Naoto Kubota, Yujin Hoshida
Published in: Hepatology, 2024, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000513

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment

Author(s): Natascha Roehlen, Marion Muller, Zeina Nehme, Emilie Crouchet, Frank Jühling, Fabio del Zompo, Sara Cherradi, François Ht Duong, Nuno Almeida, Antonio Saviano, Mirian Fernández-Vaquero, Tobias Riedl, Houssein El Saghire, Sarah C Durand, Clara Ponsolles, Marine A Oudot, Romain Martin, Nicolas Brignon, Emanuele Felli, Patrick Pessaux, Antonin Lallement, Irwin Davidson, Simonetta Bandiera, Christi
Published in: Journal of Hepatology, Issue 78, 2023, Page(s) 343–355, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.011

Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic

Author(s): Hiroyuki Suzuki, Naoto Fujiwara, Amit G. Singal, Thomas F. Baumert, Raymond T. Chung, Takumi Kawaguchi, Yujin Hoshida
Published in: Hepatology, 2025, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000001227

STIE: Single-cell level deconvolution, convolution, and clustering in in situ capturing-based spatial transcriptomics

Author(s): Shijia Zhu, Naoto Kubota, Shidan Wang, Tao Wang, Guanghua Xiao, Yujin Hoshida
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51728-5

Tight Junction Protein Signaling and Cancer Biology

Author(s): Zeina Nehme; Natascha Roehlen; Punita Dhawan; Thomas F. Baumert
Published in: Cells, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12020243

Risk stratification and early detection biomarkers for precision HCC screening

Author(s): Yi‐Te Lee, Naoto Fujiwara, Ju Dong Yang, Yujin Hoshida
Published in: Hepatology, Issue 78, 2024, Page(s) 319-362, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.32779

Cost-effectiveness of a precision hepatocellular carcinoma surveillance strategy in patients with cirrhosis

Author(s): Szu-Yu Zoe Kao, Kinpritma Sangha, Naoto Fujiwara, Yujin Hoshida, Neehar D. Parikh, Amit G. Singal
Published in: eClinicalMedicine, Issue 75, 2024, Page(s) 102755, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1016/j.eclinm.2024.102755

Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images

Author(s): Zhuoyu Wen, Yu-Hsuan Lin, Shidan Wang, Naoto Fujiwara, Ruichen Rong, Kevin W. Jin, Donghan M. Yang, Bo Yao, Shengjie Yang, Tao Wang, Yang Xie, Yujin Hoshida, Hao Zhu, Guanghua Xiao
Published in: Genes, Issue 14, 2023, Page(s) 921, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14040921

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Author(s): Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne, Nevena Slovic, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Ming-Lun Yeh, Hiromi Abe-Chayama, Mathias Heikenwälder, Angelo Sangiovanni, Mas
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51698-8

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Author(s): Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos,
Published in: Science Translational Medicine, Issue 14, 2022, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abj4221

The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial

Author(s): David Hsiehchen, Muhammad S. Beg, Radhika Kainthla, Jay Lohrey, Syed M. Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K. Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A. Brekken, Chul Ahn, Amit G. Singal, Hao Zhu, Yujin Hoshida, Adam C. Yopp
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-46542-y

Targeting the liver clock improves fibrosis by restoring TGF-β signaling

Author(s): Emilie Crouchet, Mayssa Dachraoui, Frank Jühling, Natascha Roehlen, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Cloé Gadenne, Laura Meiss-Heydmann, Julien Moehlin, Romain Martin, Nicolas Brignon, Fabio Del Zompo, Yuji Teraoka, Hiroshi Aikata, Hiromi Abe-Chayama, Kazuaki Chayama, Antonio Saviano, Danijela Heide, Mihaela Onea, Lucas Geyer, Thibaut Wolf, Emanuele Felli, Patrick Pessaux, Math
Published in: Journal of Hepatology, Issue 82, 2024, Page(s) 120-133, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2024.07.034

Phase 3 Validation of PAaM for Hepatocellular Carcinoma Risk Stratification in Cirrhosis

Author(s): Naoto Fujiwara, Camden Lopez, Tracey L. Marsh, Indu Raman, Cesia A. Marquez, Subhojit Paul, Sumit K. Mishra, Naoto Kubota, Courtney Katz, Hiroaki Kanzaki, Michael Gonzalez, Lisa Quirk, Sneha Deodhar, Pratibha Selvakumar, Prithvi Raj, Neehar D. Parikh, Lewis R. Roberts, Myron E. Schwartz, Mindie H. Nguyen, Alex S. Befeler, Stephanie Page-Lester, Sudhir Srivastava, Ziding Feng, K. Rajender Reddy, Sa
Published in: Gastroenterology, 2025, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2024.10.035

The Search for Risk, Diagnostic, and Prognostic Biomarkers of Cholangiocarcinoma and Their Biological and Clinicopathologic Significance

Author(s): Rocio I.R. Macias, Hiroaki Kanzaki, Carmen Berasain, Matias A. Avila, Jose J.G. Marin, Yujin Hoshida
Published in: The American Journal of Pathology, 2025, ISSN 0002-9440
Publisher: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2024.06.013

Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation

Author(s): Emilie Crouchet, Shen Li, Mozhdeh Sojoodi, Simonetta Bandiera, Naoto Fujiwara, Hussein El Saghire, Shijia Zhu, Tongqi Qian, Fahmida Akter Rasha, Fabio Del Zompo, Stephen C. Barrett, Eugénie Schaeffer, Marine A. Oudot, Clara Ponsolles, Sarah C. Durand, Sarani Ghoshal, Gunisha Arora, Fabio Giannone, Raymond T. Chung, Nevena Slovic, Nicolaas Van Renne, Emanuele Felli, Patrick Pessaux, Joachim Lupber
Published in: JCI Insight, Issue 7, 2022, ISSN 2379-3708
Publisher: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.159254

Molecular and immune landscape of hepatocellular carcinoma for therapeutic development

Author(s): Hiroyuki Suzuki, Sumit Mishra, Subhojit Paul, Yujin Hoshida
Published in: Journal of Liver Cancer, 2024, ISSN 2288-8128
Publisher: The Korean Liver Cancer Association
DOI: 10.17998/jlc.2024.12.02

Transcriptomic signature in advanced hepatocellular carcinoma tissue to predict combination immunotherapy response: Editorial on “Genomic biomarkers to predict response to atezolizumab plus bevacizumab immunotherapy in hepatocellular carcinoma: Insights from the IMbrave150 trial”

Author(s): Hiroaki Kanzaki, Yujin Hoshida
Published in: Clinical and Molecular Hepatology, Issue 31, 2025, Page(s) 308-310, ISSN 2287-2728
Publisher: Korean Association for the Study of the Liver
DOI: 10.3350/cmh.2024.0726

Matrisomic characterization of HCC to inform individualized patient management

Author(s): Hiroaki Kanzaki, Courtney Katz, Yujin Hoshida
Published in: Hepatology, Issue 78, 2024, Page(s) 691-693, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000443

Intellectual Property Rights

Patent (4)

MOLECULAR SIGNATURES TO PREDICT LONG-TERM LIVER FIBROSIS PROGRESSION

Application/Publication number: 20 23079339
Date: 2023-11-10
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

MOLECULAR SIGNATURES OF LONG-TERM HEPATOCELLULAR CARCINOMA RISK IN NON-ALCOHOLIC FATTY LIVER DISEASE

Application/Publication number: 20 24035118
Date: 2024-06-21
Applicant(s): THE UNIVERSITY OF TEXAS SYSTEM

MOLECULAR SIGNATURES TO PREDICT LONG-TERM LIVER FIBROSIS PROGRESSION

Application/Publication number: 20 23079339
Date: 2023-11-10
Applicant(s): THE UNIVERSITY OF TEXAS SYSTEM

MOLECULAR SIGNATURES OF LONG-TERM HEPATOCELLULAR CARCINOMA RISK IN NON-ALCOHOLIC FATTY LIVER DISEASE

Application/Publication number: 20 24035118
Date: 2024-06-21
Applicant(s): INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE