Targeted strategies for prevention and treatment of fibrosis-associated liver cancer

Informazioni relative al progetto

FIBCAN

ID dell’accordo di sovvenzione: 101021417

DOI

10.3030/101021417

Data della firma CE 27 Settembre 2021

Data di avvio 1 Luglio 2022

Data di completamento 30 Giugno 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 430 000,00

Contributo UE

€ 2 430 000,00

Coordinato da

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

HCC spatial transcriptomic profiling reveals significant and potentially targetable cancer-endothelial interactions

Autori: Chenyue Lu, Amaya Pankaj, Michael Raabe, Cole Nawrocki, Ann Liu, Nova Xu, Bidish K. Patel, Matthew J. Emmett, Avril K. Coley, Cristina R. Ferrone, Vikram Deshpande, Irun Bhan, Yujin Hoshida, David T. Ting, Martin J. Aryee, Joseph W. Franses
Pubblicato in: Hepatology Communications, Numero 8, 2024, ISSN 2471-254X
Editore: Wolters Kluwer Health/LWW
DOI: 10.1097/hc9.0000000000000533

Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision-making

Autori: Renumathy Dhanasekaran, Hiroyuki Suzuki, Lea Lemaitre, Naoto Kubota, Yujin Hoshida
Pubblicato in: Hepatology, 2024, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000513

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment

Autori: Natascha Roehlen, Marion Muller, Zeina Nehme, Emilie Crouchet, Frank Jühling, Fabio del Zompo, Sara Cherradi, François Ht Duong, Nuno Almeida, Antonio Saviano, Mirian Fernández-Vaquero, Tobias Riedl, Houssein El Saghire, Sarah C Durand, Clara Ponsolles, Marine A Oudot, Romain Martin, Nicolas Brignon, Emanuele Felli, Patrick Pessaux, Antonin Lallement, Irwin Davidson, Simonetta Bandiera, Christi
Pubblicato in: Journal of Hepatology, Numero 78, 2023, Pagina/e 343–355, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2022.10.011

Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic

Autori: Hiroyuki Suzuki, Naoto Fujiwara, Amit G. Singal, Thomas F. Baumert, Raymond T. Chung, Takumi Kawaguchi, Yujin Hoshida
Pubblicato in: Hepatology, 2025, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000001227

STIE: Single-cell level deconvolution, convolution, and clustering in in situ capturing-based spatial transcriptomics

Autori: Shijia Zhu, Naoto Kubota, Shidan Wang, Tao Wang, Guanghua Xiao, Yujin Hoshida
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51728-5

Tight Junction Protein Signaling and Cancer Biology

Autori: Zeina Nehme; Natascha Roehlen; Punita Dhawan; Thomas F. Baumert
Pubblicato in: Cells, 2023, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12020243

Risk stratification and early detection biomarkers for precision HCC screening

Autori: Yi‐Te Lee, Naoto Fujiwara, Ju Dong Yang, Yujin Hoshida
Pubblicato in: Hepatology, Numero 78, 2024, Pagina/e 319-362, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.32779

Cost-effectiveness of a precision hepatocellular carcinoma surveillance strategy in patients with cirrhosis

Autori: Szu-Yu Zoe Kao, Kinpritma Sangha, Naoto Fujiwara, Yujin Hoshida, Neehar D. Parikh, Amit G. Singal
Pubblicato in: eClinicalMedicine, Numero 75, 2024, Pagina/e 102755, ISSN 2589-5370
Editore: Elsevier
DOI: 10.1016/j.eclinm.2024.102755

Deep-Learning-Based Hepatic Ploidy Quantification Using H&E Histopathology Images

Autori: Zhuoyu Wen, Yu-Hsuan Lin, Shidan Wang, Naoto Fujiwara, Ruichen Rong, Kevin W. Jin, Donghan M. Yang, Bo Yao, Shengjie Yang, Tao Wang, Yang Xie, Yujin Hoshida, Hao Zhu, Guanghua Xiao
Pubblicato in: Genes, Numero 14, 2023, Pagina/e 921, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14040921

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Autori: Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne, Nevena Slovic, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Ming-Lun Yeh, Hiromi Abe-Chayama, Mathias Heikenwälder, Angelo Sangiovanni, Mas
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51698-8

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Autori: Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos,
Pubblicato in: Science Translational Medicine, Numero 14, 2022, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abj4221

The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial

Autori: David Hsiehchen, Muhammad S. Beg, Radhika Kainthla, Jay Lohrey, Syed M. Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K. Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A. Brekken, Chul Ahn, Amit G. Singal, Hao Zhu, Yujin Hoshida, Adam C. Yopp
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-46542-y

Targeting the liver clock improves fibrosis by restoring TGF-β signaling

Autori: Emilie Crouchet, Mayssa Dachraoui, Frank Jühling, Natascha Roehlen, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Cloé Gadenne, Laura Meiss-Heydmann, Julien Moehlin, Romain Martin, Nicolas Brignon, Fabio Del Zompo, Yuji Teraoka, Hiroshi Aikata, Hiromi Abe-Chayama, Kazuaki Chayama, Antonio Saviano, Danijela Heide, Mihaela Onea, Lucas Geyer, Thibaut Wolf, Emanuele Felli, Patrick Pessaux, Math
Pubblicato in: Journal of Hepatology, Numero 82, 2024, Pagina/e 120-133, ISSN 0168-8278
Editore: Elsevier BV
DOI: 10.1016/j.jhep.2024.07.034

Phase 3 Validation of PAaM for Hepatocellular Carcinoma Risk Stratification in Cirrhosis

Autori: Naoto Fujiwara, Camden Lopez, Tracey L. Marsh, Indu Raman, Cesia A. Marquez, Subhojit Paul, Sumit K. Mishra, Naoto Kubota, Courtney Katz, Hiroaki Kanzaki, Michael Gonzalez, Lisa Quirk, Sneha Deodhar, Pratibha Selvakumar, Prithvi Raj, Neehar D. Parikh, Lewis R. Roberts, Myron E. Schwartz, Mindie H. Nguyen, Alex S. Befeler, Stephanie Page-Lester, Sudhir Srivastava, Ziding Feng, K. Rajender Reddy, Sa
Pubblicato in: Gastroenterology, 2025, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2024.10.035

The Search for Risk, Diagnostic, and Prognostic Biomarkers of Cholangiocarcinoma and Their Biological and Clinicopathologic Significance

Autori: Rocio I.R. Macias, Hiroaki Kanzaki, Carmen Berasain, Matias A. Avila, Jose J.G. Marin, Yujin Hoshida
Pubblicato in: The American Journal of Pathology, 2025, ISSN 0002-9440
Editore: American Society for Investigative Pathology
DOI: 10.1016/j.ajpath.2024.06.013

Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation

Autori: Emilie Crouchet, Shen Li, Mozhdeh Sojoodi, Simonetta Bandiera, Naoto Fujiwara, Hussein El Saghire, Shijia Zhu, Tongqi Qian, Fahmida Akter Rasha, Fabio Del Zompo, Stephen C. Barrett, Eugénie Schaeffer, Marine A. Oudot, Clara Ponsolles, Sarah C. Durand, Sarani Ghoshal, Gunisha Arora, Fabio Giannone, Raymond T. Chung, Nevena Slovic, Nicolaas Van Renne, Emanuele Felli, Patrick Pessaux, Joachim Lupber
Pubblicato in: JCI Insight, Numero 7, 2022, ISSN 2379-3708
Editore: American Society for Clinical Investigation (ASCI)
DOI: 10.1172/jci.insight.159254

Molecular and immune landscape of hepatocellular carcinoma for therapeutic development

Autori: Hiroyuki Suzuki, Sumit Mishra, Subhojit Paul, Yujin Hoshida
Pubblicato in: Journal of Liver Cancer, 2024, ISSN 2288-8128
Editore: The Korean Liver Cancer Association
DOI: 10.17998/jlc.2024.12.02

Transcriptomic signature in advanced hepatocellular carcinoma tissue to predict combination immunotherapy response: Editorial on “Genomic biomarkers to predict response to atezolizumab plus bevacizumab immunotherapy in hepatocellular carcinoma: Insights from the IMbrave150 trial”

Autori: Hiroaki Kanzaki, Yujin Hoshida
Pubblicato in: Clinical and Molecular Hepatology, Numero 31, 2025, Pagina/e 308-310, ISSN 2287-2728
Editore: Korean Association for the Study of the Liver
DOI: 10.3350/cmh.2024.0726

Matrisomic characterization of HCC to inform individualized patient management

Autori: Hiroaki Kanzaki, Courtney Katz, Yujin Hoshida
Pubblicato in: Hepatology, Numero 78, 2024, Pagina/e 691-693, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000443

Diritti di proprietà intellettuale

Patent (4)

MOLECULAR SIGNATURES TO PREDICT LONG-TERM LIVER FIBROSIS PROGRESSION

Numero candidatura/pubblicazione: 20 23079339
Data: 2023-11-10
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

MOLECULAR SIGNATURES OF LONG-TERM HEPATOCELLULAR CARCINOMA RISK IN NON-ALCOHOLIC FATTY LIVER DISEASE

Numero candidatura/pubblicazione: 20 24035118
Data: 2024-06-21
Candidato/i: THE UNIVERSITY OF TEXAS SYSTEM

MOLECULAR SIGNATURES TO PREDICT LONG-TERM LIVER FIBROSIS PROGRESSION

Numero candidatura/pubblicazione: 20 23079339
Data: 2023-11-10
Candidato/i: THE UNIVERSITY OF TEXAS SYSTEM

MOLECULAR SIGNATURES OF LONG-TERM HEPATOCELLULAR CARCINOMA RISK IN NON-ALCOHOLIC FATTY LIVER DISEASE

Numero candidatura/pubblicazione: 20 24035118
Data: 2024-06-21
Candidato/i: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE