Projektbeschreibung
Entwicklung chiraler pharmakologischer Moleküle durch kombinierte elektrochemische und organische Katalyse
In der Wirkstoffforschung wird an neuen Arzneimittelkandidaten geforscht. Katalytische Prozesse zur Erzeugung chiraler Moleküle (die durch Ebenenspiegelung nicht zur Selbstabbildung gelangen) sind hier außerordentlich nützliche Werkzeuge. Das über die Marie-Skłodowska-Curie-Maßnahmen finanzierte Projekt ELECTROORGANO kombiniert asymmetrische Organokatalyse und mikrofluidische Elektrochemie für die Aktivierung von Molekülen, um Chiralität zu erzeugen. Durch Kombination beider Verfahren sollen über bisherige technische Hürden hinaus chirale Bausteine mit hoher Stereoselektivität erzeugt werden. Zudem werden mechanistische Untersuchungen Grundlagenwissen zur enantioselektiven Induktion liefern und künftige Durchbrüche in der enantioselektiven Elektrochemie befördern.
Ziel
Drug discovery must identify successful lead candidates. As such, the development of new catalytic methods for the production of chiral molecules is extremely valuable. ELECTRORGANO seeks to synergistically combine two powerful modes of molecule activation, namely asymmetric organocatalysis and microfluidic electrochemistry, to provide an attractive new pathway for the formation of demanded chiral molecules. Both organocatalysis and electrochemistry possess extraordinary potential for the sustainable preparation of novel organic molecules, which are required to drive innovation within the pharmaceutical industry. However, the implementation of electrochemical methods for the design of stereoselective processes is still falling short, mostly due to the fleetingness of the radical ions intermediates generated on the electrode surface. ELECTRORGANO asks whether the use of an electrochemical microfluidic setup, coupled with asymmetric organocatalysis, can overcome these intrinsic limitations, rapidly providing chiral building blocks with high stereocontrol. Finally, mechanistic studies, aided by the use of in-line instruments, will provide fundamental understanding in the origin of the enantioselective induction, setting the stage for future breakthroughs in enantioselective electrochemistry.
This project is highly interdisciplinary, involving different research areas such as asymmetric organocatalysis, electrochemistry, and microfluidics. As such, it is envisioned that the development of this new platform can generate breakthrough scientific papers, valuable discoveries and/or potential patents. This fellowship brings a two-fold transfer of knowledge: advanced techniques in asymmetric catalysis to the host institution and electrochemical methods and microfluidic flow chemistry to the fellow. Overall, the project’s multidisciplinarity and intersectoral nature will broaden the fellow’s competencies and will place him in a competitive position for his next career move.
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