Project description
Algorithms development for image-guided proton therapy
Proton therapy (PT) is a new type of radiation therapy that allows better control and targeting of the proton beams, resulting in fewer side effects than traditional radiation. It is well suited for the treatment of non-small cell lung cancer, but the expected benefits of PT are significantly obstructed by patients’ breathing motion. The goal of the EU-funded MSPrad project is to develop real-time tumour tracking for accurate PT treatment. The objectives encompass development of a proton radiography image quality enhancement algorithm, implementation of a position tracking algorithm from high-quality proton radiography, and comprehensive experimental validation of the integrated image-guided PT unit.
Objective
Proton therapy is a new radiotherapy modality which aims to maximize dose deposition in tumors, while sparing surrounding healthy tissues. It is uniquely suited for the treatment of non-small cell lung cancer, a deadly cancer of current unmet needs. Improving the prognosis of non-small cell lung cancer is an important health and wellbeing milestone, which was identified as one of Europe’s societal challenge in the Horizon 2020 programme. However, the expected benefits of proton therapy are largely impaired by patient motion (breathing) during treatment. A potential solution is to adapt the treatment in real-time by following the location of the tumour with imaging.
The overreaching goal of this action is to enable real-time tumor tracking for accurate lung tumor treatment in proton radiotherapy. To do so, a radiographic device, developed by the prospective group, will use the proton treatment source to generate quasi real-time images (proton radiographs) to mitigate the impact of breathing on treatment quality. However, due to the poor image quality of current radiographs, rapid image quality optimization algorithms are mandatory to allow real-time adaptation.
This action focuses on producing the necessary algorithms and validation to use proton radiographs in real time. The three main objectives are to (1) develop a proton radiography image quality enhancement (resolution and noise) algorithm based on deconvolution, (2) implement a tumor position tracking algorithm from high-quality proton radiographies, and (3) perform a full experimental validation on the integrated image-guided proton therapy unit.
This work will be carried out at University College London (UCL) and its affiliated hospital (UCLH), under the supervision of Prof. Gary Royle and co-supervision of Dr. Charles-Antoine Collins Fekete. It will be a synergistic combination of the applicant’s experience in image reconstruction/analysis and UCL’s expertise on proton physics and therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC1E 6BT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.