Project description
Smart biomaterials for tissue bioprinting
3D printing is a process that produces physical objects from a digital model by laying down many successive thin layers of different materials. 3D printing has extended into tissue engineering for the fabrication of tissues from cells and other biomaterials. The EU-funded MagnetoPrint project aims to address existing technical challenges associated with bioprinting such as poor resolution, which prohibits the correct deposition and preservation of cells and biomaterials. Researchers will develop a novel approach that closely recapitulates the physiological conditions of the native tissue. The project is expected to advance the fabrication of biomimetic tissues.
Objective
3D printing (3DP) technology plays a pivotal role in the biofabrication of engineered tissues which are useful towards several clinical, diagnostic and research applications. Of the different 3DP approaches, extrusion bioprinting (EBp) is the most widely used, for it is cost effective and allows rapid fabrication of physiological scale tissues with controlled placement of different types of encapsulated cells and biomaterials. However, the poor resolution (> 200 µm) of most EBp approaches limits the topographical cues necessary to impart anisotropic cell (avg. ϕ = 20 µm) and extracellular matrix organization within the tissues. Moreover, most tissue engineering approaches do not meet the nutritional requirements of the cells within thick tissues, and utilize static cultures which do not recapitulate the physiological growth conditions. Due to these reasons, the engineered tissues fail to biomimic native tissue properties. The proposed MagnetoPrint process aims to achieve biomimicry via a synergy of chemistry, biology, electromechanical systems design, structural mechanics and multiphysics modeling. First, cell-laden hydrogels are synthesized which could be sized into microstrands (avg. ϕ = 40 µm) during printing, that could impart the relevant anisotropic characteristics. Second, ferromagnetic particles are incorporated within distinct compartments inside the hydrogels to facilitate the deformation of printed tissue in the presence of external magnetic fields. Control of the domain orientations of the magnetic particles is used to impart auxetic properties, to further support nutrient transport and tissue maturation, which is also verified by computational modeling. Third, a complex muscle/tendon interface is printed and matured under the relevant exercising conditions to demonstrate the effectiveness of the project. The process, with its unprecedented features, represents significant progress in the advanced scalable manufacturing of biomimetic engineered tissues.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- natural sciences computer and information sciences computational science multiphysics
- engineering and technology mechanical engineering manufacturing engineering additive manufacturing
- engineering and technology industrial biotechnology biomaterials
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.