Descripción del proyecto
Protección de la función renal en los cuidados intensivos
La lesión renal aguda (LRA) se define como el deterioro de la función renal en un período relativamente corto y es una complicación con elevada incidencia entre los pacientes hospitalizados en las unidades de cuidados intensivos (UCI). La hipótesis de trabajo del proyecto ELECTRIC, financiado con fondos europeos, es que la prevención de la LRA en los pacientes de UCI pasa por proteger la función renal. Por consiguiente, los investigadores del proyecto emplearán un modelo animal para probar dos nuevos agentes utilizados para proteger a los pacientes con diabetes de enfermedades renales crónicas. Medirán biomarcadores relacionados con la función renal y desarrollarán técnicas innovadoras que permitan realizar mediciones no invasivas de la fisiología renal en los pacientes.
Objetivo
On the intensive care unit, more than 50% of patients have acute kidney injury, and these patients suffer higher mortality and long-term morbidity. To date, no specific therapies exist to prevent or treat acute kidney injury on the intensive care unit. We now have two new endocrinologic agents, glucagon-like peptide-1 receptor agonists and sodium-glucose transport protein 2 inhibitors, able to protect patients with diabetes from chronic kidney disease. The objective of this action is to investigate whether the renoprotective mechanisms of these agents can reduce markers of acute kidney injury in patients on the intensive care unit. This action incorporates a highly sophisticated animal model for the essential invasive measurement of renal physiology. To translate these findings to the clinical situation, I will employ new and innovative measurement techniques such as urinary oxygenation, new kidney biomarkers and advanced renal imaging techniques to elucidate these renoprotective mechanisms in humans. The involved universities of Amsterdam and the University of Melbourne bring together world leading experts on acute kidney injury, endocrinologic therapies, and intensive care medicine. By connecting their expertise, this action will not only provide insight into the renoprotective properties of the studied interventions and so improve the outcome of patients, but also train me as a researcher able to improve renal outcomes beyond the scope of this action.
Ámbito científico
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Régimen de financiación
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
1081 HV Amsterdam
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