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Brain-based Evaluation of Autism Phenotypes Using Longitudinal, Multimodal Imaging Data

Project description

Neurobiological signatures to support autism management

Autism refers to a group of neurodevelopmental conditions associated with difficulties with social interaction and communication. Despite advances in brain characterisation research, there are no tools or biomarkers to date for predicting clinical outcomes in autism. To address this problem, the EU-funded BEAUTIPHUL MIND project will characterise individual neurobiological signatures in autism. Considering the great variation in autistic phenotypes, researchers will combine structural and functional neuroimaging data from different patients and compare each one to the expected pattern. Results have the potential to support tailor-made interventions for patients with autism and improve clinical management of the condition.

Objective

Methodological developments have equipped scientists with unprecedented opportunities to characterize brain structure and functional organization and relate it to behaviour. Yet to date, no clinically relevant tools, grounded in this neurobiology, have been developed that inform clinical outcomes in psychiatric disorders. Specifically, in autism – one of the most common neurodevelopmental conditions – there is still little knowledge about the neurobiological underpinnings of different clinical outcomes with regard to core symptoms and adaptive daily living skills. While some individuals worsen, others do better over time. Like in many realms of medicine where biomarkers have revolutionized treatment, there is also an urgent need to develop such neurobiologically-grounded predictors for clinical outcomes in autism. To date, the majority of studies have analysed small, cross-sectional samples across single neuroimaging modalities with case-control comparisons to find mean group effects. However, this standard approach ignores the large sample variation in autism. The overarching objective of my MSCA Fellowship is to establish a multimodal, longitudinal characterization of the individual neurobiological signatures that are predictive of clinical outcomes in autism. I will integrate both structural and functional neuroimaging modalities for a fine-grained characterization of the neural phenotypes in autism. Using normative modelling, I will characterize at the level of the individual (rather than with group averages) how each individual with autism is different from the neurotypical pattern of such a multimodal brain characterization and how it relates to behaviour, genetic risk and clinical outcome. This novel approach has the potential to transform clinical management in autism, leading to the development of neuroscientifically-informed, targeted interventions. I will also provide the research community with novel tools that pave the way for precision medicine.

Coordinator

UNIVERSITAT ZURICH
Net EU contribution
€ 191 149,44
Address
RAMISTRASSE 71
8006 Zurich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 191 149,44