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Identification of transcriptional memory maintenance factors through a cell selection strategy

Project description

Advanced study into the mechanisms of transcriptional memory

Transcriptional memory is a phenomenon during which cells primed with particular stimuli show increased gene expression after re-stimulation at a later time. Such memory of gene expression states is essential for the development and maintenance of tissues. Funded by the Marie Skłodowska-Curie Actions programme, the IMMUNE-GENEMEMO project is based on the discovery of genes with a strong transcriptional memory of prior interferon-gamma (IFNγ) activation, creating a larger proportion of cells expressing the target gene. The project aims to identify novel transcriptional memory maintenance factors in human cells using an efficient high-throughput cell sorting strategy combined with genome-wide CRISPR-Cas9 mutagenesis protocols, and establish the role of these components in the stability of dendritic cell identity.

Coordinator

UNIWERSYTET GDANSKI
Net EU contribution
€ 252 078,72
Address
Ul. Bazynskiego 8
80309 Gdansk
Poland

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Region
Makroregion północny Pomorskie Trójmiejski
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE GENERAL HOSPITAL CORPORATION
United States
Net EU contribution
€ 0,00
Non-EU contribution
€ 177 265,92