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Evolution of human tooth enamel: unlocking hidden cell mechanisms

Project description

Teeth tell us a lot about the genus Homo

Despite decades of research, scientists still struggle to distinguish the fossils of our genus, Homo, from primate relatives. Also, relations between different members of our genus Homo remain unclear. Since teeth remain well preserved in fossils, the tooth’s enamel thickness emerges as a promising indication for taxonomic classification. But so far, there is little knowledge about cell processes generating differences in enamel thickness. In this context, the EU-funded DENTALkeys project will identify the links between enamel growth and density through interdisciplinary study. It will combine 3D and 2D microtomography, histology and theoretical biology to uncover new traits in our fossil ancestors while enabling classification and better knowledge of human evolution.

Objective

Understanding the ways in which we relate to our fossil ancestors is fundamental to elucidating how modern humans evolved. Yet, after a century of investigations, there is still no consensus about relationships among some members of the genus Homo. Studies of enamel thickness have been at the centre of these debates. Teeth preserve well in the fossil record and enamel thickness is a trait that can contribute to taxonomic classification. Yet, we know very little about the cell mechanisms that generate variation in enamel thickness. Several of our fossil ancestors have enamel that is of similar thickness, though it formed with very different underlying developmental processes. The goal in this interdisciplinary project is to combine 3D and 2D microtomography, histology, and theoretical biology to identify links between enamel growth and thickness to reveal novel traits in our fossil ancestors that will contribute new classification knowledge to our understanding of human evolution. I will examine modern day samples and fossil samples spanning the past 2 million years from the genus Homo. I will use the knowledge I gain to re-examine existing debates about which fossils are, or are not, ‘human-like’ to provide novel insights into their classification. Results will be of interest to anthropologists, human biologists, archaeologists, as well as the general public. My project will provide novel information about human growth and development that will also be of interest to clinicians.

Coordinator

UNIVERSITY OF KENT
Net EU contribution
€ 224 933,76
Address
THE REGISTRY CANTERBURY
CT2 7NZ Canterbury, Kent
United Kingdom

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Region
South East (England) Kent East Kent
Activity type
Higher or Secondary Education Establishments
Links
Total cost
€ 224 933,76