High Resolution, Reduced Energy Flexible Electronics for Enhanced Brain-Spine Interfaces (REFLEX)

Projektinformationen

REFLEX

ID Finanzhilfevereinbarung: 101027005

DOI 10.3030/101027005

Das Projekt endete am 31 März 2023

EK-Unterschriftsdatum 23 März 2021

Startdatum 1 Juni 2021

Enddatum 16 Juni 2023

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 191 149,44

EU-Beitrag € 191 149,44

Koordiniert durch

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Projektbeschreibung

Hirn-Wirbelsäulen-Schnittstellen mittels innovativer elektronischer Medizintechnik

Bioelektronische Medizintechnik wie Hirn-Wirbelsäulen-Schnittstellen können die Behandlung sensomotorischer und kognitiver Störungen unterstützen. Welche biologischen und elektrophysiologischen Parameter für eine Behandlung wichtig sind, ist allerdings noch unklar. Das EU-finanzierte Projekt REFLEX soll die Stromversorgung und Ummantelung der Schnittstellen technisch optimieren und die Kontrolle neuronaler Signalwege in Echtzeit ermöglichen. Verwendet werden hierfür innovative Technologien, etwa die Pikojoule/Bit-Energieeffizienz bei der Rückstreuung von Funkwellen, sowie anpassungsfähige, kompatible Leiterplatten. In hoher räumlich-zeitlicher Auflösung sollen neuronale Signalwege überwacht werden, um zu testen, inwieweit zielgerichtete Therapien zur Regeneration geschädigter Nervenbahnen im Rückenmark beitragen können.

Ziel

Emerging bioelectronic medical devices, such as brain-spine interfaces (BSI), are improving treatments of the pathophysiological processes at the root of sensorimotor and cognitive disorders. Despite the emerging success of BSIs, the biological and electrophysiological mechanisms underlying treatments remain poorly understood. A significant barrier to their description is the lack of minimally invasive BSIs for real-time, closed-loop monitoring of electrophysiological markers involved in the stabilization and regeneration of neural pathways. REFLEX seeks to overcome the power and packaging barriers that have held back real-time monitoring of neural pathways by leveraging two innovative technologies: (1) the picojoule/bit energy efficiency of wireless backscatter communication and (2) the conformable, compatible circuit boards. REFLEX will enable high spatial and temporal resolution monitoring of neural pathways by providing up to 16 channels for electrophysiological recording at up to 20 kSamples/sec with 16-bit resolution per channel (≥5Mbps total data rate) at <2 mW of total power consumption for recording. By incorporating a low power LED for optogenetic stimulation of neurons, REFLEX will test the effectiveness of targeted therapies to regenerate damaged neural pathways in the spinal cord. The proposed project aligns with the MSCA mission by facilitating the two-way transfer of knowledge in material science, electrical engineering, and neuroscience between the host and the applicant. It combines the applicant’s expertise in wireless backscatter communications and electronic instrumentation with the host laboratory’s expertise in conformable electrode design and interdisciplinary breakthroughs in implantable systems. Through hands-on research, formal training, and new collaborations, the applicant will enhance his research expertise, broaden his professional skill sets, and mature his competencies as a mobile researcher, engineer, and educator.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• social sciences › educational sciences › didactics
• engineering and technology › electrical engineering, electronic engineering, information engineering › electrical engineering
• engineering and technology › electrical engineering, electronic engineering, information engineering › information engineering › telecommunications › radio technology

Schlüsselbegriffe

• Backscatter communication
• RFID
• neural recording

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2020 - Individual Fellowships

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2020

Finanzierungsplan

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Koordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

• Netto-EU-Beitrag: € 191 149,44
• Adresse: BATIMENT CE 3316 STATION 1 ; 1015 Lausanne ; Schweiz
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 191 149,44