Molecular players of cancer metastasis
Cancer cells have the remarkable ability to travel through the blood stream or the lymphatic system to distant tissues and cause metastases. Clusters of circulating tumour cells (CTCs) are usually responsible for metastasis formation, but little is known on how their size impacts their metastatic potential. The EU-funded RYTAC project will investigate the dynamics of CTC clusters and especially the role of the YAP and TAZ proteins, transcriptional coactivators with opposing roles in various cellular functions. Researchers will delineate the localisation of these proteins in CTC clusters and its association with metastatic lesions. Project findings will have a significant impact on the clinical management of cancer and the design of targeted treatments.
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