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In vivo fuel utilization and metabolic regulation by brown adipose tissue

Project description

A deeper look into glucose metabolism in brown adipose tissue during thermogenesis

Brown adipose tissue (BAT) dissipates chemical energy generated from glucose and lipids as heat in the course of the thermogenesis process, which is induced by exposure to cold. This process has attracted clinical interest as a strategy against obesity and diabetes, as a way to expend excess calories as heat. The EU-funded GLUCOBAT project aims to comprehensively define how BAT utilises key fuels such as glucose in vivo. The research will involve mass spectrometry combined with Cre–Lox and novel CRISPR/Cas9 genome-editing strategies to identify how thermogenic tissue utilises glucose as well as the role the solute carrier transporters of the SCL family play in glucose utilisation and thermogenesis.

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution
€ 286 921,92
Address
Norregade 10
1165 Kobenhavn
Denmark

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITY OF MASSACHUSETTS
United States
Net EU contribution
€ 0,00
Address
Butterfield Terrace 70
01003 Amherst

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 177 265,92