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Fighting the X. fastidiosa threat to EU agriculture - Novel smart biopesticides based on bacterial spores

Descripción del proyecto

Desarrollo de un bioplaguicida a base de esporas para combatir la amenaza de «Xylella fastidiosa»

El fitopatógeno «Xylella fastidiosa», una especie invasora y muy destructiva, amenaza los olivares, así como otras plantas y frutales. Con todo, hoy día no se dispone de ningún tratamiento de campo para proteger las especies vegetales de cultivo contra esta amenaza. El proyecto SMART-AGRI-SPORE, financiado con fondos europeos, ayudará a combatir este patógeno al desarrollar un novedoso bioplaguicida inteligente basado en esporas bacterianas, que actúa de manera específica contra «X. fastidiosa» en árboles e insectos vectores infectados. Los investigadores diseñarán esporas del género «Bacillus» para que actúen como un vehículo de distribución de bioplaguicidas, lo que constituye toda una primicia en un entorno agrícola. Se analizarán las esporas para descubrir péptidos antimicrobianos novedosos que actúen de manera específica y eficaz contra «X. fastidiosa» y, a continuación, se diseñarán para expresar y almacenar estos agentes activos en el núcleo o la cubierta antes de ser liberados al medio ambiente.

Objetivo

EU agriculture is facing an unparalleled threat by the pest Xylella fastidiosa, potentially causing an annual production loss of ‎5.5 billion euros and putting at risk 300.000 jobs if its expansion cannot be contained. Hence, the eradication of this bacterium remains a key priority of the EU. Yet, no field treatment is currently available, highlighting the dire need for effective pesticides against this menace.
At the same time the European Commission’s ambitious Green Deal and its Farm to Fork strategy set the reduction by 50% of the use of chemical pesticides by 2030 as a key priority. However, today, the availability of biological alternatives is limited and novel solutions targeting the most detrimental pests are urgently needed.
In light of these challenges, we propose the development of a novel, smart biopesticide based on bacterial spores (SMART-AGRI-SPORE), specifically targeting X. fastidiosa in infected trees and insect vectors.
Although the use of spores in medical applications is well established, here we extend the concept for the first time to an agricultural use by engineering spores as a biopesticide delivery vehicle.
To do so, Bacillus candidates will be isolated from orchards and vectors, while an activity screen will identify novel antimicrobial peptides efficiently targeting X. fastidiosa. Spores will be engineered to express and store these active agents in the core or coat, shielding them from physicochemical and biological degradation through the protective spore structure. Using an innovative design approach, the heterologous protein will be released into the environment during induced autolytic germination.
This study will provide novel insights into the treatment of X. fastidiosa under field conditions, while also extending our repertoire of alternative biopesticides for use in EU agriculture. In a wider context the project seeks to contribute to transforming EU agriculture into a modern, resource-efficient and resilient sector.

Coordinador

UNIVERSIDAD DE JAEN
Aportación neta de la UEn
€ 259 398,72
Dirección
CAMPUS LAS LAGUNILLAS SN EDIFICO B1 VICERRECTORADO DE INVESTIGACION DESAR TECN E INNOVACION
23071 Jaen
España

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Región
Sur Andalucía Jaén
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 259 398,72