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Fighting the X. fastidiosa threat to EU agriculture - Novel smart biopesticides based on bacterial spores

Descrizione del progetto

Biopesticida a base di spore sviluppato per combattere la minaccia della Xylella fastidiosa

Gli uliveti e altre piante e frutti sono a rischio a causa della Xylella fastidiosa, un patogeno vegetale invasivo altamente distruttivo. Tuttavia, attualmente non è disponibile alcun trattamento sul campo per proteggere le colture da questa minaccia. Il progetto SMART-AGRI-SPORE, finanziato dall’UE, contribuirà a combattere l’agente patogeno sviluppando un nuovo biopesticida intelligente basato su spore batteriche, che si rivolge specificamente alla X. fastidiosa negli alberi infetti e nei vettori di insetti. Per la prima volta in un ambiente agricolo, i ricercatori progetteranno le spore di Bacillus affinché fungano da veicolo di consegna di biopesticidi. Le spore saranno esaminate per nuovi peptidi antimicrobici mirati in modo efficiente alla X. fastidiosa e progettate per esprimere e immagazzinare questi agenti attivi nel nucleo o nel rivestimento prima di essere rilasciati nell’ambiente.

Obiettivo

EU agriculture is facing an unparalleled threat by the pest Xylella fastidiosa, potentially causing an annual production loss of ‎5.5 billion euros and putting at risk 300.000 jobs if its expansion cannot be contained. Hence, the eradication of this bacterium remains a key priority of the EU. Yet, no field treatment is currently available, highlighting the dire need for effective pesticides against this menace.
At the same time the European Commission’s ambitious Green Deal and its Farm to Fork strategy set the reduction by 50% of the use of chemical pesticides by 2030 as a key priority. However, today, the availability of biological alternatives is limited and novel solutions targeting the most detrimental pests are urgently needed.
In light of these challenges, we propose the development of a novel, smart biopesticide based on bacterial spores (SMART-AGRI-SPORE), specifically targeting X. fastidiosa in infected trees and insect vectors.
Although the use of spores in medical applications is well established, here we extend the concept for the first time to an agricultural use by engineering spores as a biopesticide delivery vehicle.
To do so, Bacillus candidates will be isolated from orchards and vectors, while an activity screen will identify novel antimicrobial peptides efficiently targeting X. fastidiosa. Spores will be engineered to express and store these active agents in the core or coat, shielding them from physicochemical and biological degradation through the protective spore structure. Using an innovative design approach, the heterologous protein will be released into the environment during induced autolytic germination.
This study will provide novel insights into the treatment of X. fastidiosa under field conditions, while also extending our repertoire of alternative biopesticides for use in EU agriculture. In a wider context the project seeks to contribute to transforming EU agriculture into a modern, resource-efficient and resilient sector.

Coordinatore

UNIVERSIDAD DE JAEN
Contribution nette de l'UE
€ 259 398,72
Indirizzo
CAMPUS LAS LAGUNILLAS SN EDIFICO B1 VICERRECTORADO DE INVESTIGACION DESAR TECN E INNOVACION
23071 Jaen
Spagna

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Regione
Sur Andalucía Jaén
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 259 398,72