Periodic Reporting for period 2 - HYPOVACC (Hydrogel/Polymersome-based Subunit Vaccines in the Fight Against COVID-19)
Periodo di rendicontazione: 2023-06-01 al 2024-05-31
The development of effective vaccine technologies for the fight against severe infectious diseases has been one of the most successful global health interventions in history. Yet, the threat of future and ongoing pandemics arisen from viruses such as the SARS-CoV-2 virus complexifies the design of readily applicable vaccine formulations. Over the last three years, the COVID-19 pandemic has quickly evolved with the emergence of multiple variants, including the immune evasive variant Omicron that can escape the immune response and participates in reducing vaccine effectiveness. To face the overall challenges of the pandemic, Moderna and Pfizer-BioNTech mRNA vaccines have been authorized for emergency use. While this technology is revolutionary, it suffers from strict storage conditions as well as lack of protection over long timescales and against variants, which lead to burdensome vaccination schedules as well as expensive manufacturing and distribution. There is therefore a need for more protective, potent, and easily manufacturable vaccines to enhance immunity and decrease the burden of patient compliance.
The project HYPOVACC aims to overcome these issues by designing cost-effective vaccine systems able to effectively protect against a variety of viruses belonging to the family of coronaviruses such as SARS-CoV-2 or potential future related viruses. These efforts envision to decrease the cost of manufacturing/distribution, and number of vaccinations, reinforcing therefore worldwide vaccine equity and patient compliance.
The project HYPOVACC aims to overcome these issues by designing cost-effective vaccine systems able to effectively protect against a variety of viruses belonging to the family of coronaviruses such as SARS-CoV-2 or potential future related viruses. These efforts envision to decrease the cost of manufacturing/distribution, and number of vaccinations, reinforcing therefore worldwide vaccine equity and patient compliance.
We successfully designed vaccine delivery systems able to significantly enhance the protection against the SARS-CoV-2 Omicron variant as well as other coronaviruses in a same vaccine formulation. Short-term and long-term protection over several months have been validated in rodents.
The HYPOVACC project outperforms the state of start through the design of potent vaccine delivery systems for enhancing the protection against current and future coronaviruses. More importantly, this newly designed vaccine formulation is easily formed with cost-effective and clinically approved materials, reinforcing its translation into the clinic. Moreover, this system can be easily modulated to be applied to a variety of challenging infectious diseases such as HIV, malaria, or flu, participating therefore in the reinforcement of Global Health research.