Descripción del proyecto
Nuevos biomateriales para la ingeniería de tejidos
Los policarbonatos alifáticos son compuestos que contienen el grupo químico -O-C(O)-O- en una estructura no aromática. En los últimos años, ha resurgido el interés por estas moléculas debido a los avances en su producción. Sus características atractivas incluyen la biocompatibilidad y la degradación sin ácidos, lo que hace que los policarbonatos alifáticos sean ideales para biomateriales, ya que no causan inflamación de los tejidos. Además, se pueden funcionalizar y, por lo tanto, servir como implantes y vehículos de administración de fármacos. El equipo del proyecto PhotoPolyCarb, financiado con fondos europeos, está trabajando en un método de impresión 3D que emplea policarbonatos alifáticos para desarrollar biomateriales que puedan ser utilizados en la ingeniería de tejidos. Este método representa un avance en el desarrollo de implantes personalizados, que podrían mejorar la salud y la calidad de vida de los pacientes.
Objetivo
Over the past years, aliphatic polycarbonates (APCs) have gained prominence in the biomedical field in reason of their features allied to their in vivo bioresorbability. Unlike polyesters, the degradation products of APCs are acid free, which prevents tissue inflammation and drug denaturation upon their use as implants and drug vehicles, making them a potential material in the medical field. Simultaneously, the 3D printing of biomaterials has recently advanced the development of tailor-made implants, which can improve the patients’ health and quality of life. However, the translative impact of 3D printing to clinical use is still beset with limitations, including the brittle nature of the properties of materials that are available, the crosslinking chemistries that hinder translation into cell-laden biomaterials and toxicity of residual monomers and additives. PhotoPolyCarb aims to overcome these limitations by combining functional photoreactive polycarbonates from different topographies with stereolithography (SLA), thus avoiding the use of toxic monomers and photoinitiators during the printing process. In a transfer of knowledge, PhotoPolyCarb will bring together the expertise of the researchers in areas such as chemical engineering reactions (from the applicant), polymer chemistry (from the host) and bioengineering (from the secondment). The fellowship will permit the applicant to work with world-renowned research groups in the field of biomaterials and tissue engineering, allowing her to develop skills in an interdisciplinary environment and consolidate her career. The dissemination of research results will target the professional audience as well the public through outreach activities.
Ámbito científico
- medical and health sciencesmedical biotechnologytissue engineering
- natural scienceschemical sciencespolymer sciences
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplants
Palabras clave
Programa(s)
Régimen de financiación
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinador
B15 2TT Birmingham
Reino Unido