Description du projet
Nouveaux biomatériaux pour l’ingénierie tissulaire
Les polycarbonates aliphatiques sont des composés qui contiennent le groupe chimique -O-C(O)-O- dans une structure non aromatique. Ces dernières années, nous avons assisté à un regain d’intérêt pour ces molécules en raison des progrès réalisés dans leur production. Leur biocompatibilité et leur dégradation sans acide sont des caractéristiques attrayantes qui font des polycarbonates aliphatiques un matériau idéal pour les biomatériaux, car ils ne provoquent pas d’inflammation des tissus. De plus, ils peuvent être fonctionnalisés, et donc servir d’implants et de vecteurs de médicaments. Le projet PhotoPolyCarb, financé par l’UE, travaille sur une approche d’impression 3D qui utilise des polycarbonates aliphatiques pour générer des biomatériaux à des fins d’ingénierie tissulaire. Cette approche constitue une avancée vers le développement d’implants sur mesure, qui ont le potentiel d’améliorer la santé et la qualité de vie des patients.
Objectif
Over the past years, aliphatic polycarbonates (APCs) have gained prominence in the biomedical field in reason of their features allied to their in vivo bioresorbability. Unlike polyesters, the degradation products of APCs are acid free, which prevents tissue inflammation and drug denaturation upon their use as implants and drug vehicles, making them a potential material in the medical field. Simultaneously, the 3D printing of biomaterials has recently advanced the development of tailor-made implants, which can improve the patients’ health and quality of life. However, the translative impact of 3D printing to clinical use is still beset with limitations, including the brittle nature of the properties of materials that are available, the crosslinking chemistries that hinder translation into cell-laden biomaterials and toxicity of residual monomers and additives. PhotoPolyCarb aims to overcome these limitations by combining functional photoreactive polycarbonates from different topographies with stereolithography (SLA), thus avoiding the use of toxic monomers and photoinitiators during the printing process. In a transfer of knowledge, PhotoPolyCarb will bring together the expertise of the researchers in areas such as chemical engineering reactions (from the applicant), polymer chemistry (from the host) and bioengineering (from the secondment). The fellowship will permit the applicant to work with world-renowned research groups in the field of biomaterials and tissue engineering, allowing her to develop skills in an interdisciplinary environment and consolidate her career. The dissemination of research results will target the professional audience as well the public through outreach activities.
Champ scientifique
- medical and health sciencesmedical biotechnologytissue engineering
- natural scienceschemical sciencespolymer sciences
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- engineering and technologyindustrial biotechnologybiomaterials
- medical and health sciencesmedical biotechnologyimplants
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
B15 2TT Birmingham
Royaume-Uni