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Systematic identification of genetic modifiers in the response to targeted therapies in acute myeloid leukemia.

Project description

Profiling cancer response to drugs

Emerging evidence suggests that anti-cancer drugs targeting oncogene-associated products often lead to resistance, impeding therapy. Given that the mechanisms of drug resistance remain elusive, the EU-funded AML-SynergyX project aims to understand how acute myeloid leukaemia (AML) cells respond to small-molecule inhibitors against common AML gene rearrangements or targets such as FLT3 and MLL. Researchers will employ genetic and transcriptome technologies to profile the primary response and adaptation of cancer cells to drug inhibition. Overall, the work will assist in the design of new drugs and the choice of combinatorial treatments for improved clinical outcome.

Call for proposal

H2020-MSCA-IF-2020
See other projects for this call

Coordinator

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Address
Campus-vienna-biocenter 1
1030 Wien
Austria
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 186 167,04