Project description DEENESFRITPL Assessing effects of drugs and pollutants on foetal health The preterm birth rate is increasing: in Europe, about 75 % of all neonatal deaths and 60 % of all infant deaths occur in infants born preterm. Based on the vision that every pregnant woman must live in a better and safer environment, the EU-funded LIFESAVER project will create a new digitally cloned in vitro system for emulation of prenatal conditions for drugs and pollutants transport at the uterine/placental interface. The system relies on the hybridisation of innovative technologies, integrating in silico/in vitro systems to enable screening for chemicals and pharmaceuticals that could affect the health of pregnant women, and at the same time reducing animal, pre-clinical and clinical testing needs. Show the project objective Hide the project objective Objective In Europe about 75% of all neonatal deaths and 60% of all infant deaths occur in infants born preterm, and worldwide 450 neonatal deaths occur every hour. The number of preterm births is growing despite advances in medicine as more pregnancies are in the later age but also due to increasing environmental treats and lack of suitable treatments. In the LIFESAVER vision, every pregnant woman must have a proper living environment with the minimal risks to the fetus, safeguarded with scientifically justified regulations in use and control of potentially risky chemical and medicinal products, leading to healthier quality lives of the babies, overarching for generations. The LIFESAVER addresses the presently unmet societal and healthcare needs in creating and developing of a validated scientific knowledge base for the development and implementation of regulatory approaches relevant to maternal and fetal health. The objective is in creation of new, digitally cloned in vitro system for emulation of the pre-natal conditions in the vicinity of uterine/placental interface, capable of future high biofidelity prediction of safety and risk of substances towards unborn babies. LIFESAVER concept is based on an original idea of hybridization of several innovative technologies, integrating digital in silico/in vitro (biodigital twin) systems, enabling effective screening of chemicals and pharmaceuticals which might affect pregnant women health, reducing animal, preclinical and clinical testing, which is not presently possible with any other existing approaches to the same level of confidence.The outcomes are in design, manufacturing and deployment of a platform having key components of in vitro placental tissue for sufficient emulation of typical prenatal conditions. This aims to provide a solid scientific rationale for new regulations for chemical and pharmaceutical use relevant for the Green Deal vision. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineobstetricsfetal medicinemedical and health sciencesclinical medicineembryology Programme(s) H2020-EU.3.5. - SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials Main Programme Topic(s) LC-GD-8-2-2020 - Fostering regulatory science to address combined exposures to industrial chemicals and pharmaceuticals: from science to evidence-based policies Call for proposal H2020-LC-GD-2020 See other projects for this call Sub call H2020-LC-GD-2020-3 Funding Scheme RIA - Research and Innovation action Coordinator ENGINSOFT SPA Net EU contribution € 799 925,00 Address Via della stazione 27 38100 Trento Italy See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (14) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SEQVERA LTD. OY Finland Net EU contribution € 404 950,00 Address Terkko health hub, bldg.14, haartmaninkatu 4 00290 Helsinki See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA CATTOLICA DEL SACRO CUORE Italy Net EU contribution € 335 687,50 Address Largo gemelli 1 20123 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. FONDAZIONE POLIAMBULANZA Italy Net EU contribution € 165 750,00 Address Via bissolati 57 25124 Brescia See on map Region Nord-Ovest Lombardia Brescia Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ELVESYS France Net EU contribution € 528 062,00 Address 172 rue de charonne b2 2 eme etage 75011 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,50 EVERCYTE GMBH Austria Net EU contribution € 427 862,50 Address Leberstrasse 20/8 1110 Wien See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 LABORATORIO IBERICO INTERNACIONAL DE NANOTECNOLOGIA LIN Portugal Net EU contribution € 397 750,00 Address Avenida mestre jose veiga 4715-330 Braga See on map Region Continente Norte Cávado Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BICO GROUP AB Sweden Net EU contribution € 423 112,50 Address Arvid wallgrens backe 20 413 46 Goteborg See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Södra Sverige Västsverige Västra Götalands län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PRO-ACTIVE Belgium Net EU contribution € 421 950,00 Address Avenue des pinsons 32 1410 Waterloo See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NATIONAL UNIVERSITY OF IRELAND GALWAY Ireland Net EU contribution € 400 975,00 Address University road H91 Galway See on map Region Ireland Northern and Western West Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ISTITUTO NAZIONALE DI RICERCA METROLOGICA Italy Net EU contribution € 401 700,00 Address Strada delle cacce 91 10135 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE PLANET CALLS COMPANY LIMITED BY GUARANTEE Ireland Net EU contribution € 335 162,50 Address Ground floor, 71 lower baggot street D02 P593 Dublin See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ireland Eastern and Midland Dublin Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 IDEA STRATEGISCHE ECONOMISCHE CONSULTING Belgium Net EU contribution € 411 450,00 Address Jozef ii straat 40 1000 Bruxelles / brussel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MALTA LIFE SCIENCES CENTRE LIMITED Malta Net EU contribution € 169 612,50 Address Malta enterprise, guardamangia hill MEC0001 Pieta See on map Region Malta Malta Malta Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO Portugal Net EU contribution € 512 562,50 Address Rua alfredo allen 208 4200-135 Porto See on map Region Continente Norte Área Metropolitana do Porto Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
