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Living Impact on Fetal Evolution: Shelter-Analyze-Validate-Empower Regulations

Project description

Assessing effects of drugs and pollutants on foetal health

The preterm birth rate is increasing: in Europe, about 75 % of all neonatal deaths and 60 % of all infant deaths occur in infants born preterm. Based on the vision that every pregnant woman must live in a better and safer environment, the EU-funded LIFESAVER project will create a new digitally cloned in vitro system for emulation of prenatal conditions for drugs and pollutants transport at the uterine/placental interface. The system relies on the hybridisation of innovative technologies, integrating in silico/in vitro systems to enable screening for chemicals and pharmaceuticals that could affect the health of pregnant women, and at the same time reducing animal, pre-clinical and clinical testing needs.


In Europe about 75% of all neonatal deaths and 60% of all infant deaths occur in infants born preterm, and worldwide 450 neonatal deaths occur every hour. The number of preterm births is growing despite advances in medicine as more pregnancies are in the later age but also due to increasing environmental treats and lack of suitable treatments.
In the LIFESAVER vision, every pregnant woman must have a proper living environment with the minimal risks to the fetus, safeguarded with scientifically justified regulations in use and control of potentially risky chemical and medicinal products, leading to healthier quality lives of the babies, overarching for generations.
The LIFESAVER addresses the presently unmet societal and healthcare needs in creating and developing of a validated scientific knowledge base for the development and implementation of regulatory approaches relevant to maternal and fetal health. The objective is in creation of new, digitally cloned in vitro system for emulation of the pre-natal conditions in the vicinity of uterine/placental interface, capable of future high biofidelity prediction of safety and risk of substances towards unborn babies. LIFESAVER concept is based on an original idea of hybridization of several innovative technologies, integrating digital in silico/in vitro (biodigital twin) systems, enabling effective screening of chemicals and pharmaceuticals which might affect pregnant women health, reducing animal, preclinical and clinical testing, which is not presently possible with any other existing approaches to the same level of confidence.
The outcomes are in design, manufacturing and deployment of a platform having key components of in vitro placental tissue for sufficient emulation of typical prenatal conditions. This aims to provide a solid scientific rationale for new regulations for chemical and pharmaceutical use relevant for the Green Deal vision.

Call for proposal


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Net EU contribution
€ 799 925,00
Via della stazione 27
38100 Trento

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Nord-Est Provincia Autonoma di Trento Trento
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00

Participants (14)