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CORDIS

Living Impact on Fetal Evolution: Shelter-Analyze-Validate-Empower Regulations

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Microfluidic set-up validated in lab conditions (opens in new window)

D3.4. Demonstrated microfluidic set-up validated in lab conditions with parameters and measured outcomes (M42) (MIC, i3S, INRIM, INL, NUI). This deliverable relates to T3.4, comprising results of the validation of the microfluidic system operations, complemented with a relevant statistical assessment of its reliability and out-comes.

Short brief: relevant policy status (opens in new window)

D8.1 Short brief about the relevant policy status (M18) (IDEA, PROA). This deliverable relates to T8.1, compris-ing the first mapping of needs and options to impose, modify or develop new regulations based on existing in¬for¬ma¬tion.

Report on the held DICO workshops - Update 2 (opens in new window)

D6.10 Report on the held DICO workshops - Update 2 (M36) (TPC). This deliverable relates to T6.4.

Performed experiments with statistical analysis (opens in new window)

D5.2 Summary report of the performed in vitro experiments with statistical reliability analysis (M42) (INL, MIC, ES, SEQ). This deliverable relates to T5.2, reporting on main performing experiments, their outcomes and respective statistical analysis.

Training activities & STEMs outcomes - Update 3 (opens in new window)

D6.14 Report on training activities and STEMs outcomes - Update 3 (M48) (MLSC, TPC, ES). This deliverable re-lates to T6.4.

Project business and stakeholders pitches (opens in new window)

D7.7 Project business and stakeholders pitches (M48) (PROA, SEQ, CI, ES, EVCYT, MIC, TPC, IDEA, MSLC). This deliverable relates to T7.5, reporting the plans and pathways to access specific markets segments and poten-tial alliances, with options to access to finance.

Report on the held DICO workshops - Update 1 (opens in new window)

D6.9 Report on the held DICO workshops - Update 1 (M18) (TPC). This deliverable relates to T6.4.

Mechanical properties of bioprinted constructs (opens in new window)

D2.3. Report on analysed and optimized mechanical properties of the bioprinted constructs for LIFESAVER elements (M30) (SEQ, i3S, INL, INRIM). This deliverable relates to T2.2 comprising the results of biomechani-cal assessment of the properties of the bioprinted constructs and data on normal uterine and decidua vis-costiffness, memory parameters with tissue orientation, location, anisotropy, frequency, applicable defor-mation strain (to the extent required for the objectives of the LIFESAVER).

Short brief: policy update recommendations (opens in new window)

D8.3 Short brief about the policy update recommendations (M48) (IDEA). This deliverable relates to T8.1 and T8.4, integrating policy update recommendations based on LIFESAVER results.

Bioink characterisation results (opens in new window)

D2.2. Bioinks physical, chemical and biological characterisation results (M18) (CELLINK, SEQ, NUI, INL, i3S, EVCYT). This deliverable relates to the second subtask of the Task T2.1 comprising results of characterized properties of the bioinks, relevant for bioprinting (flowability, construct rigidisation, viscosity, shear properties, nozzle compatibility, rate, printing precision, etc.) and for the cells com¬pa¬ti¬bi¬lity during and after the printing pro-cess.

Landscape analysis of current policy framework (opens in new window)

D8.2 Analytical report with landscape analysis of current policy framework relevant to LIFESAVER and a gap analysis (M36) (IDEA, PROA). This deliverable relates to T8.1, T8.2 and T8.4, including overview of the cur¬rent state of the art of EU policies regarding chemicals and pharmaceuticals related to LIFESAVER.

Testing results with blank runs (opens in new window)

D3.3. Testing results of microfluidic system with blank runs (M25) (ELV, i3S, NUI, INL, INRIM). This deliverable relates to T3.3 comprising results of the baseline (blank) tests for demonstration of the feasibility of the mi-crofluidic system operations.

Training activities & STEMs outcomes - Update 1 (opens in new window)

D6.12 Report on training activities and STEMs outcomes - Update 1 (M18) (MLSC, TPC, ES). This deliverable re-lates to T6.4.

Optimized BDT parameters and SOPs (opens in new window)

D1.3 Report on optimized parameters for the LIFESAVER device and SOPs recommendations (M36) (INRIM, ES, SEQ, i3S, INL, NUI). This deliverable relates to T1.3 comprising re¬com¬¬men¬dations for the in vitro/in silico twinning and obtained biofidelity, high¬lighting the limitations and appli¬ca¬tion limits of the LIFESAVER

Report on the held DICO workshops - Update 3 (opens in new window)

D6.11 Report on the held DICO workshops - Update 3 (M48) (TPC). This deliverable relates to T6.4.

General outcome of the LIFESAVER technology (opens in new window)

D5.3 Report on the general outcomes, features and limitations of the LIFESAVER technology (M48) (i3S, ES, INRIM, MIC). This deliverable relates to T5.3, comprising results real-to-virtual testing correlations (biodigital twinning) and of quantifications of endpoints which expected to have a higher reproducibility than other methods, allowing also the design of future clinical trials and environmental exposure margins to be assessed with much smaller cohorts.

Training activities & STEMs outcomes - Update 2 (opens in new window)

D6.13 Report on training activities and STEMs outcomes - Update 2 (M36) (MLSC, TPC, ES). This deliverable re-lates to T6.4.

Existing relevant regulatory constraints (opens in new window)

D8.4 Analytical report on existing regulatory constraints relevant to the LIFESAVER objectives (M40) (IDEA). This deliverable relates to T8.3, providing data on possible regulatory constrains needed to be addressed.

The first operational version of the LIFESAVER (opens in new window)

D5.1 Demonstrated the first operational version of the LIFESAVER microfluidic system with proper controls and interfaces (M18) (ELV, INL, i3S). This deliverable relates to T5.1 including results of the demonstration of the feasibility of operation of the microfluidic hardware with the proper controls and ad sensors.

Feasible hACM tissues for RACE construction (opens in new window)

D2.1. Demonstration of feasible hACM-based tissues prepared for RACE construction (M24) (EVCYT, UCSC, i3S, NUI, INRIM). This deliverable relates to the first subtask of the Task T2.1 comprising results and demon-stration of suitability of autologous/allogenic from another hACM source to be re-printed back in a controlled manner.

MCDA tool for analysis of biodigital twin data (opens in new window)

D4.4 Demonstrated MCDA tool for analysis of the biodigital twin data (M36) (ES, INRIM, SEQ). This deliverable connects with T4.4, including demonstration of the application of the MCDA method integrating LIFESAVER outcomes and endpoints.

Improved feasible bioprinted REPE construct (opens in new window)

D2.4. Demonstration of improved and feasible bioprinted REPE construct (M36) (CELLINK, INL, i3S, NUI, EVCYT). This deliverable is linked to T2.3 comprising the results and demonstration of the imporved biofabricated REPE element for in vitro testing.

Policy toolbox regarding medicines safety (opens in new window)

D8.5 Policy toolbox regarding chemicals and medicines safety for pregnant women health (M48) (IDEA). This deliverable relates to T8.5, comprising results on development and summarization of the policy toolbox for policy recommendations to help policy makers to identify the best approach to design policy measures.

The final DMP report (opens in new window)

D6.3 The final DMP report (M48) (ES, ALL). This deliverable relates to T6.2, reflecting the final version of the DMP plan.

Project website opened (opens in new window)

D6.1 Project website opened (M3) (TPC, ES). This deliverable relates to T6.1.

Release of DMP - Data Management Plan (opens in new window)

D6.2 Release of DMP (M6) (ES, ALL). This deliverable is related to Open Research Data Pilot (ORDP). This deliv-erable relates to T6.2.

Publications

LIFESAVER featured in Green Deal Support Office Newsletter

Author(s): Green Deal Support Office
Published in: 2024
Publisher: Green Deal Support Office

LIFESAVER feature in Green Deal Support Office Brochure

Author(s): Green Deal Support Office
Published in: 2023
Publisher: Green Deal Support Office

LIFESAVER featured in Green Deal Support Office Newsletter

Author(s): Green Deal Support Office
Published in: 2025
Publisher: Green Deal Support Office

ConcePTION & LIFESAVER – Joining forces to improve maternal health & pregnancy pharmacovigilance

Author(s): IMI ConcePTION & LIFESAVER
Published in: 2024
Publisher: IMI-ConcPTION

ALTERNATIVE & LIFESAVER Workshop Regulatory Innovation and Health Safety

Author(s): ALTERNATIVE & LIFESAVER
Published in: 2024
Publisher: ALTERNATIVE

Fraction collector for microfluidic cell culture

Author(s): Microfluidics Innovation Center - Lisa Muiznieks
Published in: 2024
Publisher: Microfluidics

LIFESAVER Project Video on YouTube by Green Deal Support Office

Author(s): Green Deal Support Office
Published in: 2024
Publisher: Green Deal Support Office

LIFESAVER featured in Green Deal Support Office Video

Author(s): Green Deal Support Office
Published in: 2023
Publisher: Green Deal Support Office

Bisphenol A Disrupts Mitochondrial Functionality Leading to Senescence and Apoptosis in Human Amniotic Mesenchymal Stromal Cells (opens in new window)

Author(s): Sara Ficai, Andrea Papait, Marta Magatti, Alice Masserdotti, Michael Gasik, Antonietta Rosa Silini, Ornella Parolini
Published in: Cell Death Discovery, Issue 11, 2025, Page(s) 327, ISSN 2058-7716
Publisher: Springer-Nature
DOI: 10.1101/2024.08.29.610279

AptaShield: A Universal Signal-Transduction System for Fast and High-Throughput Optical Molecular Biosensing (opens in new window)

Author(s): Miguel António Dias Neves, Inês Mendes Pinto
Published in: ACS Sensors, Issue 9, 2024, Page(s) 1756-1762, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.3c02762

Multi‐Parametric Decision System for Analytical Performance Assessment of Electrochemical (Bio)Sensors (opens in new window)

Author(s): Daniel C. Moreira, Duarte Nuno Carvalho, Evelyn C. Santos, João B. Relvas, Miguel António Dias Neves, Inēs Mendes Pinto
Published in: Advanced Materials Technologies, Issue 9, 2024, ISSN 2365-709X
Publisher: Wiley-VCH GmbH
DOI: 10.1002/admt.202301464

Standard Operating Procedure to Optimize Resazurin-Based Viability Assays (opens in new window)

Author(s): Jessica Petiti, Laura Revel, Carla Divieto
Published in: Biosensors, Issue 14, 2024, Page(s) 156, ISSN 2079-6374
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios14040156

Unveiling the human fetal-maternal interface during the first trimester: biophysical knowledge and gaps (opens in new window)

Author(s): Alice Masserdotti, Michael Gasik, Regina Grillari-Voglauer, Johannes Grillari, Anna Cargnoni, Paola Chiodelli, Andrea Papait, Marta Magatti, Jacopo Romoli, Sara Ficai, Lorena Di Pietro, Wanda Lattanzi, Antonietta Rosa Silini, Ornella Parolini
Published in: Frontiers in Cell and Developmental Biology, Issue 12, 2024, ISSN 2296-634X
Publisher: Springer Nature
DOI: 10.3389/fcell.2024.1411582

Standardized Protocol for Resazurin-Based Viability Assays on A549 Cell Line for Improving Cytotoxicity Data Reliability (opens in new window)

Author(s): Petiti Jessica, Caria Sabrina, Revel Laura, Pegoraro Mattia, and Divieto Carla
Published in: Cells, 2024, ISSN 2073-4409
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/cells13231959

Intellectual Property Rights

MODEL-FREE TIME-INVARIANT EVALUATION OF TRANSPORT AND EFFICACY OF CHEMICALS AND DRUGS

Application/Publication number: 20 2217875843
Date: 2022-07-28
Applicant(s): SEQVERA LTD. OY

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