environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Información del proyecto

ALTERNATIVE

Identificador del acuerdo de subvención: 101037090

DOI

10.3030/101037090

Proyecto cerrado

Fecha de la firma de la CE 2 Septiembre 2021

Fecha de inicio 1 Octubre 2021

Fecha de finalización 31 Marzo 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Climate action, Environment, Resource Efficiency and Raw Materials

Coste total

€ 5 499 757,25

Aportación de la UE

€ 5 499 757,25

Coordinado por

POLITECNICO DI TORINO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Draft Guidance for regulatory use of the ALTERNATIVE platform

The guidance will include a detailed characterization of the individual ALTERNATIVE platform methods and describe how the data generated with these methods should be used by regulators, either as such or as a building block of the developed IATA for cardiotoxicity (D2.4). This deliverable is linked to T7.2 and could contain policy relevant information as it relates to how regulators should use/interpret information obtained by the ALTERNATIVE platform.

Intermediate dissemination and communication report

Provides an impact assessment of the dissemination and communication activities performed in the first 18 months of the project according to the plan outlined in D8.1. It describes the major performed activities and provides an updated plan for dissemination and communication in the second half of the project. This deliverable is linked to T8.1.

Documentation of regulatory needs for cardiotoxicity methods and data which can be used for consultation of national and European PARERE networks

Current regulatory data requirements across regulations will be reviewed and contextualized with ongoing European policy initiatives, scientific concern for cardiotoxicity and options for NAM based improvements. The resulting report shall be easily readable for regulators, shall contain questions for regulators and will be disseminated within the WP leads PARERE network of regulators. The resulting feedback will be evaluated. This deliverable is linked to T2.1 and is a policy related document.

Initial dissemination and communication plan

Describes the dissemination and communication strategy for the whole project and especially the first period up to M18. It describes the goals and target audiences and outlines the major planned dissemination and communication activities for the first half of the project. This deliverable is linked to T8.1.

Toxicological evidence

Systematic reviews for the identified compounds published as monographs and/or in scientific journals. This deliverable is linked to T3.2.

Open Research Data Pilot (1)

Data management plan

Outlines the data management policy and methods applicable to ALTERNATIVE data. It details actions for the overall control of data and summarises the types of data and sources, as well as how to handle the data. This deliverable is linked to T8.2.

Publicaciones

Peer reviewed articles (9)

A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)

Autores: G. Donzelli, F. Sera, M.A. Morales, F. Vozzi, T. Roos, A. Schaffert, M. Paparella, S. Murugadoss, B. Mertens, R. Gehring, N. Linzalone
Publicado en: Environmental Research, Edición 249, 2024, Página(s) 118429, ISSN 0013-9351
Editor: Academic Press
DOI: 10.1016/j.envres.2024.118429

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Autores: Gianluca Ciardelli, Monica Boffito, Arianna Grivet-Brancot
Publicado en: Macromolecular bioscience, 2022, Página(s) -
Editor: Wiley Online Library
DOI: 10.1002/mabi.202200039

Artificial Intelligence and Machine Learning Methods to Evaluate Cardiotoxicity following the Adverse Outcome Pathway Frameworks

Autores: Edoardo Luca Viganò, Davide Ballabio, Alessandra Roncaglioni
Publicado en: Toxics, Edición 12, 2024, Página(s) 87, ISSN 2305-6304
Editor: MDPI
DOI: 10.3390/toxics12010087

P14-03 Addressing cardiotoxicity in environmental chemical regulation: an integrated approach to cardiotoxicity testing

Autores: A. Schaffert, S. Murugadoss, B. Mertens, M. Paparella
Publicado en: Toxicology Letters, Edición 399, 2024, Página(s) S226-S227, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.556

Cardiac tissue engineering: Multiple approaches and potential applications

Autores: Ilaria Gisone, Antonella Cecchettini, Elisa Ceccherini, Elisa Persiani, Maria Aurora Morales, Federico Vozzi
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 3, 2022, Página(s) 1, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2022.980393

CEC01-01 Introduction into the AOP framework: Integrating Theory and Practice in AOP Development

Autores: A. Schaffert, S. Murugadoss
Publicado en: Toxicology Letters, Edición 399, 2024, Página(s) S4, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.014

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Autores: Pietro Delre, Giovanna J. Lavado, Giuseppe Lamanna, Michele Saviano, Alessandra Roncaglioni, Emilio Benfenati, Giuseppe Felice Nagiatordi, Domenico Gadaleta
Publicado en: Frontiers in Pharmacology, Edición 13, 2022, Página(s) 1-13, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.951083

Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Autores: Nunzia Linzalone, Maria Aurora Morales, Federico Vozzi, Gabriele Donzelli
Publicado en: International Journal of Environmental Research and Public Health, Edición 19, 2022, Página(s) 1-8, ISSN 1661-7827
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19127482

Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals

Autores: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Alexandra Schaffert
Publicado en: Alternatives to Animal Experimentation, Edición Vol. 41 No. 1 (2024), 2024, Página(s) 14, ISSN 1868-8551
Editor: ALTEX
DOI: 10.14573/altex.2305011

Conference proceedings (23)

Designing 3D bioengineered in vitro cardiac tissue models as reliable tools for the evaluation of chemical cardiotoxicity

Autores: Monica Boffito, Susanna Sartori, Valeria Chiono, Federico Vozzi, Arianna Grivet-Brancot, Rossella Laurano,Roberta Pappalardo, Gianluca Ciardelli
Publicado en: ALTEX proceedings, Edición Volume 10, page 64, No. 2, (2022), 2022
Editor: ALTEX Edition
DOI: 10.5281/zenodo.8367045

A Comprehensive Approach to Cardiotoxicity Assessment using Adverse Outcome Pathways

Autores: A. Schaffert, S. Murugadoss, B. Mertens, T. Roos, R. Gehring, N. Linzalone, G. Donzelli, M. Paparella
Publicado en: ALTEX Proceedings, 2024
Editor: ALTEX Edition
DOI: 10.58847/ap2402

Engineering 3D in vitro cardiac tissue models for cardiotoxicity assessment

Autores: Vozzi, F., Boffito, M., Gisone, I., Cecchettini, A., Del Ry, S., Cabiati, M., Sartori, S., Laurano, R., Grivet-Brancot, A., Pappalardo, R., & Ciardelli, G.
Publicado en: 2022
Editor: Biofabrication 2022
DOI: 10.5281/zenodo.8177565

Custom-made poly(ester urethane) tailored for 3D printing by Fused Deposition Modelling

Autores: Gianluca Ciardelli, Andrea Alliaud, Ariana Grivet Brancot, Rosella Laurano, Susanna Sartori, Moncia Boffito
Publicado en: TERMIS, 2023, Página(s) 843
Editor: TERMIS 2023 conference
DOI: 10.5281/zenodo.8186421

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Autores: Sivakumar Murugadoss, Alexandra Schaffert, Ronette Gehring, Tom Roos, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella, Birgit Mertens
Publicado en: 2023
Editor: ASPIS Open Symposium 2023
DOI: 10.5281/zenodo.11382201

Tissue replica generation: the multifaceted contributions of cells and biomaterials

Autores: Federico Vozzi
Publicado en: 2023
Editor: ESB2023
DOI: 10.5281/zenodo.11367853

BIOENGINEERED 3D CARDIAC TISSUE MODEL FOR CARDIOTOXICITY STUDIES

Autores: Ilaria Gisone, Andrea Alliaud, Elisa Persiani, Rossella Laurano, Elisa Ceccherini, Maria Aurora Morales, Monica Boffito, Antonella Cecchettini, Gianluca Ciardelli
Publicado en: Abstracts of the 2nd Microphysiological Systems World Summit 2023, 2023
Editor: Altex
DOI: 10.58847/ap.2301

Design of 3D bioengineered cardiac tissue models for the evaluation of chemical cardiotoxicity

Autores: Ciardelli, Gianluca; Grivet-Brancot, Arianna; Chiono, Valeria; Sartori, Susanne, & Boffito, Monica
Publicado en: 2022
Editor: ESB 2022 conference
DOI: 10.5281/zenodo.8178217

ALTERNATIVE platform: an innovative tool for chemical cardiotoxicity detection

Autores: Gianluca Ciardelli, Susanna Sartori, Andrea Alliaud, Arianna Grivet-Brancot, Monica Boffito, Silvia Del Ry, Manuela Cabiati, Elisa Persiani, Elisa Ceccherini, Antonella Cecchettini, Federico Vozzi
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.11353657

Multi-omics fingerprint of in vitro bioengineered heart-on-chip platform

Autores: Ilaria Gisone, Maria Guirro, Lorena García, Nerea Abasolo, Federico Vozzi, Nuria Canela, Salvador Fernández Arroyo
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.11400752

3D printed PU/GelMA biphasic scaffold as cardiac tissue model.

Autores: Susanna Sartori, Andrea Alliaud, Monica Boffito, Gianluca Ciardelli, Arianna Grivet-Brancot
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.11353780

The role of physiologically based kinetic modeling in interpreting the results of in vitro cell-based toxicity assays

Autores: Ronette Gehring
Publicado en: ESB2022 Main abstract book, 2022, Página(s) 333
Editor: ESB2022 conference
DOI: 10.5281/zenodo.8185809

Engineering of poly(urethane)-based porous constructs for cardiac tissue model design

Autores: Andrea Alliaud, Monica Boffito, Rossella Laurano, Susanna Sartori, Gianluca Ciardelli
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.11350948

Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes

Autores: Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blüher, John T. Heiker, Jörg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen, Kristin Schubert
Publicado en: ALTEX proceedings, Edición Volume 10, No. 2, (2022), 2022, Página(s) 202, ISSN 2194-0479
Editor: ALTEX
DOI: 10.5281/zenodo.8367087

Evidenze sull'associazione tra l'esposizione a sostanze tossiche ambientali e disfunzione ventricolare sinistra: protocollo per una revisione sistematica e meta-analisi di letteratura.

Autores: Nunzia Linzalone, Gabriele Donzelli, Maria Aurora Morales, Federico Vozzi
Publicado en: 2022
Editor: XLVI Convegno dell’Associazione Italiana di Epidemiologia. Decisioni in contesti di incertezza: il ruolo dell'epidemiologia
DOI: 10.5281/zenodo.8177446

Collagen-derived biomaterials in tissue engineering and organ modelling

Autores: Ciardelli, Gianluca; Boffito, Monica; Tonda-Turo, Chiara; & Chiono, Valeria
Publicado en: 2022
Editor: ESIB CONFERENCE
DOI: 10.5281/zenodo.8177934

3D printed PU/GelMA biphasic scaffold for detecting the cardiotoxicity of chemicals

Autores: Susanna Sartori, Gianluca Ciardelli, Andrea Alliaud, Monica Boffito, Federico Vozzi, Ilaria Gisone, Antonella Cecchettini, Manuela Cabiati, Letizia Guiducci, Silvia Del Ry
Publicado en: 2022
Editor: Zenodo
DOI: 10.5281/zenodo.11352529

LIFTING THE BURDEN FROM ANIMALS AND THE HEART: A COMPREHENSIVE APPROACH TO CARDIOTOXICITY EVALUATION

Autores: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli, Martin Paparella
Publicado en: 2023
Editor: Austrian 3R Center
DOI: 10.5281/zenodo.11350443

Co-culture of hiPSC-CMs and ECs to mimic cardiac tissue

Autores: Ilaria Gisone, Manuela Cabiati, Elisa Ceccherini, Elisa Persiani, Letizia Guiducci, Antonella Cecchettini, Monica Boffito, Rossella Laurano, Gianluca Ciardelli, Federico Vozzi
Publicado en: 2023
Editor: SIOoC
DOI: 10.5281/zenodo.11368020

From Data Exploration to Predictive Models: Advanced ML and AI Techniques for Cardiotoxicity Analysis

Autores: Edoardo Viganò, Alessandra Roncaglioni
Publicado en: biomedical science and engineering, Edición Volume 4, No. 1, 2023, ISSN 2531-9892
Editor: Pagepress
DOI: 10.4081/bse.226

ALTERNATIVE - Horizon 2020 project for building an innovative platform to assess the cardiotoxicity of chemicals

Autores: Gianluca Ciardelli
Publicado en: 2022
Editor: ESB 2022 conference
DOI: 10.5281/zenodo.11279640

Microfluidics for the pharmacological characterization of compounds on neurotransmitters transporters

Autores: Francesca Romana Brugnoli, Benjamin Garlan
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.11350781

Reducing the Burden on Animals and the Heart: An Evidence-Based Approach to Cardiotoxicity

Autores: Alexandra Schaffert, Sivakumar Murugadoss, Martin Paparella, Birgit Mertens, Tom Roos, Ronette Gehring, Nunzia Linzalone, Gabriele Donzelli
Publicado en: Abstracts of the 12th World Congress on Alternatives and Animal Use in the Life Sciences, Niagara Falls 2023, 2023
Editor: ALTEX
DOI: 10.58847/ap.2302

Other (11)

White paper on REGULATION OF CHEMICAL EXPOSURES AND CARDIAC HEALTH: CURRENT GAPS AND FUTURE SOLUTIONS

Autores: A. Schaffert, S. Murugadoss, M. Paprella, B. Mertens, A. Gavras, P. Mohnani
Publicado en: 2023
Editor: Zenodo
DOI: 10.5281/zenodo.10021900

TAILOR-MADE POLYMERS: AN ADDITIONAL DEGREE OF FREEDOM IN THE TUNING OF MECHANICAL PROPERTIES IN TISSUE MODELING

Autores: Gianluca Ciardelli
Publicado en: 2022
Editor: Zenodo
DOI: 10.5281/zenodo.12705562

The role of physiologically-based kinetic (PBK) models within the new approach methodologies framework for predicting cardiotoxicity

Autores: Ronette Gehring, Tom Roos, Zhicheng Zhang
Publicado en: 2022
Editor: EUSAAT congress
DOI: 10.5281/zenodo.11281251

ALTERNATIVE project flyer

Autores: Pooja Mohnani
Publicado en: 2021
Editor: ALTERNATIVE

White paper on MPS

Autores: Susanna Sartori, Federico Vozzi, Gianluca Ciardelli, Monica Boffito, Tommaso Sbrana, Miguel Berenguel Alonso, Salvador Fernández Arroyo, Adam Anglart
Publicado en: 2022
Editor: ALTERNATIVE project
DOI: 10.5281/zenodo.7350571

Innovative non-animal based testing platform to detect chemical-induced cardiotoxicity - A roadmap for regulatory uptake

Autores: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Nunzia Linzalone, Tom Roos, Alexandra Schaffert, Gabriele Donzelli
Publicado en: 2023
Editor: EUROTOX 2023
DOI: 10.5281/zenodo.11381430

Achieving zero pollution by 2050 needs regulatory change: a call for policy support of New Approach Methodologies (NAMs)

Autores: Martin Paparella, Alexandra Schaffert
Publicado en: 2024
Editor: Zenodo
DOI: 10.5281/zenodo.13378369

Monitoring environmental parameters in microfluidic cell culture

Autores: C. Betterelli Giuliano, L. Muiznieks, M. Kopf
Publicado en: 2022
Editor: Zenodo
DOI: 10.5281/zenodo.14923212

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Autores: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
Publicado en: 2023, Página(s) 337-340
Editor: ALTEX
DOI: 10.14573/altex.2301121

WHITE PAPER ON ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML) APPLIED TO TOXICOLOGY FOR HUMAN HEALTH PROTECTION WITH A FOCUS ON EPIDEMIOLOGY

Autores: N. Linzalone, F. Vozzi, B. Mertens
Publicado en: 2025
Editor: Zenodo
DOI: 10.5281/zenodo.14832230

Stimulating the regulatory acceptance of a novel platform developed for the assessment of chemical-induced cardiotoxicity

Autores: Sivakumar Murugadoss, Birgit Mertens, Martin Paparella, Ronette Gehring, Alexandra Schaffert, Tom Roos, Nunzia Linzalone
Publicado en: BELTOX ANNUAL MEETING 2022 ON THE CURRENT STATE OF KNOWLEDGE OF THE TOXICOLOGY AND ECOTOXICOLOGY OF PFAS, 2024
Editor: Beltox
DOI: 10.5281/zenodo.11381282

Non-peer reviewed articles (1)

S11-03 New Approach Methodologies for cardiac toxicity assessment: the ALTERNATIVE perspective

Autores: F. Vozzi
Publicado en: Toxicology Letters, Edición 399, 2024, Página(s) S25, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.1016/j.toxlet.2024.07.079

Book chapters (1)

Artificial Intelligence Methods for Evaluating Mitochondrial Dysfunction: Exploring Various Chemical Notations Suitable for Neural Language Processing Models

Autores: Edoardo Luca Viganò, Erika Colombo, Davide Ballabio, Alessandra Roncaglioni
Publicado en: Lecture Notes in Computer Science, AI in Drug Discovery, 2024, Página(s) 116-131
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-72381-0_10