Skip to main content
European Commission logo
español español
CORDIS - Resultados de investigaciones de la UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Descripción del proyecto

La exposición ambiental a productos químicos afecta seriamente al corazón

Los productos químicos tóxicos son muy comunes en el medio ambiente. Desde plaguicidas a restos de fármacos en el agua, el suelo, el aire y los organismos vivos, los seres humanos están constantemente expuestos a una gran cantidad y variedad de sustancias potencialmente tóxicas. Al mismo tiempo, se ha observado un aumento de la incidencia de enfermedades cardiovasculares, lo que ha llevado a plantear la hipótesis de que ambos fenómenos están vinculados. Para abordar esta cuestión, el equipo del proyecto ALTERNATIVE, financiado con fondos europeos, desarrollará una plataforma que permita identificar, cuantificar y prevenir la exposición conjunta cardiotóxica a productos químicos industriales y fármacos. La plataforma incluirá un modelo tridimensional «in vitro» que imita el tejido cardíaco humano, junto con un sistema de seguimiento fiable de alto rendimiento basado en análisis multiómicos e integrado en una herramienta de aprendizaje automático de evaluación de riesgos.

Objetivo

ALTERNATIVE will develop an innovative platform able to detect the cardiotoxicity of chemicals and their bio-transformation products. The novel platform will enable regulators and industry to identify, quantify and prevent cardiotoxic co-exposures to industrial chemicals and pharmaceuticals in a cost-effective way. ALTERNATIVE will particularly focus on cardiotoxic effects on older people, which is of high relevance in view of the ageing EU population and the high spread of cardiovascular diseases.
The platform will consist of a three-dimensional tissue engineering in-vitro model mimicking the human cardiac tissue, coupled with a reliable, high-throughput monitoring system based on multi-omics analyses, and integrated into a Machine Learning (ML) risk assessment tool. In addition, ALTERNATIVE will modify the tissue model to reproduce the aged myocardial tissue and elucidate the adverse effects of chemicals on older people. ALTERNATIVE?s proof-of-concept validation will be performed on well-known mixtures of pollutants, affecting different environmental compartments, and selected via epidemiological, toxicological and modelling expertise.
ALTERNATIVE will also provide systematic reviews of high-quality epidemiological studies to support integrated in vitro and in silico data, giving a more robust basis for regulatory decisions.
The ALTERNATIVE platform will be an innovative tool for complying with the current regulation associated with the assessment of chemical compounds. It will be a new instrument to evaluate unpredictable toxicity due to synergistic effects of different chemicals, additionally worsened by the human ageing process.
By introducing an in vitro cardiac system and ML models, ALTERNATIVE will provide a platform able to refine, reduce and replace the need for animal testing, providing close-to-real scenario information on toxicity and achieving a significant reduction of the associated direct and indirect costs.

Convocatoria de propuestas

H2020-LC-GD-2020

Consulte otros proyectos de esta convocatoria

Convocatoria de subcontratación

H2020-LC-GD-2020-3

Régimen de financiación

RIA - Research and Innovation action

Coordinador

POLITECNICO DI TORINO
Aportación neta de la UEn
€ 592 300,00
Dirección
CORSO DUCA DEGLI ABRUZZI 24
10129 Torino
Italia

Ver en el mapa

Región
Nord-Ovest Piemonte Torino
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
€ 592 300,00

Participantes (10)