environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model

Rezultaty

Intermediate dissemination and communication report

Provides an impact assessment of the dissemination and communication activities performed in the first 18 months of the project according to the plan outlined in D81 It describes the major performed activities and provides an updated plan for dissemination and communication in the second half of the project This deliverable is linked to T81

Documentation of regulatory needs for cardiotoxicity methods and data which can be used for consultation of national and European PARERE networks

Current regulatory data requirements across regulations will be reviewed and contextualized with ongoing European policy initiatives scientific concern for cardiotoxicity and options for NAM based improvements The resulting report shall be easily readable for regulators shall contain questions for regulators and will be disseminated within the WP leads PARERE network of regulators The resulting feedback will be evaluated This deliverable is linked to T21 and is a policy related document

Initial dissemination and communication plan

Describes the dissemination and communication strategy for the whole project and especially the first period up to M18 It describes the goals and target audiences and outlines the major planned dissemination and communication activities for the first half of the project This deliverable is linked to T81

Toxicological evidence

Systematic reviews for the identified compounds published as monographs andor in scientific journals This deliverable is linked to T32

Data management plan

Outlines the data management policy and methods applicable to ALTERNATIVE data It details actions for the overall control of data and summarises the types of data and sources as well as how to handle the data This deliverable is linked to T82

Publikacje

Designing 3D bioengineered in vitro cardiac tissue models as reliable tools for the evaluation of chemical cardiotoxicity

Autorzy: Monica Boffito, Susanna Sartori, Valeria Chiono, Federico Vozzi, Arianna Grivet-Brancot, Rossella Laurano,Roberta Pappalardo, Gianluca Ciardelli
Opublikowane w: ALTEX proceedings, Numer Volume 10, page 64, No. 2, (2022), 2022
Wydawca: ALTEX Edition
DOI: 10.5281/zenodo.8367045

Engineering 3D in vitro cardiac tissue models for cardiotoxicity assessment

Autorzy: Vozzi, F., Boffito, M., Gisone, I., Cecchettini, A., Del Ry, S., Cabiati, M., Sartori, S., Laurano, R., Grivet-Brancot, A., Pappalardo, R., & Ciardelli, G.
Opublikowane w: 2022
Wydawca: Biofabrication 2022
DOI: 10.5281/zenodo.8177565

Custom-made poly(ester urethane) tailored for 3D printing by Fused Deposition Modelling

Autorzy: Gianluca Ciardelli, Andrea Alliaud, Ariana Grivet Brancot, Rosella Laurano, Susanna Sartori, Moncia Boffito
Opublikowane w: TERMIS, 2023, Strona(/y) 843
Wydawca: TERMIS 2023 conference
DOI: 10.5281/zenodo.8186421

Design of 3D bioengineered cardiac tissue models for the evaluation of chemical cardiotoxicity

Autorzy: Ciardelli, Gianluca; Grivet-Brancot, Arianna; Chiono, Valeria; Sartori, Susanne, & Boffito, Monica
Opublikowane w: 2022
Wydawca: ESB 2022 conference
DOI: 10.5281/zenodo.8178217

The role of physiologically based kinetic modeling in interpreting the results of in vitro cell-based toxicity assays

Autorzy: Ronette Gehring
Opublikowane w: ESB2022 Main abstract book, 2022, Strona(/y) 333
Wydawca: ESB2022 conference
DOI: 10.5281/zenodo.8185809

Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes

Autorzy: Alexandra Schaffert, Isabel Karkossa, Elke Ueberham, Rita Schlichting, Katharina Walter, Josi Arnold, Matthias Blüher, John T. Heiker, Jörg Lehmann, Martin Wabitsch, Beate I. Escher, Martin von Bergen, Kristin Schubert
Opublikowane w: ALTEX proceedings, Numer Volume 10, No. 2, (2022), 2022, Strona(/y) 202, ISSN 2194-0479
Wydawca: ALTEX
DOI: 10.5281/zenodo.8367087

Evidenze sull'associazione tra l'esposizione a sostanze tossiche ambientali e disfunzione ventricolare sinistra: protocollo per una revisione sistematica e meta-analisi di letteratura.

Autorzy: Nunzia Linzalone, Gabriele Donzelli, Maria Aurora Morales, Federico Vozzi
Opublikowane w: 2022
Wydawca: XLVI Convegno dell’Associazione Italiana di Epidemiologia. Decisioni in contesti di incertezza: il ruolo dell'epidemiologia
DOI: 10.5281/zenodo.8177446

Collagen-derived biomaterials in tissue engineering and organ modelling

Autorzy: Ciardelli, Gianluca; Boffito, Monica; Tonda-Turo, Chiara; & Chiono, Valeria
Opublikowane w: 2022
Wydawca: ESIB CONFERENCE
DOI: 10.5281/zenodo.8177934

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Autorzy: Gianluca Ciardelli, Monica Boffito, Arianna Grivet-Brancot
Opublikowane w: Macromolecular bioscience, 2022, Strona(/y) -
Wydawca: Wiley Online Library
DOI: 10.1002/mabi.202200039

Cardiac tissue engineering: Multiple approaches and potential applications

Autorzy: Ilaria Gisone, Antonella Cecchettini, Elisa Ceccherini, Elisa Persiani, Maria Aurora Morales, Federico Vozzi
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 3, 2022, Strona(/y) 1, ISSN 2296-4185
Wydawca: Frontiers
DOI: 10.3389/fbioe.2022.980393

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Autorzy: Pietro Delre, Giovanna J. Lavado, Giuseppe Lamanna, Michele Saviano, Alessandra Roncaglioni, Emilio Benfenati, Giuseppe Felice Nagiatordi, Domenico Gadaleta
Opublikowane w: Frontiers in Pharmacology, Numer 13, 2022, Strona(/y) 1-13, ISSN 1663-9812
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fphar.2022.951083

Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Autorzy: Nunzia Linzalone, Maria Aurora Morales, Federico Vozzi, Gabriele Donzelli
Opublikowane w: International Journal of Environmental Research and Public Health, Numer 19, 2022, Strona(/y) 1-8, ISSN 1661-7827
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijerph19127482

ALTERNATIVE project flyer

Autorzy: Pooja Mohnani
Opublikowane w: 2021
Wydawca: ALTERNATIVE

White paper on MPS

Autorzy: Susanna Sartori, Federico Vozzi, Gianluca Ciardelli, Monica Boffito, Tommaso Sbrana, Miguel Berenguel Alonso, Salvador Fernández Arroyo, Adam Anglart
Opublikowane w: 2022
Wydawca: ALTERNATIVE project
DOI: 10.5281/zenodo.7350571

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs

Autorzy: Alexandra Schaffert, Sivakumar Murugadoss, Birgit Mertens, Martin Paparella
Opublikowane w: 2023, Strona(/y) 337-340
Wydawca: ALTEX
DOI: 10.14573/altex.2301121

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