PestNu addresses the reduction of pesticides and loss of nutrients by Digital and Space-based Technologies (DSTs) & Agro-ecological and Organic Practices (AOPs) systemic approach. The misuse and overdependence on hazardous pesticides and fertilizers cause environmental degradation, pollution of water, soil, and air. Biodiversity, is also experiencing a detrimental impact. Pesticide residues on fruits and vegetables pose health risks. Lastly, despite investments into Integrated Pest Management, Integrated Nutrient Management, and Precision Farming tools, progress has been underwhelming. Lack of harmonization at the EU level, insufficient international standards and low adoption rates of regulations by EU farmers contribute to this issue. Consequently, many precision farming tools and organic products lack real-world testing, and there is a need for technical solutions to support farmers, particularly those with small to medium-scale farms, in their decision-making and management processes. PestNu’s impacts are important for society for several reasons. Firstly, it decreases dependency on hazardous pesticides, promotes efficient organic farming, reducing pesticide associated risks and protecting the environment and human health. Secondly, PestNu reduces n loss of nutrients from fertilizers enhancing sustainable agricultural practices. It promotes recycled materials for producing fertilizers, contributing to a circular economy and reducing reliance on imported nutrients. Also, PestNu ensures sufficient, safe, nutritious, and affordable food, addressing food security concerns. It promotes food safety, new guidelines, policies, and standards. Moreover, facilitates digital transformation, enhancing food security, safety, and nurturing students in sustainable practices. It reduces greenhouse gas emissions, excess fertilizers and hazardous pesticide substances and promotes energy-efficient manufacturing processes. Economically, PestNu strengthens the EU's position and industry, particularly for small/medium enterprises, stimulating start-ups, creating employment , providing innovative solutions, and increasing digitization. Lastly, PestNu improves the resilience of food systems to shocks and stresses and raises awareness among policymakers, businesses and citizens about the potential of innovative systemic solutions and the need for their widespread adoption at the EU scale, leading to behavioral change.