Project description
Simulation-based imaging framework for assessing risk of intracranial aneurysm rupture
An unruptured intracranial aneurysm (UIA) is a relatively common cerebrovascular disorder with a considerable number of patients at high risk of aneurysm rupture, a life-threatening condition. The EU-funded Sim4DFlow project’s core objective is to develop a novel simulation-based imaging framework that integrates the advanced computational techniques of 4D flow magnetic resonance imaging (MRI), machine learning (ML) and computational fluid dynamics (CFD). Identifying the factors contributing to UIA rupture and applying 4D flow MRI, ML algorithms and CFD models will enable advanced quantification of personal rupture risk assessment in UIA patients.
Objective
Unruptured intracranial aneurysm (UIA) is a severe, relatively common cerebrovascular disorder in the general population. Although such aneurysms are mostly asymptomatic and may not burst, a considerable number of UIA patients remain on a high risk of aneurysm rupture, a serious life-threatening condition. Thus, is crucial to decide the timing and type (clipping, coils, and/or stent, flow diverter) of surgical intervention. However, the optimal management strategy of UIA is still open to clinical debate, with recommendations for elective repair after diagnosis based primarily on the aneurysm size and location.
While cardiovascular flow imaging has strong potential to provide the required information for surgical decision-making, currently, flow imaging and assessment is not sufficient to reliably predict rupture and quantitatively assess the risk of haemorrhage. By identifying factors contributing to UIA rupture and by incorporating advanced computational techniques, i.e. 4D flow magnetic resonance imaging (MRI), machine learning (ML) algorithms, and computational fluid dynamics (CFD) models, this project will technologically advance quantification of rupture risk assessment on an UIA patient-specific basis.
This project, Sim4DFlow, core technological aim is to develop a novel simulation-based imaging framework that can integrate the advanced computational techniques of 4D flow MRI, ML, and CFD. Subsequently, Sim4DFlow will test and validate the framework prognostic capacity in the laboratory setting against relevant data of UIA patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine surgery surgical procedures
- natural sciences physical sciences classical mechanics fluid mechanics fluid dynamics computational fluid dynamics
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- natural sciences computer and information sciences artificial intelligence machine learning
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.4. - SPREADING EXCELLENCE AND WIDENING PARTICIPATION
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-WF-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1678 Nicosia
Cyprus
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.