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Deciphering Gene Regulatory Networks governing Mammalian Sex Determination

Project description

Investigating the genetic routes of sex determination

In many mammalian species sex is determined genetically by the expression of one or several genes carried by sex chromosomes. There is an antagonism between male and female pathways in fate reinforcement, yet the mechanism of interplay and downstream events remain elusive. The EU-funded EnhanceSex project has developed an in vitro and in vivo system for generating mouse gonadal progenitors from embryonic stem cells and will use it to study the gene regulatory networks governing mammalian sex determination. Apart from fundamental knowledge into development, project results will provide important insight into disorders of sex development and open new possibilities for novel interventions against infertility.

Coordinator

BAR ILAN UNIVERSITY
Net EU contribution
€ 1 651 868,00
Address
Bar Ilan University Campus
52900 Ramat Gan
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00