Project description
Investigating the genetic routes of sex determination
In many mammalian species sex is determined genetically by the expression of one or several genes carried by sex chromosomes. There is an antagonism between male and female pathways in fate reinforcement, yet the mechanism of interplay and downstream events remain elusive. The EU-funded EnhanceSex project has developed an in vitro and in vivo system for generating mouse gonadal progenitors from embryonic stem cells and will use it to study the gene regulatory networks governing mammalian sex determination. Apart from fundamental knowledge into development, project results will provide important insight into disorders of sex development and open new possibilities for novel interventions against infertility.
Fields of science
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Topic(s)
Funding Scheme
HORIZON-AG - HORIZON Action Grant Budget-Based
Coordinator
52900 Ramat Gan
Israel
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