Deciphering Gene Regulatory Networks governing Mammalian Sex Determination

Project description

Investigating the genetic routes of sex determination

In many mammalian species sex is determined genetically by the expression of one or several genes carried by sex chromosomes. There is an antagonism between male and female pathways in fate reinforcement, yet the mechanism of interplay and downstream events remain elusive. The EU-funded EnhanceSex project has developed an in vitro and in vivo system for generating mouse gonadal progenitors from embryonic stem cells and will use it to study the gene regulatory networks governing mammalian sex determination. Apart from fundamental knowledge into development, project results will provide important insight into disorders of sex development and open new possibilities for novel interventions against infertility.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › genetics › genomes

Programme(s)

• HORIZON.1.1 - European Research Council (ERC) Main Programme

Topic(s)

• ERC-2021-STG - ERC STARTING GRANTS

Call for proposal

ERC-2021-STG

See other projects for this call

Funding Scheme

HORIZON-AG - HORIZON Action Grant Budget-Based

Coordinator

BAR ILAN UNIVERSITY

Net EU contribution

€ 1 651 868,00

Address

Bar Ilan University Campus
52900 Ramat Gan
Israel

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00