Deciphering Gene Regulatory Networks governing Mammalian Sex Determination

Project Information

EnhanceSex

Grant agreement ID: 101039928

DOI

10.3030/101039928

EC signature date 17 February 2022

Start date 1 April 2022

End date 31 March 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 651 868,00

EU contribution

€ 1 651 868,00

Coordinated by

BAR ILAN UNIVERSITY
Israel

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Deliverables

Documents, reports (1)

Data Management Plan

The EnhanceSex project will generate data both in the form of experimental results and metadata arising from RNA sequencing ATACSeq ChIPSeq and PCHiC including its computational analysis Experimental results will be openly available by publishing in scientific journals via the openaccess option All sequencing and experimental data will be stored and backed up in the lab servers and online cloud using Dropbox unlimited business account The sequencing data will be deposited at GEO public repository and accession numbers made available via scientific publishing in the above said openaccess publications Scripts and pipelines will be made available using open access publication and on the Gonen lab website at wwwgonenlabcom

Publications

Peer reviewed articles (5)

Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination

Author(s): Meshi Ridnik, Elisheva Abberbock, Veronica Alipov, Shelly Ziv Lhermann, Shoham Kaufman, Maor Lubman, Francis Poulat, Nitzan Gonen*
Published in: Nucleic Acids Research, 2024, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkae178

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

Author(s): Stévant I., Gonen N.*, Poulat F.*
Published in: Front Cell Dev Biol, 2024, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2023.1327410

Epigenetic Aging of Mammalian Gametes

Author(s): Klustein M.*, Gonen N.*
Published in: Molecular Reproduction and Development, 2023, ISSN 1040-452X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrd.23717

"Towards a ""testis in a dish"": generation of mouse testicular organoids that recapitulate testis structure and expression profiles"

Author(s): Stopel A., Lev C., Dahari S., Adibi O., Armon L., Gonen N.
Published in: International Journal of Biological Sciences, 2024, ISSN 1449-2288
Publisher: International Journal of Biological Sciences
DOI: 10.7150/ijbs.89480

In vitro cellular reprogramming to model gonad development and its disorders

Author(s): Gonen, Nitzan; Eozenou, Caroline; Mitter, Richard; Elzaiat, Maëva; Stévant, Isabelle; Aviram, Rona; Bernardo, Andreia Sofia; Chervova, Almira; Wankanit, Somboon; Frachon, Emmanuel; Commere, Pierre-Henri; Brailly-Tabard, Sylvie; Valon, Léo; Barrio Cano, Laura; Levayer, Romain; Mazen, Inas; Gobaa, Samy; Smith, James C.; McElreavey, Kenneth; Lovell-Badge, Robin; Bashamboo, Anu
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: Science
DOI: 10.25418/crick.21841020.v1